Identification of simple arylfluorosulfates as potent agents against resistant bacteria

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores From 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

(2020) Christopher J Smedley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SuFEx-enabled high-throughput medicinal chemistry

(2020) Seiya Kitamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Resveratrol – A comprehensive review of recent advances in anticancer drug design and development

(2020) Reza Ahmadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery

(2020) Gabriel J. Brighty et al.   Nature Chemistry

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

(2019) Mike Tyers et al.   NATURE REVIEWS MICROBIOLOGY

Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4 )-Derived Connective Hubs for Bioconjugation to DNA and Proteins

(2019) Feng Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

(2019) Qinheng Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining and combating antibiotic resistance from One Health and Global Health perspectives

(2019) Sara Hernando-Amado et al.   Nature Microbiology

Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy

(2019) Carlo Baggio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Honokiol: A Review of Its Anticancer Potential and Mechanisms

(2019) Chon Phin Ong et al.   Cancers

SuFEx Chemistry of Thionyl Tetrafluoride (SOF4 ) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates

(2018) Bing Gao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization

(2018) Zilei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

SuFEx Postpolymerization Modification Kinetics and Reactivity in Polymer Brushes

(2018) Karson Brooks et al.   MACROMOLECULES

Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens

(2018) Stephen Baker et al.   SCIENCE

The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms

(2018) Anna de Breij et al.   Science Translational Medicine

Aryl fluorosulfate analogues as potent antimicrobial agents: SAR, cytotoxicity and docking studies

(2018) Lekkala Ravindar et al.   BIOORGANIC CHEMISTRY

A new class of synthetic retinoid antibiotics effective against bacterial persisters

(2018) Wooseong Kim et al.   NATURE

The antibiotic resistance crisis, with a focus on the United States

(2017) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity

(2017) Baoli Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA)

(2017) Shuimu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

(2017) David E. Mortenson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates

(2017) Bing Gao et al.   Nature Chemistry

Targeting microbial biofilms: current and prospective therapeutic strategies

(2017) Hyun Koo et al.   NATURE REVIEWS MICROBIOLOGY

A study of the reactivity of S(VI)–F containing warheads with nucleophilic amino-acid side chains under physiological conditions

(2017) H. Mukherjee et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry

(2016) Hua-Li Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development and validation of an analytical method for the determination of 4-hexylresorcinol in food

(2016) Young-Hyun Kim et al.   FOOD CHEMISTRY

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

(2016) Wentao Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Antibiotic-Induced Changes in the Intestinal Microbiota and Disease

(2016) Simone Becattini et al.   TRENDS IN MOLECULAR MEDICINE

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

(2016) Amy Langdon et al.   Genome Medicine

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

(2015) Erik C. Hett et al.   ACS Chemical Biology

SuFEx on the Surface: A Flexible Platform for Postpolymerization Modification of Polymer Brushes

(2015) Jeremy Yatvin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Membrane Active Small Molecules Show Selective Broad Spectrum Antibacterial Activity with No Detectable Resistance and Eradicate Biofilms

(2015) Jiaul Hoque et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nonpeptidic Amphiphilic Xanthone Derivatives: Structure–Activity Relationship and Membrane-Targeting Properties

(2015) Jun-Jie Koh et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans

(2015) Aleksandra Baranczak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

Nickel- and Palladium-Catalyzed Coupling of Aryl Fluorosulfonates with Aryl Boronic Acids Enabled by Sulfuryl Fluoride

(2015) Patrick S. Hanley et al.   ACS Catalysis

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

(2014) Jiajia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SuFEx-Based Synthesis of Polysulfates

(2014) Jiajia Dong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

(2014) Casey M. Theriot et al.   Nature Communications

Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation

(2010) L. Dethlefsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium

(2009) G. A. McKay et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY