1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties

The Therapeutic Potential of α7 Nicotinic Acetylcholine Receptor (α7 nAChR) Agonists for the Treatment of the Cognitive Deficits Associated with Schizophrenia

(2015) Corinne Beinat et al.   CNS DRUGS

Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure

(2014) Beatriz Balsera et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects

(2014) JasKiran K. Gill-Thind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel 2-((Pyridin-3-yloxy)methyl)piperazines as α7 Nicotinic Acetylcholine Receptor Modulators for the Treatment of Inflammatory Disorders

(2014) Roger B. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant Activity of Galantamine and Some of its Derivatives

(2013) D. Tsvetkova et al.   CURRENT MEDICINAL CHEMISTRY

Chlorogenic acid administered intrathecally alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model

(2013) Koji Hara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expeditious Synthesis, Enantiomeric Resolution, and Enantiomer Functional Characterization of (4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): An Allosteric Agonist-Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors

(2013) Ganesh A. Thakur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Activity of a Series of Arylpyrid-3-ylmethanones as Type I Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors

(2013) Derk J. Hogenkamp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Involvement of α7 nAChR Signaling Cascade in Epigallocatechin Gallate Suppression of β-Amyloid-Induced Apoptotic Cortical Neuronal Insults

(2013) Xijing Zhang et al.   MOLECULAR NEUROBIOLOGY

The Antioxidant Effects of the Flavonoids Rutin and Quercetin Inhibit Oxaliplatin-Induced Chronic Painful Peripheral Neuropathy

(2013) Maria Isabel Azevedo et al.   Molecular Pain

In vivopharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model

(2012) K Freitas et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-[5-(5-Fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate

(2012) Riccardo Zanaletti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a Selective α7 Nicotinic Acetylcholine Receptor Agonist, for the Treatment of Cognitive Disorders

(2012) Anatoly A. Mazurov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models

(2012) Kelen Freitas et al.   NEUROPHARMACOLOGY

Beneficial effects of polyphenols on cardiovascular disease

(2012) Mar Quiñones et al.   PHARMACOLOGICAL RESEARCH

Cocoa and Chocolate in Human Health and Disease

(2011) David L. Katz et al.   ANTIOXIDANTS & REDOX SIGNALING

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxygen radical absorbance capacity (ORAC) of cyclodextrin-solubilized flavonoids, resveratrol and astaxanthin as measured with the ORAC-EPR method

(2011) Yoshimi Sueishi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Discovery and Development of α7 Nicotinic Acetylcholine Receptor Modulators

(2011) Anatoly A. Mazurov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Schizophrenia and tobacco smoking comorbidity: nAChR agonists in the treatment of schizophrenia-associated cognitive deficits

(2011) Manoranjan S. D’Souza et al.   NEUROPHARMACOLOGY

In Vitro Pharmacological Characterization of a Novel Selective  7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107

(2010) J. Malysz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor

(2009) Ramin Faghih et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of  7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile

(2009) J. Malysz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Old and New Pharmacology: Positive Allosteric Modulation of the  7 Nicotinic Acetylcholine Receptor by the 5-Hydroxytryptamine2B/C Receptor Antagonist SB-206553 (3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)

(2008) J. Dunlop et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Diversity of vertebrate nicotinic acetylcholine receptors

(2008) Neil S. Millar et al.   NEUROPHARMACOLOGY