scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function
出版年份 2021 全文链接
标题
scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T
reg
function
作者
关键词
-
出版物
Science Translational Medicine
Volume 13, Issue 610, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2021-09-09
DOI
10.1126/scitranslmed.abd8995
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Vitiligo: Mechanisms of Pathogenesis and Treatment
- (2020) Michael L. Frisoli et al. Annual Review of Immunology
- Altered expression of nuclear factor of activated T cells, forkhead box P3, and immune‐suppressive genes in regulatory T cells of generalized vitiligo patients
- (2020) Prashant S. Giri et al. Pigment Cell & Melanoma Research
- Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis
- (2020) Thomas B. Rojahn et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells
- (2020) Cristina Ferreira et al. NATURE IMMUNOLOGY
- Decreased suppression of CD8 + and CD4 + T cells by peripheral regulatory T cells in generalized vitiligo due to reduced NFATC1 and FOXP3 proteins
- (2020) Prashant S. Giri et al. EXPERIMENTAL DERMATOLOGY
- Integrated transcriptomic and proteomic analysis of human eccrine sweat glands identifies missing and novel proteins
- (2019) Chan Hyun Na et al. MOLECULAR & CELLULAR PROTEOMICS
- Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations
- (2018) Christina Philippeos et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
- (2018) Jihwan Park et al. SCIENCE
- Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo
- (2018) Jillian M. Richmond et al. Science Translational Medicine
- Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution
- (2018) Jeffrey B. Cheng et al. Cell Reports
- Vitiligo: Mechanistic insights lead to novel treatments
- (2017) Michael L. Frisoli et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of Disease
- (2017) Jillian M. Richmond et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Current and emerging treatments for vitiligo
- (2017) Michelle Rodrigues et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity
- (2017) James P. Strassner et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- CCR8+FOXp3+Tregcells as master drivers of immune regulation
- (2017) Yiftah Barsheshet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo
- (2016) X. X. Wang et al. BRITISH JOURNAL OF DERMATOLOGY
- Single-cell barcoding and sequencing using droplet microfluidics
- (2016) Rapolas Zilionis et al. Nature Protocols
- Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
- (2016) Nicholas Collins et al. Nature Communications
- Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
- (2016) Simon Joost et al. Cell Systems
- Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation
- (2015) M.K. Tembhre et al. BRITISH JOURNAL OF DERMATOLOGY
- Cellular stress and innate inflammation in organ-specific autoimmunity: lessons learned from vitiligo
- (2015) John E. Harris IMMUNOLOGICAL REVIEWS
- Confetti-like depigmentation: A potential sign of rapidly progressing vitiligo
- (2015) Juan Jesús Sosa et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- A draft network of ligand–receptor-mediated multicellular signalling in human
- (2015) Jordan A. Ramilowski et al. Nature Communications
- Assessment of tissue FoxP3+, CD4+and CD8+T-cells in active and stable nonsegmental vitiligo
- (2014) Marwa Abdallah et al. INTERNATIONAL JOURNAL OF DERMATOLOGY
- Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals
- (2014) Yuka Maeda et al. SCIENCE
- CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo
- (2014) M. Rashighi et al. Science Translational Medicine
- Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses
- (2013) Sarah Terras et al. INTERNATIONAL JOURNAL OF DERMATOLOGY
- A Quantitative Increase in Regulatory T Cells Controls Development of Vitiligo
- (2013) Shilpak Chatterjee et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Decreased regulatory T-cells and CD4+/CD8+ratio correlate with disease onset and progression in patients with generalized vitiligo
- (2013) Mitesh Dwivedi et al. Pigment Cell & Melanoma Research
- Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo
- (2013) J. A. Mosenson et al. Science Translational Medicine
- An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation
- (2012) Tarmo Äijö et al. BMC GENOMICS
- Tumor-Derived Chemokine CCL5 Enhances TGF- -Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells
- (2012) L.-Y. Chang et al. CANCER RESEARCH
- IFN- Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease
- (2012) C. Koenecke et al. JOURNAL OF IMMUNOLOGY
- A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-γ for Autoreactive CD8+ T-Cell Accumulation in the Skin
- (2012) John E. Harris et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
- (2012) Guangchuang Yu et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Global Activation of CD8+ Cytotoxic T Lymphocytes Correlates with an Impairment in Regulatory T Cells in Patients with Generalized Vitiligo
- (2012) Yang Lili et al. PLoS One
- Differentiation and function of Foxp3+ effector regulatory T cells
- (2012) Erika Cretney et al. TRENDS IN IMMUNOLOGY
- Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis
- (2011) Ting Feng et al. GASTROENTEROLOGY
- Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes
- (2011) Stephanie A. McClymont et al. JOURNAL OF IMMUNOLOGY
- Functional defects of peripheral regulatory T lymphocytes in patients with progressive vitiligo
- (2011) M. Ben Ahmed et al. Pigment Cell & Melanoma Research
- CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells
- (2010) Marcin Dobaczewski et al. AMERICAN JOURNAL OF PATHOLOGY
- Differentiation of Effector CD4 T Cell Populations
- (2010) Jinfang Zhu et al. Annual Review of Immunology
- Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance
- (2010) Emi K. Nishimura et al. Cell Stem Cell
- Interleukin-26: An IL-10-related cytokine produced by Th17 cells
- (2010) Raymond P. Donnelly et al. CYTOKINE & GROWTH FACTOR REVIEWS
- CD8 T Cells Activated in Distinct Lymphoid Organs Differentially Express Adhesion Proteins and Coexpress Multiple Chemokine Receptors
- (2010) A. R. Ferguson et al. JOURNAL OF IMMUNOLOGY
- Mechanisms of Spatial and Temporal Development of Autoimmune Vitiligo in Tyrosinase-Specific TCR Transgenic Mice
- (2010) Randal K. Gregg et al. JOURNAL OF IMMUNOLOGY
- Reduced skin homing by functional Treg in vitiligo
- (2010) Jared Klarquist et al. Pigment Cell & Melanoma Research
- A scaling normalization method for differential expression analysis of RNA-seq data
- (2010) Mark D Robinson et al. GENOME BIOLOGY
- Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients
- (2009) Jasper G. van den Boorn et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
- (2009) Meghan A Koch et al. NATURE IMMUNOLOGY
- Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
- (2009) Markus Feuerer et al. NATURE IMMUNOLOGY
- Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells
- (2008) C. Figueiredo et al. BLOOD
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