Inhibitors of bacterial H2S biogenesis targeting antibiotic resistance and tolerance

Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success

(2021) Markus Huemer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biology of antimicrobial resistance and approaches to combat it

(2020) Sarah M. Schrader et al.   Science Translational Medicine

The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

(2020) Brenna J. C. Walsh et al.   mBio

Mycobacterium tuberculosis metC (Rv3340) derived hydrogen sulphide conferring bacteria stress survival

(2019) Lambert Nzungize et al.   JOURNAL OF DRUG TARGETING

Definitions and guidelines for research on antibiotic persistence

(2019) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase–dependent hydrogen sulfide synthesis

(2019) Pramod K. Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

General Mechanisms Leading to Persister Formation and Awakening

(2019) Dorien Wilmaerts et al.   TRENDS IN GENETICS

Cysteine homeostasis under inhibition of protein synthesis in Escherichia coli cells

(2019) Galina V. Smirnova et al.   AMINO ACIDS

Antibiotic efficacy varies based on the infection model and treatment regimen for Pseudomonas aeruginosa

(2019) Cristina Cigana et al.   EUROPEAN RESPIRATORY JOURNAL

Bacterial Heterogeneity and Antibiotic Survival: Understanding and Combatting Persistence and Heteroresistance

(2019) Liselot Dewachter et al.   MOLECULAR CELL

Crystal Structure of Bacterial Cystathionine Γ-Lyase in The Cysteine Biosynthesis Pathway of Staphylococcus aureus

(2019) Dukwon Lee et al.   Crystals

A timeline of hydrogen sulfide (H 2 S) research: From environmental toxin to biological mediator

(2018) Csaba Szabo   BIOCHEMICAL PHARMACOLOGY

Pseudomonas aeruginosa MutL promotes large chromosomal deletions through non-homologous end joining to prevent bacteriophage predation

(2018) Mengyu Shen et al.   NUCLEIC ACIDS RESEARCH

Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l -threonine aldolase from Aeromonas jandaei

(2018) Kateryna Fesko et al.   FEBS Open Bio

H2S, a Bacterial Defense Mechanism against the Host Immune Response

(2018) Tracy Toliver-Kinsky et al.   INFECTION AND IMMUNITY

Structural Insights into Substrate Specificity of Cystathionine γ-Synthase from Corynebacterium glutamicum

(2017) Hye-Young Sagong et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis

(2017) Simon Davis et al.   JOURNAL OF PROTEOME RESEARCH

Mechanism of H2S-mediated protection against oxidative stress inEscherichia coli

(2017) Alexander Mironov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-Dependent Persister Formation in Escherichia coli

(2017) Yue Shan et al.   mBio

A case of mistaken identity: are reactive oxygen species actually reactive sulfide species?

(2016) Eric R. DeLeon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Efficacy of the Novel Antibiotic POL7001 in Preclinical Models of Pseudomonas aeruginosa Pneumonia

(2016) Cristina Cigana et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells formed against Antituberculosis Drugs In Vitro

(2016) Jees Sebastian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A TICT-based fluorescent probe for rapid and specific detection of hydrogen sulfide and its bio-imaging applications

(2016) Mingguang Ren et al.   CHEMICAL COMMUNICATIONS

Molecular mechanisms and clinical implications of bacterial persistence

(2016) Joran Elie Michiels et al.   DRUG RESISTANCE UPDATES

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

The Terminal Oxidase Cytochrome bd Promotes Sulfide-resistant Bacterial Respiration and Growth

(2016) Elena Forte et al.   Scientific Reports

Unraveling the Physiological Complexities of Antibiotic Lethality

(2015) Daniel J. Dwyer et al.   Annual Review of Pharmacology and Toxicology

Signaling of Hydrogen Sulfide and Polysulfides

(2015) Hideo Kimura   ANTIOXIDANTS & REDOX SIGNALING

PockDrug: A Model for Predicting Pocket Druggability That Overcomes Pocket Estimation Uncertainties

(2015) Alexandre Borrel et al.   Journal of Chemical Information and Modeling

Collective antibiotic tolerance: mechanisms, dynamics and intervention

(2015) Hannah R Meredith et al.   Nature Chemical Biology

Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation

(2015) Theerthankar Das et al.   Scientific Reports

Staphylococcus aureuschronic and relapsing infections: Evidence of a role for persister cells

(2014) Brian P. Conlon   BIOESSAYS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Bacterial gasotransmitters: an innate defense against antibiotics

(2014) Lyly Luhachack et al.   CURRENT OPINION IN MICROBIOLOGY

Moving forward with reactive oxygen species involvement in antimicrobial lethality

(2014) X. Zhao et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Optimization of tetrazolium salt assay for Pseudomonas aeruginosa biofilm using microtiter plate method

(2014) Parastoo Sabaeifard et al.   JOURNAL OF MICROBIOLOGICAL METHODS

PLP undergoes conformational changes during the course of an enzymatic reaction

(2014) Ho-Phuong-Thuy Ngo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Arrested Protein Synthesis Increases Persister-Like Cell Formation

(2013) Brian W. Kwan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)

(2013) Antonia Asimakopoulou et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fluorescent Probes Based on Nucleophilic Substitution-Cyclization for Hydrogen Sulfide Detection and Bioimaging

(2013) Bo Peng et al.   CHEMISTRY-A EUROPEAN JOURNAL

MOLE 2.0: advanced approach for analysis of biomacromolecular channels

(2013) David Sehnal et al.   Journal of Cheminformatics

The Relative Contributions of Physical Structure and Cell Density to the Antibiotic Susceptibility of Bacteria in Biofilms

(2012) Amy E. Kirby et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections

(2012) Balázs Rada et al.   TRENDS IN MICROBIOLOGY

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

(2011) Matthew Whiteman et al.   CLINICAL SCIENCE

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

H2S: A Universal Defense Against Antibiotics in Bacteria

(2011) K. Shatalin et al.   SCIENCE

Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms

(2011) Steven L. Percival et al.   WOUND REPAIR AND REGENERATION

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein–protein interactions

(2010) Catherine Joce et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The immune system vs.Pseudomonas aeruginosabiofilms

(2010) Peter Østrup Jensen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Murine models of acute and chronic lung infection with cystic fibrosis pathogens

(2010) Alessandra Bragonzi   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Pseudomonas aeruginosa Increases Formation of Multidrug-Tolerant Persister Cells in Response to Quorum-Sensing Signaling Molecules

(2010) N. Moker et al.   JOURNAL OF BACTERIOLOGY

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

(2010) Jonathan Lowther et al.   Molecular BioSystems

fpocket: online tools for protein ensemble pocket detection and tracking

(2010) P. Schmidtke et al.   NUCLEIC ACIDS RESEARCH

Fpocket: An open source platform for ligand pocket detection

(2009) Vincent Le Guilloux et al.   BMC BIOINFORMATICS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Site-Directed Mutagenesis on Human Cystathionine-γ-Lyase Reveals Insights into the Modulation of H2S Production

(2009) Shufen Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for the Inhibition Mechanism of Human Cystathionine γ-Lyase, an Enzyme Responsible for the Production of H2S

(2008) Qingxiang Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages

(2008) K. Shatalin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox-Active Antibiotics Control Gene Expression and Community Behavior in Divergent Bacteria

(2008) L. E. P. Dietrich et al.   SCIENCE