Combating chronic bacterial infections by manipulating cyclic nucleotide-regulated biofilm formation

Membrane-anchored MucR mediates nitrate-dependent regulation of alginate production in Pseudomonas aeruginosa

(2015) Yajie Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP

(2015) Henrik Almblad et al.   JOURNAL OF BACTERIOLOGY

Bacterial Rotary Export ATPases Are Allosterically Regulated by the Nucleotide Second Messenger Cyclic-di-GMP

(2015) Eleftheria Trampari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligoribonuclease is a central feature of cyclic diguanylate signaling inPseudomonas aeruginosa

(2015) Dorit Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligoribonuclease is the primary degradative enzyme for pGpG inPseudomonas aeruginosathat is required for cyclic-di-GMP turnover

(2015) Mona W. Orr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

(2015) TuAnh Ngoc Huynh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of bacterial exoelectrogenesis by c-AMP-GMP

(2015) James W. Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The LapG protein plays a role inPseudomonas aeruginosabiofilm formation by controlling the presence of the CdrA adhesin on the cell surface

(2015) Morten Rybtke et al.   MicrobiologyOpen

Deletion Mutant Library for Investigation of Functional Outputs of Cyclic Diguanylate Metabolism in Pseudomonas aeruginosa PA14

(2014) Dae-Gon Ha et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tetrameric c-di-GMP Mediates Effective Transcription Factor Dimerization to Control Streptomyces Development

(2014) Natalia Tschowri et al.   CELL

Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases

(2014) Nicolas Barraud et al.   CURRENT PHARMACEUTICAL DESIGN

Genetics and regulation of bacterial alginate production

(2014) Iain D. Hay et al.   ENVIRONMENTAL MICROBIOLOGY

The Diguanylate Cyclase SadC Is a Central Player in Gac/Rsm-Mediated Biofilm Formation in Pseudomonas aeruginosa

(2014) J. A. Moscoso et al.   JOURNAL OF BACTERIOLOGY

The Diguanylate Cyclase GcbA Facilitates Pseudomonas aeruginosa Biofilm Dispersion by Activating BdlA

(2014) Olga E. Petrova et al.   JOURNAL OF BACTERIOLOGY

Cyclic Di-GMP-Mediated Repression of Swarming Motility by Pseudomonas aeruginosa PA14 Requires the MotAB Stator

(2014) S. L. Kuchma et al.   JOURNAL OF BACTERIOLOGY

BrlR fromPseudomonas aeruginosais a c-di-GMP-responsive transcription factor

(2014) Jacob R. Chambers et al.   MOLECULAR MICROBIOLOGY

Diguanylate cyclase NicD-based signalling mechanism of nutrient-induced dispersion byPseudomonas aeruginosa

(2014) Ankita Basu Roy et al.   MOLECULAR MICROBIOLOGY

Identification of flgZ as a Flagellar Gene Encoding a PilZ Domain Protein That Regulates Swimming Motility and Biofilm Formation in Pseudomonas

(2014) Francisco Martínez-Granero et al.   PLoS One

Dispersed cells represent a distinct stage in the transition from bacterial biofilm to planktonic lifestyles

(2014) Song Lin Chua et al.   Nature Communications

BdlA, DipA and Induced Dispersion Contribute to Acute Virulence and Chronic Persistence of Pseudomonas aeruginosa

(2014) Yi Li et al.   PLoS Pathogens

Novel Cyclic di-GMP Effectors of the YajQ Protein Family Control Bacterial Virulence

(2014) Shi-qi An et al.   PLoS Pathogens

High-Throughput Screening Using the Differential Radial Capillary Action of Ligand Assay Identifies Ebselen As an Inhibitor of Diguanylate Cyclases

(2013) Ori J. Lieberman et al.   ACS Chemical Biology

The role of bacterial biofilms in chronic infections

(2013) Thomas Bjarnsholt   APMIS

Optimal dosing regimen of nitric oxide donor compounds for the reduction of Pseudomonas aeruginosa biofilm and isolates from wastewater membranes

(2013) Robert J. Barnes et al.   BIOFOULING

Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development

(2013) Karthik Sambanthamoorthy et al.   BIOFOULING

A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis

(2013) Shi-Qi An et al.   EMBO JOURNAL

Clearance of Pseudomonas aeruginosa Foreign-Body Biofilm Infections through Reduction of the Cyclic Di-GMP Level in the Bacteria

(2013) Louise D. Christensen et al.   INFECTION AND IMMUNITY

NO-Induced Biofilm Dispersion in Pseudomonas aeruginosa Is Mediated by an MHYT Domain-Coupled Phosphodiesterase

(2013) Y. Li et al.   JOURNAL OF BACTERIOLOGY

The Putative Enoyl-Coenzyme A Hydratase DspI Is Required for Production of the Pseudomonas aeruginosa Biofilm Dispersion Autoinducer cis-2-Decenoic Acid

(2013) D. T. Amari et al.   JOURNAL OF BACTERIOLOGY

Structure of the PilZ–FimXEAL–c-di-GMP Complex Responsible for the Regulation of Bacterial Type IV Pilus Biogenesis

(2013) Cristiane R. Guzzo et al.   JOURNAL OF MOLECULAR BIOLOGY

RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messengers Cyclic di-GMP and Cyclic AMP-GMP

(2013) Colleen A. Kellenberger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Applying insights from biofilm biology to drug development — can a new approach be developed?

(2013) Thomas Bjarnsholt et al.   NATURE REVIEWS DRUG DISCOVERY

Cyclic di-AMP: another second messenger enters the fray

(2013) Rebecca M. Corrigan et al.   NATURE REVIEWS MICROBIOLOGY

Cyclic diguanosine monophosphate represses bacterial flagella synthesis by interacting with the Walker A motif of the enhancer-binding protein FleQ

(2013) C. Baraquet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The in vivo biofilm

(2013) Thomas Bjarnsholt et al.   TRENDS IN MICROBIOLOGY

Subcellular Clustering of the Phosphorylated WspR Response Regulator Protein Stimulates Its Diguanylate Cyclase Activity

(2013) V. Huangyutitham et al.   mBio

Identification of Small Molecules That Antagonize Diguanylate Cyclase Enzymes To Inhibit Biofilm Formation

(2012) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa

(2012) Morten T. Rybtke et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae Virulence

(2012) Bryan W. Davies et al.   CELL

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis

(2012) Dimpy Kalia et al.   CHEMICAL SOCIETY REVIEWS

Towards diagnostic guidelines for biofilm-associated infections

(2012) Luanne Hall-Stoodley et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production inPseudomonas aeruginosa

(2012) John C. Whitney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A review of the scientific evidence for biofilms in wounds

(2012) Steven L. Percival et al.   WOUND REPAIR AND REGENERATION

Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner

(2011) Karthik Sambanthamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclic GMP controls Rhodospirillum centenum cyst development

(2011) Jeremiah N. Marden et al.   MOLECULAR MICROBIOLOGY

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Second Messenger-Mediated Adjustment of Bacterial Swimming Velocity

(2010) Alex Boehm et al.   CELL

In vitro and in vivo model systems to study microbial biofilm formation

(2010) Tom Coenye et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism

(2010) Koushik Paul et al.   MOLECULAR CELL

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

Principles of c-di-GMP signalling in bacteria

(2009) Regine Hengge   NATURE REVIEWS MICROBIOLOGY

MucR, a Novel Membrane-Associated Regulator of Alginate Biosynthesis in Pseudomonas aeruginosa

(2008) I. D. Hay et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Fatty Acid Messenger Is Responsible for Inducing Dispersion in Microbial Biofilms

(2008) D. G. Davies et al.   JOURNAL OF BACTERIOLOGY