Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap

Influenza virus exploits tunneling nanotubes for cell-to-cell spread

(2017) Amrita Kumar et al.   Scientific Reports

Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection

(2016) Andrew I. Flyak et al.   CELL

Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection

(2016) Carole J. Henry Dunand et al.   Cell Host & Microbe

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Chimeric Filoviruses for Identification and Characterization of Monoclonal Antibodies

(2016) Philipp A. Ilinykh et al.   JOURNAL OF VIROLOGY

Mapping of Ebolavirus Neutralization by Monoclonal Antibodies in the ZMapp Cocktail Using Cryo-Electron Tomography and Studies of Cellular Entry

(2016) Erin E. H. Tran et al.   JOURNAL OF VIROLOGY

The evolution of Ebola virus: Insights from the 2013–2016 epidemic

(2016) Edward C. Holmes et al.   NATURE

A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

(2016) Paul E. Leon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

(2016) Wenqian He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

(2016) D. Corti et al.   SCIENCE

Structural and molecular basis for Ebola virus neutralization by protective human antibodies

(2016) J. Misasi et al.   SCIENCE

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak

(2016) Z. A. Bornholdt et al.   SCIENCE

Two-mAb cocktail protects macaques against the Makona variant of Ebola virus

(2016) Xiangguo Qiu et al.   Science Translational Medicine

Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

(2016) Erica Ollmann Saphire et al.   TRENDS IN MICROBIOLOGY

Cell–cell contact promotes Ebola virus GP-mediated infection

(2016) Chunhui Miao et al.   VIROLOGY

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

(2016) Zachary A. Bornholdt et al.   mBio

Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway

(2016) Jennifer S. Spence et al.   mBio

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner

(2016) Caitlin E. Mullarkey et al.   mBio

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

(2016) Katie A. Howell et al.   Cell Reports

Antibody therapeutics for Ebola virus disease

(2016) Larry Zeitlin et al.   Current Opinion in Virology

Discovery of an antibody for pan-ebolavirus therapy

(2016) Wakako Furuyama et al.   Scientific Reports

Fc receptors and their influence on efficacy of therapeutic antibodies for treatment of viral diseases

(2015) Kuan Rong Chan et al.   Expert Review of Anti-Infective Therapy

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

Pan-ebolavirus and Pan-filovirus Mouse Monoclonal Antibodies: Protection against Ebola and Sudan Viruses

(2015) Frederick W. Holtsberg et al.   JOURNAL OF VIROLOGY

Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

(2015) G. Fibriansah et al.   SCIENCE

Ebola Virus Entry: A Curious and Complex Series of Events

(2015) Sven Moller-Tank et al.   PLoS Pathogens

Influenza A Virus Uses Intercellular Connections To Spread to Neighboring Cells

(2014) Kari L. Roberts et al.   JOURNAL OF VIROLOGY

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

(2014) Xiangguo Qiu et al.   NATURE

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Structures of protective antibodies reveal sites of vulnerability on Ebola virus

(2014) Charles D. Murin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission

(2014) Luis M. Agosto et al.   PLoS Pathogens

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission

(2013) Marine Malbec et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vesicular Stomatitis Virus-Based Vaccines Protect Nonhuman Primates against Bundibugyo ebolavirus

(2013) Chad E. Mire et al.   PLoS Neglected Tropical Diseases

Therapeutic Efficacy of Antibodies Lacking FcγR against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies

(2013) Katherine L. Williams et al.   PLoS Pathogens

Crosstalk between Human IgG Isotypes and Murine Effector Cells

(2012) M. B. Overdijk et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Marburg Virus Budding by Nonneutralizing Antibodies to the Envelope Glycoprotein

(2012) M. Kajihara et al.   JOURNAL OF VIROLOGY

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

(2012) P. Mark Hogarth et al.   NATURE REVIEWS DRUG DISCOVERY

Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease

(2012) J. M. Dye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filovirus entry into cells – new insights

(2012) Emily Happy Miller et al.   Current Opinion in Virology

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

(2011) Jan E. Carette et al.   NATURE

An Antibody against a Novel and Conserved Epitope in the Hemagglutinin 1 Subunit Neutralizes Numerous H5N1 Influenza Viruses

(2010) H.-L. J. Oh et al.   JOURNAL OF VIROLOGY

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it

(2009) Jeffrey E Lee et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Primed Ebolavirus Glycoprotein (19-Kilodalton GP1,2): Sequence and Residues Critical for Host Cell Binding

(2009) D. Dube et al.   JOURNAL OF VIROLOGY

Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

(2008) Jeffrey E. Lee et al.   NATURE

Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

(2008) Jonathan S. Towner et al.   PLoS Pathogens