Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis

Therapeutic potential of PPARγ natural agonists in liver diseases

(2020) Liwei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice

(2020) Kei Ishizuka et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model

(2020) Xiangming Tang et al.   NEUROCHEMICAL RESEARCH

Impaired integrin α 5 /β 1 ‐mediated hepatocyte growth factor release by stellate cells of the aged liver

(2020) Friederike Rohn et al.   AGING CELL

Discovery of novel dual PPARα/δ agonists based on benzimidazole scaffold for the treatment of non-alcoholic fatty liver disease

(2020) Zheng Li et al.   BIOORGANIC CHEMISTRY

Elafibranor Interrupts Adipose Dysfunction-mediated Gut and Liver Injury in Mice with Alcoholic Steatohepatitis

(2019) Tzu-Hao Li et al.   CLINICAL SCIENCE

PPARβ/δ agonist GW501516 inhibits TNFα-induced repression of adiponectin and insulin receptor in 3T3-L1 adipocytes

(2019) Won Jun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effects of oleoylethanolamide, an endogenous PPAR‐α agonist, on risk factors for NAFLD: A systematic review

(2019) Helda Tutunchi et al.   Obesity Reviews

The dual PPAR-α/γ agonist saroglitazar ameliorates thioacetamide-induced liver fibrosis in rats through regulating leptin

(2019) Mirhan N. Makled et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Chrysin ameliorates nonalcoholic fatty liver disease in rats

(2019) Sarayu A. Pai et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

PPAR-γ agonist GL516 reduces oxidative stress and apoptosis occurrence in a rat astrocyte cell line

(2019) Letizia Giampietro et al.   NEUROCHEMISTRY INTERNATIONAL

Acanthoic acid modulates lipogenesis in nonalcoholic fatty liver disease via FXR/LXRs-dependent manner

(2019) Xin Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner

(2019) Jianlin He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease

(2019) Boyer-Diaz et al.   Nutrients

Alpha‐linolenic acid given as an anti‐inflammatory agent in a mouse model of colonic inflammation

(2019) Juan Wen et al.   Food Science & Nutrition

Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present)

(2019) Ichiro Takada et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Beneficial Effects of the Peroxisome Proliferator-Activated Receptor α/γ Agonist Aleglitazar on Progressive Hepatic and Splanchnic Abnormalities in Cirrhotic Rats with Portal Hypertension

(2018) Hung-Cheng Tsai et al.   AMERICAN JOURNAL OF PATHOLOGY

PPARγ alleviated hepatocyte steatosis through reducing SOCS3 by inhibiting JAK2/STAT3 pathway

(2018) Jian Bi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A PPAR Pan Agonist, MHY2013 Alleviates Age-Related Hepatic Lipid Accumulation by Promoting Fatty Acid Oxidation and Suppressing Inflammation

(2018) Hye Jin An et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Pioglitazone attenuates aging-related disorders in aged apolipoprotein E deficient mice

(2018) Dan Shen et al.   EXPERIMENTAL GERONTOLOGY

GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr−/− mice

(2018) Jacqueline C. Silva et al.   INTERNATIONAL JOURNAL OF OBESITY

PPARγ activation mitigates glucocorticoid receptor-induced excessive lipolysis in adipocytes via homeostatic crosstalk

(2018) Arif U. Hasan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides

(2018) Foteini Malliou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

GW0742 (PPAR-beta agonist) attenuates hepatic endoplasmic reticulum stress by improving hepatic energy metabolism in high-fat diet fed mice

(2018) Flavia Maria Silva-Veiga et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action

(2018) Eleonora Scorletti et al.   MOLECULAR ASPECTS OF MEDICINE

Liver fibrosis

(2018) M. Merve Aydin et al.   Turkish Journal of Gastroenterology

Calcitriol Inhibits HCV Infection via Blockade of Activation of PPAR and Interference with Endoplasmic Reticulum-Associated Degradation

(2018) Yu-Min Lin et al.   Viruses-Basel

Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

(2018) Mohammad Zarei et al.   Molecular Metabolism

The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice

(2018) Masaya Araki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

The nuclear receptor superfamily: A structural perspective

(2018) Emily R. Weikum et al.   PROTEIN SCIENCE

The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity

(2018) Aniket Nikam et al.   Scientific Reports

A role of peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease

(2018) Josephine Skat-Rørdam et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Liver as a target of human immunodeficiency virus infection

(2018) Murali Ganesan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Modulation of hepatic stellate cells and reversibility of hepatic fibrosis

(2017) Yu Huang et al.   EXPERIMENTAL CELL RESEARCH

Pioglitazone for advanced fibrosis in nonalcoholic steatohepatitis: New evidence, new challenges

(2017) Giovanni Musso et al.   HEPATOLOGY

Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation

(2017) Jae Ho Choi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The role of various peroxisome proliferator-activated receptors and their ligands in clinical practice

(2017) Giuseppe Derosa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation

(2017) Camila O. de Souza et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

PPARγ in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation

(2017) Samuel Philip Nobs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adiponectin regulates aquaglyceroporin expression in hepatic stellate cells altering their functional state

(2017) Matteo Tardelli et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

(2017) Teresa Ramirez et al.   JOURNAL OF HEPATOLOGY

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Liver Sinusoidal Endothelial Cell: An Update

(2017) Ana Maretti-Mira et al.   SEMINARS IN LIVER DISEASE

Regression of Liver Fibrosis

(2017) John Iredale et al.   SEMINARS IN LIVER DISEASE

Protective effect of rosiglitazone against acetaminophen-induced acute liver injury is associated with down-regulation of hepatic NADPH oxidases

(2017) Jun-Xian Wang et al.   TOXICOLOGY LETTERS

Key role of liver sinusoidal endothelial cells in liver fibrosis

(2017) Mingxing Xu et al.   BioScience Trends

Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR-γ

(2017) Da Zhou et al.   Experimental and Therapeutic Medicine

Effects of telmisartan on improving leptin resistance and inhibiting hepatic fibrosis in rats with non-alcoholic fatty liver disease

(2017) Qiu-Zan Zhang et al.   Experimental and Therapeutic Medicine

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

(2017) Wenjing Luo et al.   Scientific Reports

Acanthoic Acid Can Partially Prevent Alcohol Exposure-Induced Liver Lipid Deposition and Inflammation

(2017) You-Li Yao et al.   Frontiers in Pharmacology

Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice

(2016) In Hee Kim et al.   AGE

Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?

(2016) Swetha Rudraiah et al.   Annual Review of Pharmacology and Toxicology

New Developments on the Treatment of Liver Fibrosis

(2016) Yukinori Koyama et al.   DIGESTIVE DISEASES

Fatty acids, eicosanoids and PPAR gamma

(2016) Rachel Marion-Letellier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Peroxisome proliferator-activated receptor (PPAR) α and δ activators induce ICAM-1 expression in quiescent non stimulated endothelial cells

(2016) Julia Naidenow et al.   Journal of Inflammation-London

PPARγ Regulates Mouse Meibocyte Differentiation and Lipid Synthesis

(2016) James V. Jester et al.   Ocular Surface

Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice

(2016) Gayathri Balandaram et al.   TOXICOLOGY

Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets

(2016) Chong-Yang Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence

(2016) H Jin et al.   Cell Death & Disease

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

(2016) Xiujing Feng et al.   EBioMedicine

Fibrates and cholestasis

(2015) Nisanne S. Ghonem et al.   HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

PPARγand the Innate Immune System Mediate the Resolution of Inflammation

(2015) Amanda Croasdell et al.   PPAR Research

Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation

(2015) Lu Zhao et al.   Food & Function

Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging

(2015) Dan Li et al.   EJNMMI Research

Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ

(2014) Xiujing Feng et al.   BIOCHEMICAL PHARMACOLOGY

Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update

(2014) Gülsüm Özlem Elpek   WORLD JOURNAL OF GASTROENTEROLOGY

Liver diseases and aging: friends or foes?

(2013) Fareeba Sheedfar et al.   AGING CELL

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway

(2013) Chao Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Hepatic stellate cells hold the key to liver fibrosis

(2013) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

Peroxisome Proliferator-Activated Receptor and Vitamin D Receptor Signaling Pathways in Cancer Cells

(2013) Satoru Matsuda et al.   Cancers

Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside

(2012) Feng Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aging promotes the development of diet-induced murine steatohepatitis but not steatosis

(2012) Luis Fontana et al.   HEPATOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protection from liver fibrosis by a peroxisome proliferator-activated receptor   agonist

(2012) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

(2012) Yongzhong Hou et al.   Nature Communications

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

(2012) Radina Kostadinova et al.   Cell and Bioscience

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Roles of PPARs in NAFLD: Potential therapeutic targets

(2011) Anne Tailleux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Generation and characterization of a humanized PPARδ mouse model

(2011) B Gross et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of bezafibrate in nonalcoholic steatohepatitis model mice with monosodium glutamate-induced metabolic syndrome

(2011) Yoshiyuki Sasaki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

(2011) Zheng Wang et al.   Hepatobiliary & Pancreatic Diseases International

SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts

(2011) Barbara Renga et al.   INFLAMMATION RESEARCH

Liver fibrogenesis and metabolic factors

(2011) Rodolphe Anty et al.   Clinics and Research in Hepatology and Gastroenterology

Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARγ agonist KR62776

(2010) Myung-Ae Bae et al.   ARCHIVES OF PHARMACAL RESEARCH

PPARγ inhibits inflammatory reaction in oxidative stress induced human diploid fibloblast

(2010) Young-Hee Lee et al.   CELL BIOCHEMISTRY AND FUNCTION

Metabolic and nonmetabolic regulatory functions of peroxisome proliferator-activated receptor β

(2010) Paul A Grimaldi   CURRENT OPINION IN LIPIDOLOGY

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

PPARγ is essential for protection against nonalcoholic steatohepatitis

(2010) C W Wu et al.   GENE THERAPY

Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice

(2010) Anisha A. Gupte et al.   HEPATOLOGY

Effectiveness of the PPARγ agonist, GW570, in liver fibrosis

(2010) Liu Yang et al.   INFLAMMATION RESEARCH

Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro

(2010) Jun Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokines in Liver Inflammation and Fibrosis

(2010) Hermann Wasmuth et al.   SEMINARS IN LIVER DISEASE

Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease

(2009) Judit Marsillach et al.   BMC GASTROENTEROLOGY

PPAR -mediated macrophage activation: a matter of fat

(2009) T. T. Schug et al.   Disease Models & Mechanisms

PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR−/− mice

(2009) Hyun-Joung Lim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

PPARδ is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

(2009) Kim Ravnskjaer et al.   JOURNAL OF LIPID RESEARCH

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

PPARδ/β: The Lobbyist Switching Macrophage Allegiance in Favor of Metabolism

(2008) Béatrice Desvergne   Cell Metabolism

Peroxisome Proliferator-Activated Receptor-γ–Mediated Effects in the Vasculature

(2008) Sheng Zhong Duan et al.   CIRCULATION RESEARCH

A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease

(2008) C. Fernández-Miranda et al.   DIGESTIVE AND LIVER DISEASE

Systemic and Distal Repercussions of Liver-Specific Peroxisome Proliferator-Activated Receptor-α Control of the Acute-Phase Response

(2008) Roxane M. Mansouri et al.   ENDOCRINOLOGY

Mechanisms of Fibrogenesis

(2008) Tatiana Kisseleva et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Peroxisome proliferator-activated receptor-δ induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice

(2008) Rajeev Sharma et al.   HEPATOLOGY

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Fibrates and future PPARα agonists in the treatment of cardiovascular disease

(2008) Bart Staels et al.   Nature clinical practice. Cardiovascular medicine