MASTL regulates EGFR signaling to impact pancreatic cancer progression

AKT regulates mitotic progression of mammalian cells by phosphorylating MASTL leading to PP2A inactivation

(2020) Irfana Reshi et al.   MOLECULAR AND CELLULAR BIOLOGY

Pancreatic cancer

(2020) Jonathan D Mizrahi et al.   LANCET

MASTL: A novel therapeutic target for Cancer Malignancy

(2020) Iram Fatima et al.   Cancer Medicine

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

(2019) Marika Kucińska et al.   Cell Communication and Signaling

Correction: Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner

(2019) Saiprasad Gowrikumar et al.   ONCOGENE

Simultaneous Multi-Organ Metastases from Chemo-Resistant Triple-Negative Breast Cancer Are Prevented by Interfering with WNT-Signaling

(2019) Iram Fatima et al.   Cancers

MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells

(2018) Yi Na Yoon et al.   BMC CANCER

Zinc supplementation alleviates the progression of diabetic nephropathy by inhibiting the overexpression of oxidative-stress-mediated molecular markers in streptozotocin-induced experimental rats

(2018) Susmita Barman et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Galectin-8 induces partial epithelial–mesenchymal transition with invasive tumorigenic capabilities involving a FAK/EGFR/proteasome pathway in Madin–Darby canine kidney cells

(2018) Claudia Oyanadel et al.   MOLECULAR BIOLOGY OF THE CELL

MASTL overexpression promotes chromosome instability and metastasis in breast cancer

(2018) Samuel Rogers et al.   ONCOGENE

Correction: The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer

(2018) Iram Fatima et al.   PLoS One

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk

(2018) Carlos A. Orozco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of new inhibitors against human Great wall kinase using in silico approaches

(2018) Ummi Ammarah et al.   Scientific Reports

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

(2018) Srijayaprakash Babu Uppada et al.   Molecular Cancer

The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer

(2018) Ikbale El Ayachi et al.   CANCER RESEARCH

HH1-1, a novel Galectin-3 inhibitor, exerts anti-pancreatic cancer activity by blocking Galectin-3/EGFR/AKT/FOXO3 signaling pathway

(2018) Yanli Yao et al.   CARBOHYDRATE POLYMERS

Cell cycle-dependent regulation of Greatwall kinase by protein phosphatase 1 and regulatory subunit 3B

(2017) Dapeng Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

(2016) Pingping Li et al.   CELL

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct

(2016) Cory A. Ocasio et al.   Oncotarget

Galectin-3 modulates the EGFR signalling-mediated regulation of Sox2 expression via c-Myc in lung cancer

(2015) Hong-Yi Kuo et al.   GLYCOBIOLOGY

G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound

(2015) Maia Cabrera et al.   PLoS One

Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening

(2015) Maria Chiara Anania et al.   Oncotarget

Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

(2015) Jorge Vera et al.   eLife

Mastl kinase, a promising therapeutic target, promotes cancer recurrence

(2015) Ling Wang et al.   Oncotarget

Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry

(2014) Mónica Álvarez-Fernández et al.   BIOESSAYS

Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation

(2014) N. Martinez-Bosch et al.   CANCER RESEARCH

EGFR as a Potential Target for the Treatment of Pancreatic Cancer: Dilemma and Controversies

(2014) Reza Nedaeinia et al.   CURRENT DRUG TARGETS

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Novel Pancreatic Cancer Cell Lines Derived from Genetically Engineered Mouse Models of Spontaneous Pancreatic Adenocarcinoma: Applications in Diagnosis and Therapy

(2013) María P. Torres et al.   PLoS One

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

(2013) M. Alvarez-Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic cancer: why is it so hard to treat?

(2013) Paul E. Oberstein et al.   Therapeutic Advances in Gastroenterology

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration

(2012) Wei Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stable Government of Mitosis by Greatwall: the Emperor's Best Servant

(2012) E. Voets et al.   MOLECULAR AND CELLULAR BIOLOGY

The Greatwall kinase: a new pathway in the control of the cell cycle

(2012) T Lorca et al.   ONCOGENE

Galectin-3 Protein Modulates Cell Surface Expression and Activation of Vascular Endothelial Growth Factor Receptor 2 in Human Endothelial Cells

(2011) Anna I. Markowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor in Pancreatic Cancer

(2011) Melissa Oliveira-Cunha et al.   Cancers

MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

(2010) Erik Voets et al.   CELL CYCLE

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

(2009) Priscila V. Castilho et al.   MOLECULAR BIOLOGY OF THE CELL