Article
Environmental Sciences
Lin Fu, Hui Zhao, Ying Xiang, Hui-Xian Xiang, Biao Hu, Zhu-Xia Tan, Xue Lu, Lan Gao, Bo Wang, Hua Wang, Cheng Zhang, De-Xiang Xu
Summary: Chronic exposure to 1-nitropyrene (1-NP) induces pulmonary fibrosis in mice, potentially through oxidative stress-induced endoplasmic reticulum stress leading to epithelial-mesenchymal transition.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Physical
Guangshan Xie, Lin Zhu, Yanhao Zhang, Yuanyuan Song, Hongna Zhang, Zhu Yang, Zongwei Cai
Summary: 1-Nitropyrene (1-NP) is a potential carcinogen found in diesel exhaust-derived fine particulate matter (PM2.5) with higher cytotoxicity compared to its analogs. In human lung epithelial cell lines, 1-NP induces acute reactive oxygen species (ROS) generation and cell death. Through redox proteomics analysis, it was discovered that 1-NP remodels the redox proteome and targets the ROS reduction pathway, specifically inhibiting SOD1 activity by acting on Cys111 residue. The position of nitroxide determines the direct target of 1-NP, proposing a novel mechanism for its cytotoxicity and ROS induction.
Article
Environmental Sciences
Yuxiang Liang, Qizhi Shuai, Ying Wang, Shanshan Jin, Zihan Feng, Binghong Chen, Ting Liang, Zhizhen Liu, Hong Zhao, Zhaoyang Chen, Chunfang Wang, Jun Xie
Summary: The study reveals that 1-NP has adverse effects on embryo implantation in mice and endometrial receptivity in humans, possibly achieved through inhibition of signaling pathways, receptor expression, and cell proliferation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Chong-Sun Khoi, Yu-Wen Lin, Jia-Huang Chen, Biing-Hui Liu, Tzu-Yu Lin, Kuan-Yu Hung, Chih-Kang Chiang
Summary: This study demonstrates that OTA induces nephrotoxicity through ER stress-related apoptosis in human renal cells, with a pathway mediated by ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ruben Moreira, Ana D. Martins, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira
Summary: Low testosterone levels are a major cause of male infertility, and endocrine-disrupting chemicals such as chromium (Cr) can affect testicular steroidogenesis and male fertility. In particular, Cr(III) picolinate (CrPic(3)) has been found to inhibit enzymes involved in steroidogenesis and impact reactive oxygen species (ROS) levels, testosterone levels, and sperm motility and count. However, further research is needed to fully understand the effects of CrPic(3) on male fertility and ensure its safety for use by men.
Article
Microbiology
Sang-Hun Son, Junghwan Lee, Soo-Na Cho, Ji-Ae Choi, Jaewhan Kim, Tam Doan Nguyen, Seong-Ahn Lee, Doyi Son, Chang-Hwa Song
Summary: Novel treatment strategies for tuberculosis (TB), such as host-directed therapeutics, may offer therapeutic options for patients with drug-resistant TB. This study revealed the role of Herp in mediating crosstalk between ER stress and ROS-mediated autophagy during H37Ra infection, suggesting its potential as a therapeutic target for Mycobacterium tuberculosis (Mtb) infection.
Article
Biochemistry & Molecular Biology
Dong-Gyun Hong, Ga Yeon Song, Cheol Bin Eom, Jae-Hee Ahn, Sun Myoung Kim, Aeri Shim, Yong-Hyun Han, Yoon-Seok Roh, Chang Yeob Han, Eun Ju Bae, Hyun-Jeong Ko, Yoon Mee Yang
Summary: This study reveals the increased expression of ERdj5 in alcoholic liver disease patients and mice. Mice lacking Dnajc10 are more susceptible to alcohol-induced liver injury and hepatic steatosis. Additionally, Dnajc10 depletion worsens oxidative stress and decreases Nrf2 pathway and glutathione contents, providing protection against liver damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Food Science & Technology
Feng-Xin Qiao, Ming-Xin Sun, Zhi-Ran Xu, Yue-Cen Liu, Yan-Zhu Chen, Hai-Long Wang, Zhong-Quan Qi, Chang-Long Xu, Yu Liu
Summary: This study found that exposure to chloroacetonitrile (CAN) significantly impairs the maturation of mouse oocytes, alters the expression of multiple oocyte genes, induces reactive oxygen species production, ER stress and affects spindle assembly. In vivo experiments also showed impaired follicular development. These findings suggest that CAN exposure has adverse effects on mouse oocytes.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Kye Won Park, Dong Kwon Yang
Summary: Oxidative stress plays a significant role in the pathogenesis of heart diseases, and butein exhibits potential antioxidant effects in cardiomyocytes, providing protection against oxidative damage and suggesting its therapeutic potential for cardiac diseases.
Article
Environmental Sciences
Xiu-liang Li, Yu-lin Liu, Jia-yu Liu, Yan-yan Zhu, Xin-xin Zhu, Wei-wei Zhang, Jian Li, Ye Zhao, Ling-li Zhao, Cheng Zhang, Hua Wang, De-xiang Xu, Lan Gao
Summary: Our previous study revealed that exposure to 1-Nitropyrene (1-NP) disrupted testicular testosterone synthesis in mice, and in this present research, we found that the ER stress inhibitor 4-phenylbutyric acid (4-PBA) and the PERK kinase inhibitor GSK2606414 were able to recover the ER stress and testosterone synthases reduction caused by 1-NP in TM3 cells. Additionally, the use of the antioxidant N-Acetyl-L-cysteine (NAC) mitigated oxidative stress and attenuated ER stress, especially the PERK-eIF2a signaling activation and downregulation of testosterone synthases in 1-NP-treated TM3 cells. NAC also showed in vitro and in vivo potential for mitigating 1-NP-induced testosterone synthesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Keke Hu, Emily Relton, Nicolas Locker, Nhu T. N. Phan, Andrew G. Ewing
Summary: SGs encapsulate ROS, predominantly H2O2, and may act as communicators of cellular stress, regulating cellular metabolism and stress responses to provide cytoprotection in pathological conditions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Shijun Li, Yun Wang, Cheng Zou, Qiqi Zhu, Yiyan Wang, Haiqiong Chen, Wenjing Yang, Yuhan Tu, Haoni Yan, Xiaoheng Li, Ren-Shan Ge
Summary: This study investigated the effects of cypermethrin exposure on the development and function of Leydig cells in male rats during late puberty. The results showed that cypermethrin reduced testosterone levels and increased luteinizing hormone levels, while decreasing the number of Leydig cells. Furthermore, cypermethrin induced oxidative stress and mitochondrial damage.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Juan-Hua Quan, Fei Fei Gao, Jia-Qi Chu, Guang-Ho Cha, Jae-Min Yuk, Weiyun Wu, Young-Ha Lee
Summary: Silver nanoparticles (AgNPs) demonstrate anticancer effects against colorectal cancer through inducing mitochondrial reactive oxygen species production, mitochondrial dysfunction, and endoplasmic reticulum stress responses, leading to cell apoptosis.
Article
Environmental Sciences
Jian Li, Xin Dong, Jia-Yu Liu, Lan Gao, Yi-Chao Huang, Yan Wang, Hua Wang, Wei Wei, De-Xiang Xu
Summary: This study found that exposure to 1-Nitropyrene (1-NP) may partially contribute to placental P4 synthesis inhibition and IUGR through inducing FUNDC1-mediated mitophagy.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)