Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy
Authors
Keywords
-
Journal
Future Medicinal Chemistry
Volume 8, Issue 17, Pages 2113-2142
Publisher
Future Science, LTD
Online
2016-10-24
DOI
10.4155/fmc-2016-0103
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Propargylamine Containing Compounds as Modulators of Proteolytic Cleavage of Amyloid Protein Precursor: Involvement of MAPK and PKC Activation
- (2017) Orit Bar-Am et al. JOURNAL OF ALZHEIMERS DISEASE
- Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo
- (2015) Anna Więckowska et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease
- (2015) Marek Bajda et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD
- (2015) Maria Digiacomo et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease
- (2015) Rangappa S. Keri et al. Chemical Biology & Drug Design
- Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies
- (2015) Jessica Nasica-Labouze et al. CHEMICAL REVIEWS
- Inhibition of protein aggregation and amyloid formation by small molecules
- (2015) Andrew J Doig et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry
- (2015) Rangappa S. Keri et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease
- (2015) Sai-Sai Xie et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Copper(II) complexation of tacrine hybrids with potential anti-neurodegenerative roles
- (2015) Catarina Quintanova et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride
- (2015) Christophe Rochais et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and bioevaluation of tacrine hybrids with cinnamate and cinnamylidene acetate derivatives as potential anti-Alzheimer drugs
- (2015) Catarina Quintanova et al. MedChemComm
- Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors
- (2014) Hayrettin Ozan Gulcan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer’s disease
- (2014) Jin-Shuai Lan et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Galantamine-based Hybrid Molecules with Acetylcholinesterase, Butyrylcholinesterase and γ-Secretase Inhibition Activities
- (2014) L. Vezenkov et al. Current Alzheimer Research
- Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease
- (2014) Natalia Guzior et al. CURRENT MEDICINAL CHEMISTRY
- Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease
- (2014) Angel Agis-Torres et al. Current Neuropharmacology
- The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics
- (2014) M. Carreiras et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Multifunctional Tacrine Derivatives in Alzheimer’s Disease
- (2014) Anna Minarini et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies
- (2014) Ornella Di Pietro et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular modeling study of novel tacrine–carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease
- (2014) Supatra Thiratmatrakul et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease
- (2014) Ling Huang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Indolinone-based acetylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling
- (2014) Hamidreza Akrami et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors
- (2014) Shuai Qian et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors
- (2014) Slavka Hamulakova et al. JOURNAL OF MEDICINAL CHEMISTRY
- Multitarget Drug Design Strategy: Quinone–Tacrine Hybrids Designed To Block Amyloid-β Aggregation and To Exert Anticholinesterase and Antioxidant Effects
- (2014) Eugenie Nepovimova et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and synthesis of tacrine-phenothiazine hybrids as multitarget drugs for Alzheimer’s disease
- (2014) Ai-ling Hui et al. MEDICINAL CHEMISTRY RESEARCH
- Donepezil: An Important Prototype to the Design of New Drug Candidates for Alzheimer’s Disease
- (2014) Maria Rodrigues Simoes et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Tacrine-Flurbiprofen Hybrids as Multifunctional Drug Candidates for the Treatment of Alzheimer's Disease
- (2013) Yao Chen et al. ARCHIV DER PHARMAZIE
- A review on cholinesterase inhibitors for Alzheimer’s disease
- (2013) Preet Anand et al. ARCHIVES OF PHARMACAL RESEARCH
- Tau-aggregation inhibitor therapy for Alzheimer's disease
- (2013) Claude M. Wischik et al. BIOCHEMICAL PHARMACOLOGY
- Design, synthesis and evaluation of tacrine–flurbiprofen–nitrate trihybrids as novel anti-Alzheimer’s disease agents
- (2013) Yao Chen et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine–Homoisoflavonoid hybrids
- (2013) Yang Sun et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole hybrids as multi-targeted compounds against Alzheimer’s disease
- (2013) Rangappa S. Keri et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer’s disease
- (2013) Alejandro Romero et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity
- (2013) Fei Mao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Shifting from the single to the multitarget paradigm in drug discovery
- (2013) José L. Medina-Franco et al. DRUG DISCOVERY TODAY
- Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease
- (2013) Abdelouahid Samadi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A novel series of tacrine–selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease
- (2013) Chuanjun Lu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease
- (2013) Sanghyun Lee et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Identification of a Common Binding Mode for Imaging Agents to Amyloid Fibrils from Molecular Dynamics Simulations
- (2013) Katrine Kirkeby Skeby et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Alzheimer disease therapy—moving from amyloid-β to tau
- (2013) Ezio Giacobini et al. Nature Reviews Neurology
- Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease
- (2013) Su-Yi Li et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways
- (2012) Tiago Silva et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities
- (2012) Masashi Shinada et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Novel multipotent phenylthiazole–tacrine hybrids for the inhibition of cholinesterase activity, β-amyloid aggregation and Ca2+ overload
- (2012) Yue Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: Multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-β aggregation
- (2012) Fei Mao et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids
- (2012) Ling Huang et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents
- (2012) Fan-Chao Meng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease
- (2012) Xiaojuan Chao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases
- (2012) L. Pisani et al. CURRENT MEDICINAL CHEMISTRY
- 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents
- (2012) Stefano Rizzo et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Acetylcholinesterase inhibitors: a patent review (2008 – present)
- (2012) Miroslav Pohanka EXPERT OPINION ON THERAPEUTIC PATENTS
- Cholinesterase inhibitors: a patent review (2007 – 2011)
- (2012) Cristóbal de los Ríos EXPERT OPINION ON THERAPEUTIC PATENTS
- Metallostasis in Alzheimer's disease
- (2012) Scott Ayton et al. FREE RADICAL BIOLOGY AND MEDICINE
- Multifunctional Mercapto-tacrine Derivatives for Treatment of Age-Related Neurodegenerative Diseases
- (2012) Yue Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tacrine-Silibinin Codrug Shows Neuro- and Hepatoprotective Effects in Vitro and Pro-Cognitive and Hepatoprotective Effects in Vivo
- (2012) Xinyu Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tacrine–Ferulic Acid–Nitric Oxide (NO) Donor Trihybrids as Potent, Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors
- (2012) Yao Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties
- (2012) María Isabel Fernández-Bachiller et al. JOURNAL OF MEDICINAL CHEMISTRY
- Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors
- (2012) Irene Bolea et al. JOURNAL OF NEURAL TRANSMISSION
- Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease
- (2012) Desiree Antequera et al. NEUROBIOLOGY OF DISEASE
- Inhibition of Beta-Amyloid Peptide Aggregation by Multifunctional Carbazole-Based Fluorophores
- (2011) Wanggui Yang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors
- (2011) Huang Tang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease
- (2011) Michela Rosini et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Homoisoflavonoids: Natural Scaffolds with Potent and Selective Monoamine Oxidase-B Inhibition Properties
- (2011) Nicoletta Desideri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil andN-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s Disease
- (2011) Irene Bolea et al. JOURNAL OF MEDICINAL CHEMISTRY
- Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases
- (2011) Carles Galdeano et al. JOURNAL OF MEDICINAL CHEMISTRY
- Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
- (2011) Rafael León et al. MEDICINAL RESEARCH REVIEWS
- Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment
- (2011) A. Minarini et al. NEUROPHARMACOLOGY
- Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase
- (2011) Joshua J. Bornstein et al. MedChemComm
- Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease
- (2010) Gary Small et al. Alzheimers & Dementia
- Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation
- (2010) Wen Luo et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Neuroprotective effects of bis(7)-tacrine against glutamate-induced retinal ganglion cells damage
- (2010) Jia Fang et al. BMC NEUROSCIENCE
- Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
- (2010) Pelayo Camps et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Novel Huprine Derivatives with Inhibitory Activity toward β-Amyloid Aggregation and Formation as Disease-Modifying Anti-Alzheimer Drug Candidates
- (2010) Elisabet Viayna et al. ChemMedChem
- Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1Receptors
- (2010) Lei Fang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1Receptor Antagonism
- (2010) Jos H. M. Lange et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Tacrine−8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing Properties
- (2010) María Isabel Fernández-Bachiller et al. JOURNAL OF MEDICINAL CHEMISTRY
- Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
- (2010) John C O'Leary et al. Molecular Neurodegeneration
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
- (2010) Jan Bieschke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defining and labeling disease-modifying treatments for Alzheimer's disease
- (2009) Jeffrey L. Cummings Alzheimers & Dementia
- Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
- (2009) Yiping Zhu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease
- (2009) Lauren E. Scott et al. CHEMICAL REVIEWS
- Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties
- (2009) María Isabel Fernández-Bachiller et al. ChemMedChem
- Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine
- (2009) V. Koteswara Rao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy
- (2009) Hailin Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks
- (2009) Maria Laura Bolognesi et al. JOURNAL OF MEDICINAL CHEMISTRY
- A novel effect of rivastigmine on pre-synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer’s disease
- (2009) Jason A. Bailey et al. JOURNAL OF NEUROCHEMISTRY
- Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates
- (2008) Lei Fang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors
- (2008) Ping Jia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates
- (2008) Lei Fang et al. JOURNAL OF MEDICINAL CHEMISTRY
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury
- (2008) P. Sompol et al. NEUROSCIENCE
- Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation
- (2008) Wolfgang Hoyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
- (2007) Tamar Amit et al. FASEB JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More