Ebola vaccine–induced protection in nonhuman primates correlates with antibody specificity and Fc-mediated effects

IgA subclasses have different effector functions associated with distinct glycosylation profiles

(2020) Ulrike Steffen et al.   Nature Communications

There Is (Scientific) Strength in Numbers: A Comprehensive Quantitation of Fc Gamma Receptor Numbers on Human and Murine Peripheral Blood Leukocytes

(2020) Christina Kerntke et al.   Frontiers in Immunology

Immunologic timeline of Ebola virus disease and recovery in humans

(2020) Anita K. McElroy et al.   JCI Insight

Safety and immunogenicity of a two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): a randomised, observer-blind, participant-blind, placebo-controlled, phase 2 trial

(2020) Andrew J Pollard et al.   LANCET INFECTIOUS DISEASES

Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

(2019) Liam B. King et al.   Nature Communications

Differential requirements for FcγR engagement by protective antibodies against Ebola virus

(2019) Stylianos Bournazos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV

(2019) Stefanie A. Ehrhardt et al.   NATURE MEDICINE

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

(2018) Pavlo Gilchuk et al.   IMMUNITY

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

(2018) Kelly L Warfield et al.   JOURNAL OF INFECTIOUS DISEASES

Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2–MPER region

(2018) Andrew I. Flyak et al.   Nature Microbiology

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

(2018) Erica Ollmann Saphire et al.   CELL

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

(2018) Bronwyn M. Gunn et al.   Cell Host & Microbe

Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIV

(2018) Margaret E. Ackerman et al.   NATURE MEDICINE

Can Ebola Virus Vaccines Have Universal Immune Correlates of protection?

(2018) Michelle Meyer et al.   TRENDS IN MICROBIOLOGY

Qualitative Profiling of the Humoral Immune Response Elicited by rVSV-ΔG-EBOV-GP Using a Systems Serology Assay, Domain Programmable Arrays

(2018) Mariano Sanchez-Lockhart et al.   Cell Reports

Antibody Repertoires to the Same Ebola Vaccine Antigen Are Differentially Affected by Vaccine Vectors

(2018) Michelle Meyer et al.   Cell Reports

Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap

(2018) Philipp A. Ilinykh et al.   PLoS Pathogens

Antibody-mediated protection against Ebola virus

(2018) Erica Ollmann Saphire et al.   NATURE IMMUNOLOGY

Immune Responses to Novel Adenovirus Type 26 and Modified Vaccinia Virus Ankara–Vectored Ebola Vaccines at 1 Year

(2017) Rebecca L. Winslow et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!)

(2017) Ana Maria Henao-Restrepo et al.   LANCET

Chimpanzee Adenovirus Vector Ebola Vaccine

(2017) Julie E. Ledgerwood et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV

(2017) Anne Rechtien et al.   Cell Reports

Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice

(2017) Daniel A. J. Mitchell et al.   Human Vaccines & Immunotherapeutics

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

(2016) Andrew I. Flyak et al.   CELL

Safety and Immunogenicity of Novel Adenovirus Type 26– and Modified Vaccinia Ankara–Vectored Ebola Vaccines

(2016) Iain D. Milligan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16 + Monocytes

(2016) Anja Lüdtke et al.   JOURNAL OF INFECTIOUS DISEASES

A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA

(2016) Katie Ewer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Passively Acquired Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity in HIV-Infected Infants Is Associated with Reduced Mortality

(2015) Caitlin Milligan et al.   Cell Host & Microbe

Aerosolized Ebola vaccine protects primates and elicits lung-resident T cell responses

(2015) Michelle Meyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

(2015) Ana Maria Henao-Restrepo et al.   LANCET

Clinical presentation, biochemical, and haematological parameters and their association with outcome in patients with Ebola virus disease: an observational cohort study

(2015) Luke Hunt et al.   LANCET INFECTIOUS DISEASES

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys

(2015) D. H. Barouch et al.   SCIENCE

Identification of Continuous Human B-Cell Epitopes in the VP35, VP40, Nucleoprotein and Glycoprotein of Ebola Virus

(2014) Pierre Becquart et al.   PLoS One

Massive Parallelization of Serial Inference Algorithms for a Complex Generalized Linear Model

(2013) Marc A. Suchard et al.   ACM Transactions on Modeling and Computer Simulation

Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

(2013) Dan H. Barouch et al.   CELL

Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates

(2013) A. Marzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody Quality and Protection from Lethal Ebola Virus Challenge in Nonhuman Primates Immunized with Rabies Virus Based Bivalent Vaccine

(2013) Joseph E. Blaney et al.   PLoS Pathogens

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

(2012) G. G. Olinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Parameters Correlate with Protection Against Ebola Virus Infection in Rodents and Nonhuman Primates

(2012) G. Wong et al.   Science Translational Medicine

HIV-Specific Antibodies Capable of ADCC Are Common in Breastmilk and Are Associated with Reduced Risk of Transmission in Women with High Viral Loads

(2012) Jennifer Mabuka et al.   PLoS Pathogens

Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus

(2011) D. Olal et al.   JOURNAL OF VIROLOGY

CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

(2011) Nancy J Sullivan et al.   NATURE MEDICINE

A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples

(2010) Margaret E. Ackerman et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Respiratory tract immunization of non-human primates with a Newcastle disease virus-vectored vaccine candidate against Ebola virus elicits a neutralizing antibody response

(2010) Joshua M. DiNapoli et al.   VACCINE

Mucosal parainfluenza virus-vectored vaccine against Ebola virus replicates in the respiratory tract of vector-immune monkeys and is immunogenic

(2010) Alexander A. Bukreyev et al.   VIROLOGY

Ebolavirusglycoprotein structure and mechanism of entry

(2009) Jeffrey E Lee et al.   Future Virology

Correlates of protective immunity for Ebola vaccines: implications for regulatory approval by the animal rule

(2009) Nancy J. Sullivan et al.   NATURE REVIEWS MICROBIOLOGY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE