Development of novel aminothiazole-comprising 5-LO inhibitors

A phase 2 randomized, double-blind, placebo-controlled study of the effect of VIA-2291, a 5-lipoxygenase inhibitor, on vascular inflammation in patients after an acute coronary syndrome

(2015) Juan Gaztanaga et al.   ATHEROSCLEROSIS

The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer’s disease phenotype

(2015) Yash B. Joshi et al.   Frontiers in Cellular Neuroscience

Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase

(2014) Mirjam Schröder et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism

(2014) Carmen B. Rödl et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in the Search for Novel 5-Lipoxygenase Inhibitors

(2013) Dieter Steinhilber et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

A review on leukotrienes and their receptors with reference to asthma

(2013) Rakesh Kumar Singh et al.   JOURNAL OF ASTHMA

Identification of GPR99 Protein as a Potential Third Cysteinyl Leukotriene Receptor with a Preference for Leukotriene E4Ligand

(2013) Yoshihide Kanaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of N-aryl-4-aryl-1,3-Thiazole-2-Amine Derivatives as Direct 5-Lipoxygenase Inhibitors

(2012) Jeehee Suh et al.   Chemical Biology & Drug Design

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple Factors Govern the Association between Pharmacology and Toxicity in a Class of Drugs: Toward a Unification of Class Effect Terminology

(2011) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Structure of Human 5-Lipoxygenase

(2011) N. C. Gilbert et al.   SCIENCE

5-Lipoxygenase: Underappreciated Role of a Pro-Inflammatory Enzyme in Tumorigenesis

(2011) Dieter Steinhilber et al.   Frontiers in Pharmacology

2-ABT-S-oxide detoxification by glutathioneS-transferases A1-1, M1-1 and P1-1: Implications for toxicity associated with zileuton

(2009) E.M. Joshi et al.   XENOBIOTICA

Leukotriene modifiers in the treatment of cardiovascular diseases

(2008) Graziano Riccioni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES