G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound

Characterization of the anticancer effects of S115, a novel heteroaromatic thiosemicarbazone compound, in vitro and in vivo

(2014) Min-yu Liu et al.   ACTA PHARMACOLOGICA SINICA

Synthesis and antiproliferative activity of some steroidal thiosemicarbazones, semicarbazones and hydrozones

(2014) Chunfang Gan et al.   STEROIDS

Mechanistic insights into mode of action of novel natural cathepsin L inhibitors

(2013) Chetna Tyagi et al.   BMC GENOMICS

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers

(2013) Charles A. Kunos et al.   GYNECOLOGIC ONCOLOGY

APOLLON Protein Promotes Early Mitotic CYCLIN A Degradation Independent of the Spindle Assembly Checkpoint

(2013) Ryo Kikuchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Chelators with Topoisomerase-Inhibitory Activity and Their Anticancer Applications

(2012) V. Ashutosh Rao   ANTIOXIDANTS & REDOX SIGNALING

Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L

(2012) Gustavo E. Chavarria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A phase I study of prolonged infusion of triapine in combination with fixed dose rate gemcitabine in patients with advanced solid tumors

(2012) Amir Mortazavi et al.   INVESTIGATIONAL NEW DRUGS

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus

(2011) Cho Rong Han et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study

(2011) Joseph Chao et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-Heterocyclic-N4-Substituted Thiosemicarbazones and Their Cu(II) Complexes

(2011) Brian M. Zeglis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spindle Poisons and Cell Fate: A Tale of Two Pathways

(2011) D. R. Matson et al.   MOLECULAR INTERVENTIONS

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors

(2010) G.D. Kishore Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L

(2010) G.D. Kishore Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phase I Trial of Pelvic Radiation, Weekly Cisplatin, and 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone (3-AP, NSC #663249) for Locally Advanced Cervical Cancer

(2010) C. A. Kunos et al.   CLINICAL CANCER RESEARCH

A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity

(2010) He Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Molecular Response of HL-60 Cells to Mitotic Inhibitors Vincristine and Taxol Visualized with Apoptosis-Related Gene Expressions, Including the New Member BCL2L12

(2009) Hellinida Thomadaki et al.   Annals of the New York Academy of Sciences

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Thiosemicarbazones: the new wave in cancer treatment

(2009) Danuta S Kalinowski et al.   Future Medicinal Chemistry

Synthesis, characterization and deepening in the comprehension of the biological action mechanisms of a new nickel complex with antiproliferative activity

(2009) Annamaria Buschini et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity

(2009) Des R. Richardson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors

(2009) Yu Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

Organotin(IV) complexes of 2-pyridineformamide-derived thiosemicarbazones: Antimicrobial and cytotoxic effects

(2007) Isolda C. Mendes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New 1-indanone thiosemicarbazone derivatives active against BVDV

(2007) Liliana M. Finkielsztein et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY