Role of respiratory uncoupling in drug-induced mitochondrial permeability transition

Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening

(2020) Yugo Ikeyama et al.   TOXICOLOGY IN VITRO

Development of a decision tree for mitochondrial dysfunction: Uncoupling of oxidative phosphorylation

(2018) Steven J. Enoch et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat

(2018) Masahiro Segawa et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

The mitochondrial permeability transition pore in AD 2016: An update

(2016) Lucia Biasutto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Comprehensive analysis of mitochondrial permeability transition pore activity in living cells using fluorescence-imaging-based techniques

(2016) Massimo Bonora et al.   Nature Protocols

Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes

(2016) Cong Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The iPLA2γ is identified as the membrane potential sensitive phospholipase in liver mitochondria

(2015) Adam J. Rauckhorst et al.   FEBS LETTERS

Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolic activation of hepatotoxic drug (benzbromarone) induced mitochondrial membrane permeability transition

(2015) Maho Shirakawa et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of the Ca-independent phospholipase A2in liver mitochondria by changes in the energetic state

(2014) Adam J. Rauckhorst et al.   JOURNAL OF LIPID RESEARCH

Identifying the components of the elusive mitochondrial permeability transition pore

(2014) J. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria: The gateway for tamoxifen-induced liver injury

(2014) Mariana P.C. Ribeiro et al.   TOXICOLOGY

Toxicity assessments of nonsteroidal anti-inflammatory drugs in isolated mitochondria, rat hepatocytes, and zebrafish show good concordance across chemical classes

(2013) Sashi Nadanaciva et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

(2012) Mathieu Porceddu et al.   TOXICOLOGICAL SCIENCES

The Development of Structure-Activity Relationships for Mitochondrial Dysfunction: Uncoupling of Oxidative Phosphorylation

(2012) Russell T. Naven et al.   TOXICOLOGICAL SCIENCES

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

Protective action of tamoxifen on carboxyatractyloside-induced mitochondrial permeability transition

(2011) Luz Hernández-Esquivel et al.   LIFE SCIENCES

A biophysical approach to phospholipase A2 activity and inhibition by anti-inflammatory drugs

(2010) Diana Gaspar et al.   BIOPHYSICAL CHEMISTRY

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation

(2008) María Niklison Chirou et al.   FEBS Journal

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY