Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Xiaojing Qiao, Xiuju Wu, Yan Zhao, Yang Yang, Li Zhang, Xinjiang Cai, Jocelyn A. A. Ma, Jaden Ji, Karen Lyons, Kristina I. I. Bostrom, Yucheng Yao
Summary: Glucocorticoids can convert osteoblast-lineage cells into endothelial-like cells, leading to bone loss. This is due to the direct targeting of Foxc2 and Osterix by the glucocorticoid receptor, which drives the transition of osteoblast-lineage cells to endothelial-like cells.
Article
Biochemistry & Molecular Biology
Zhao-hua Deng, Jing Zhong, Hai-lin Jiang, Hyun-Woo Jeong, Jian-wei Chen, Ya-hai Shu, Ming Tan, Ralf H. Adams, Ke-ping Xie, Qi Chen, Yang Liu
Summary: Antipsychotic agent haloperidol induces vascular defects in bone marrow, affecting hematopoiesis and hematopoietic stem/progenitor cells. This effect is reversible after withdrawal of haloperidol. Mechanistically, haloperidol blocks the secretion of VEGF-A from HSPCs.
Review
Pharmacology & Pharmacy
Cornelia Lee-Thedieck, Peter Schertl, Gerd Klein
Summary: This review provides a comprehensive overview of the extracellular matrix (ECM) in hematopoietic stem cell (HSC) niches and highlights its importance in regulating cellular function and niche structure. The role of different classes of ECM molecules and their interactions with cells are discussed, along with the significance of matrix remodeling and biophysics in HSC niche function. The review also examines the application of current knowledge of ECM in artificial HSC niches for HSC expansion, targeted differentiation, and drug testing.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Engineering, Biomedical
Chandralekha Chatterjee, Peter Schertl, Miriam Frommer, Anita Ludwig-Husemann, Anna Mohra, Nadine Dilger, Toufik Naolou, Sophia Meermeyer, Timna Claire Bergmann, Alejandro Alonso Calleja, Cornelia Lee-Thedieck
Summary: Artificial niches play a crucial role in regenerative medicine research, providing insights into the biophysical and biochemical processes of hematopoietic stem cells, as well as facilitating HSCs expansion and targeted differentiation. Due to the lack of natural microenvironment, biomaterials are essential in recreating niche environments, offering promising applications in various fields.
ACTA BIOMATERIALIA
(2021)
Article
Multidisciplinary Sciences
Claire H. Masterson, Arata Tabuchi, Grace Hogan, Glenn Fitzpatrick, Steven W. Kerrigan, Mirjana Jerkic, Wolfgang M. Kuebler, John G. Laffey, Gerard F. Curley
Summary: Mesenchymal stem/stromal cells (MSCs) may be physically obstructed in the pulmonary vasculature and do not exhibit rolling/adhesion properties, while receptor interaction may be necessary for their retention in the infected lung.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Sarah Bouali, Roxann Hetu-Arbour, Celia Gardet, Krista M. Heinonen
Summary: Vangl2 is a crucial regulator in the self-renewal and differentiation of HSCs. Deletion of Vangl2 impairs HSC expansion and hematopoietic recovery, indicating its essential role in hematopoiesis regulation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Roxann Hetu-Arbour, Mouna Tlili, Fabio Luiz Bandeira Ferreira, Belma Melda Abidin, Edward O. Kwarteng, Krista M. Heinonen
Summary: This study reveals a new autocrine role of Wnt4 in hematopoietic stem cell self-renewal, indicating that the regulation of Wnt signaling in hematopoiesis may not require Wnt secretion and could be independent of morphogen gradients.
Review
Nutrition & Dietetics
Siyuan Sun, Yingxue Han, Yumei Lei, Yifei Yu, Yanbin Dong, Juan Chen
Summary: This review comprehensively summarizes the intrinsic factors involved in the regulation of hematopoietic stem cells (HSCs), including RNA-binding protein, modulators in epigenetics, and enhancer-promotor-mediated transcription. It also explores their roles in bone marrow transplantation therapies and autoimmune diseases. Additionally, it discusses the effects of high-fat diets and nutrients (such as vitamins, amino acids, probiotics, and prebiotics) on HSC regulation, providing valuable insights for future HSC research.
Review
Endocrinology & Metabolism
Francesca Miglietta, Luca Iamartino, Gaia Palmini, Francesca Giusti, Francesca Marini, Teresa Iantomasi, Maria Luisa Brandi
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective therapy for various hematopoietic diseases. While the mortality rate has decreased, late HSCT-related complications have emerged, particularly affecting the endocrine system and mineral metabolism. This review focuses on the impact of HSCT on calcium homeostasis, including osteoporosis and renal dysfunctions, and discusses possible secondary implications on parathyroid glands and calcium homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Xiaojing Qiao, Yang Yang, Yan Zhao, Xiuju Wu, Li Zhang, Xinjiang Cai, Jaden Ji, Kristina I. Bostrom, Yucheng Yao
Summary: This study identifies the inhibition of aurora kinase A as a potential approach to counteract unwanted transitions of osteoblast lineage cells and prevent glucocorticoid-induced bone loss. The interaction between aurora A and the glucocorticoid receptor is essential for the modulation of key factors in this process. These findings may offer a novel strategy for ameliorating the adverse effects of glucocorticoid treatment on bone health.
Review
Immunology
Yan Man, Zhixiang Lu, Xiangmei Yao, Yuemin Gong, Tonghua Yang, Yajie Wang
Summary: PGF is a life-threatening complication that occurs after transplantation and predicting and preventing it remains challenging. This study finds that CD34(+) cells, bone marrow microenvironment, and factors like viral infection and iron overload are closely related to the occurrence of PGF. The article summarizes the common risk factors and potential mechanism of PGF, as well as discusses the safety and efficacy of new strategies for treating it.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida, Toshio Suda
Summary: By studying the mitochondrial metabolism and ATP citrate lyase (ACLY) in hematopoietic stem cells (HSCs), we have gained new insights into the regulation of HSCs during hematopoietic regeneration.
Article
Biophysics
Zimo Zhou, Da Liu
Summary: Porous tantalum-based biomaterials have been widely used in bone defect repair due to their unique properties and excellent biocompatibility. BMSCs, as an important type of stem cells, have shown great potential in regulating the effects of porous tantalum. This study reviews the characteristics of porous tantalum-based biomaterials and the regulatory mechanisms on BMSCs, and discusses the feasibility of seeding BMSCs in porous tantalum-based biomaterials for tissue repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
