Conformational Dynamics Analysis of MEK1 Using Hydrogen/Deuterium Exchange Mass Spectrometry

Architecture of autoinhibited and active BRAF–MEK1–14-3-3 complexes

(2019) Eunyoung Park et al.   NATURE

Conformations of JNK3α splice variants analyzed by hydrogen/deuterium exchange mass spectrometry

(2017) Ji Young Park et al.   JOURNAL OF STRUCTURAL BIOLOGY

A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7

(2016) Yuri Sogabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recent progress on MAP kinase pathway inhibitors

(2015) David E. Uehling et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry

(2015) Nguyen Minh Duc et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

HDX-MS takes centre stage at unravelling kinase dynamics

(2014) Kristina Lorenzen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphorylation- and Nucleotide-Binding-Induced Changes to the Stability and Hydrogen Exchange Patterns of JNK1β1 Provide Insight into Its Mechanisms of Activation

(2014) Gavin R. Owen et al.   JOURNAL OF MOLECULAR BIOLOGY

Assessment of differences in the conformational flexibility of hepatitis B virus core-antigen and e-antigen by hydrogen deuterium exchange-mass spectrometry

(2014) Jessica Z. Bereszczak et al.   PROTEIN SCIENCE

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module

(2013) Gábor Glatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra

(2013) Miklos Guttman et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

MAP kinase signalling cascades and transcriptional regulation

(2012) Shen-Hsi Yang et al.   GENE

Hydrogen/deuterium exchange reflects binding of human centrin 2 to Ca2+ and Xeroderma pigmentosum Group C peptide: An example of EX1 kinetics

(2012) Justin B. Sperry et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

(2012) A. Garai et al.   Science Signaling

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

MEK1/2 dual-specificity protein kinases: Structure and regulation

(2011) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Escherichia coliProcessivity Clamp β from DNA Polymerase III Is Dynamic in Solution

(2011) Jing Fang et al.   BIOCHEMISTRY

Conformational Transitions in the Membrane Scaffold Protein of Phospholipid Bilayer Nanodiscs

(2011) Christopher R. Morgan et al.   MOLECULAR & CELLULAR PROTEOMICS

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

Hydrogen exchange mass spectrometry: what is it and what can it tell us?

(2010) Sean R. Marcsisin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state

(2010) Takashi Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct patterns of activation-dependent changes in conformational mobility between ERK1 and ERK2

(2010) Adam Y. Ring et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

False EX1 signatures caused by sample carryover during HX MS analyses

(2010) Jing Fang et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors

(2009) Thierry O. Fischmann et al.   BIOCHEMISTRY

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

(2009) Xiaoshan Min et al.   STRUCTURE

Hydrogen-Exchange Mass Spectrometry Reveals Activation-Induced Changes in the Conformational Mobility of p38α MAP Kinase

(2008) Kevin M. Sours et al.   JOURNAL OF MOLECULAR BIOLOGY