Structures and target RNA preferences of the RNA-binding protein family of IGF2BPs: An overview

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

(2021) Jinyan Wang et al.   Cancer Cell International

Comprehensive landscape and future perspectives of circular RNAs in colorectal cancer

(2021) Fei Long et al.   Molecular Cancer

LncRNA CDKN2B-AS1 stabilized by IGF2BP3 drives the malignancy of renal clear cell carcinoma through epigenetically activating NUF2 transcription

(2021) Xina Xie et al.   Cell Death & Disease

Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution

(2020) Doo Nam Kim et al.   Nature Communications

IGF2BP3 From Physiology to Cancer: Novel Discoveries, Unsolved Issues, and Future Perspectives

(2020) Caterina Mancarella et al.   Frontiers in Cell and Developmental Biology

Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes

(2020) Florent Delhommel et al.   JOURNAL OF MOLECULAR BIOLOGY

How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms

(2020) Meredith Corley et al.   MOLECULAR CELL

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

(2020) Hyun-Seo Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences

(2020) Arttu Jolma et al.   GENOME RESEARCH

An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs

(2020) Takako Ohyama et al.   NUCLEIC ACIDS RESEARCH

The Diverse Functions of IMP2/IGF2BP2 in Metabolism

(2020) Ning Dai   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pseudo-RNA-Binding Domains Mediate RNA Structure Specificity in Upstream of N-Ras

(2020) Nele Merret Hollmann et al.   Cell Reports

Initiation of stress granule assembly by rapid clustering of IGF2BP proteins upon osmotic shock

(2020) Wei-jie Zeng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IGF2BP3 May Contributes to Lung Tumorigenesis by Regulating the Alternative Splicing of PKM

(2020) Huang Xueqing et al.   Frontiers in Bioengineering and Biotechnology

The SARS-CoV-2 RNA–protein interactome in infected human cells

(2020) Nora Schmidt et al.   Nature Microbiology

Methods for RNA Modification Mapping Using Deep Sequencing: Established and New Emerging Technologies

(2019) Yuri Motorin et al.   Genes

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

(2019) Nina Ripin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties

(2019) Robert Dagil et al.   NUCLEIC ACIDS RESEARCH

RNA structure maps across mammalian cellular compartments

(2019) Lei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

(2019) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Beyond CLIP: advances and opportunities to measure RBP–RNA and RNA–RNA interactions

(2019) Chenyu Lin et al.   NUCLEIC ACIDS RESEARCH

Insulin-like growth factor II mRNA-binding protein 3 promotes cell proliferation, migration and invasion in human glioblastoma

(2019) Chao Wu et al.   OncoTargets and Therapy

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation

(2019) Laura Regué et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3

(2019) Tim Schneider et al.   Nature Communications

Long non‐coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution

(2019) Yupeng Zhang et al.   EMBO REPORTS

RNA-centric approaches to study RNA-protein interactions in vitro and in silico

(2019) Alessandro Dasti et al.   METHODS

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An RNA-centric dissection of host complexes controlling flavivirus infection

(2019) Yaw Shin Ooi et al.   Nature Microbiology

The structural basis for RNA selectivity by the IMP family of RNA-binding proteins

(2019) Jeetayu Biswas et al.   Nature Communications

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

Single mRNP Analysis Reveals that Small Cytoplasmic mRNP Granules Represent mRNA Singletons

(2019) Àngels Mateu-Regué et al.   Cell Reports

IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader

(2019) Xiaoge Hu et al.   CELL DEATH AND DIFFERENTIATION

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

(2018) Xinwei Huang et al.   Journal of Hematology & Oncology

Sequence, Structure, and Context Preferences of Human RNA Binding Proteins

(2018) Daniel Dominguez et al.   MOLECULAR CELL

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

Analyses of mRNA structure dynamics identify embryonic gene regulatory programs

(2018) Jean-Denis Beaudoin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

Analyses of mRNA structure dynamics identify embryonic gene regulatory programs

(2018) Jean-Denis Beaudoin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy

(2018) Feifei Liu et al.   Acta Pharmaceutica Sinica B

Structural basis of IMP3 RRM12 recognition of RNA

(2018) Min Jia et al.   RNA

Epitranscriptomic Code and Its Alterations in Human Disease

(2018) Rajashekar Varma Kadumuri et al.   TRENDS IN MOLECULAR MEDICINE

Fluorescence Imaging Methods to Investigate Translation in Single Cells

(2018) Jeetayu Biswas et al.   Cold Spring Harbor Perspectives in Biology

RNA m6A modification and its function in diseases

(2018) Jiyu Tong et al.   Frontiers of Medicine

IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner

(2018) Simon Müller et al.   NUCLEIC ACIDS RESEARCH

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

(2018) Marta Pabis et al.   NUCLEIC ACIDS RESEARCH

Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition

(2017) Andreas Schlundt et al.   METHODS

20 years of the SMART protein domain annotation resource

(2017) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability

(2017) Wei Zhao et al.   Oncotarget

Mechanism of β-actin mRNA Recognition by ZBP1

(2017) Giuseppe Nicastro et al.   Cell Reports

Advances and challenges in the detection of transcriptome-wide protein-RNA interactions

(2017) Emily C. Wheeler et al.   Wiley Interdisciplinary Reviews-RNA

Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7

(2017) Irene Beusch et al.   eLife

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

(2016) Nils Degrauwe et al.   GENES & DEVELOPMENT

RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation

(2016) Jayanth Kumar Palanichamy et al.   JOURNAL OF CLINICAL INVESTIGATION

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family

(2016) Bianca Busch et al.   NUCLEIC ACIDS RESEARCH

The expanding universe of ribonucleoproteins: of novel RNA-binding proteins and unconventional interactions

(2016) Benedikt M. Beckmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

(2016) Anant A. Agrawal et al.   Nature Communications

IGF2BP3 Modulates the Interaction of Invasion-Associated Transcripts with RISC

(2016) Hanane Ennajdaoui et al.   Cell Reports

Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival

(2016) Anne E. Conway et al.   Cell Reports

CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs

(2016) Tim Schneider et al.   Scientific Reports

KH–RNA interactions: back in the groove

(2015) Giuseppe Nicastro et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network

(2015) P. A. Cassar et al.   EMBO REPORTS

Specificity and nonspecificity in RNA–protein interactions

(2015) Eckhard Jankowsky et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein–RNA specificity by high-throughput principal component analysis of NMR spectra

(2015) Katherine M. Collins et al.   NUCLEIC ACIDS RESEARCH

Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA

(2015) R Mizutani et al.   ONCOGENE

Structural basis for the activation of theC. elegansnoncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3

(2015) Katharina Nakel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS

(2015) Marianna Teplova et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Drosophila Imp iCLIP identifies an RNA assemblage coordinating F-actin formation

(2015) Heidi Theil Hansen et al.   GENOME BIOLOGY

Breaking the protein-RNA recognition code

(2014) Janosch Hennig et al.   CELL CYCLE

Interaction between Ribosome Assembly Factors Krr1 and Faf1 Is Essential for Formation of Small Ribosomal Subunit in Yeast

(2014) Sanduo Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1

(2014) Iren Wang et al.   NUCLEIC ACIDS RESEARCH

The dynamic duo: Combining NMR and small angle scattering in structural biology

(2014) Janosch Hennig et al.   PROTEIN SCIENCE

The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer

(2014) Marcell Lederer et al.   SEMINARS IN CANCER BIOLOGY

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

(2014) Lars Jønson et al.   Cell Reports

KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells

(2014) Keisuke Taniuchi et al.   NEOPLASIA

The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

(2013) Hong Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains

(2013) Kristin Wächter et al.   BIOLOGICAL CHEMISTRY

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

(2013) N. Dai et al.   GENES & DEVELOPMENT

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)

(2013) Monika Hämmerle et al.   HEPATOLOGY

A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3′ untranslated region AU-rich regulatory element

(2013) Soonmoon Yoo et al.   JOURNAL OF NEUROCHEMISTRY

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Prediction of clustered RNA-binding protein motif sites in the mammalian genome

(2013) Chaolin Zhang et al.   NUCLEIC ACIDS RESEARCH

Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization

(2013) T Rivera Vargas et al.   ONCOGENE

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

(2012) Jessica L. Bell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Spatial arrangement of an RNA zipcode identifies mRNAs under post-transcriptional control

(2012) V. L. Patel et al.   GENES & DEVELOPMENT

Modular recognition of nucleic acids by PUF, TALE and PPR proteins

(2012) Aleksandra Filipovska et al.   Molecular BioSystems

Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65

(2012) Mahavir Singh et al.   MOLECULAR CELL

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

KH domains with impaired nucleic acid binding as a tool for functional analysis

(2012) David Hollingworth et al.   NUCLEIC ACIDS RESEARCH

Automated 3D structure composition for large RNAs

(2012) Mariusz Popenda et al.   NUCLEIC ACIDS RESEARCH

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Insulin-like growth factor II-messenger RNA-binding protein-3 and lung cancer

(2011) JJ Findeis-Hosey et al.   BIOTECHNIC & HISTOCHEMISTRY

Modular protein-RNA interactions regulating mRNA metabolism: a role for NMR

(2011) Cyprian D. Cukier et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

(2011) Cameron D. Mackereth et al.   NATURE

Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP

(2011) Marianna Teplova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple conformations of SAM-II riboswitch detected with SAXS and NMR spectroscopy

(2011) Bin Chen et al.   NUCLEIC ACIDS RESEARCH

Protein-RNA and Protein-Protein Recognition by Dual KH1/2 Domains of the Neuronal Splicing Factor Nova-1

(2011) Marianna Teplova et al.   STRUCTURE

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

ZBP1 recognition of  -actin zipcode induces RNA looping

(2010) J. A. Chao et al.   GENES & DEVELOPMENT

Novel Protein–Protein Contacts Facilitate mRNA 3′-Processing Signal Recognition by Rna15 and Hrp1

(2010) Thomas C. Leeper et al.   JOURNAL OF MOLECULAR BIOLOGY

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

(2010) Irene Díaz-Moreno et al.   NUCLEIC ACIDS RESEARCH

Improving small-angle X-ray scattering data for structural analyses of the RNA world

(2010) R. P. Rambo et al.   RNA

IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes

(2009) Jan Christiansen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Vg1RBP phosphorylation by Erk2 MAP kinase correlates with the cortical release of Vg1 mRNA during meiotic maturation of Xenopus oocytes

(2009) A. Git et al.   RNA

RNA recognition motifs: boring? Not quite

(2008) Antoine Cléry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and function of KH domains

(2008) Roberto Valverde et al.   FEBS Journal

Structure of a Construct of a Human Poly(C)-binding Protein Containing the First and Second KH Domains Reveals Insights into Its Regulatory Mechanisms

(2008) Zhihua Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-Like Growth Factor II mRNA Binding Protein 1 Associates with Gag Protein of Human Immunodeficiency Virus Type 1, and Its Overexpression Affects Virus Assembly

(2008) Y. Zhou et al.   JOURNAL OF VIROLOGY

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

(2008) A. Dereeper et al.   NUCLEIC ACIDS RESEARCH

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

(2008) D. Weidensdorfer et al.   RNA