The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers

CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy

(2019) Hirokazu Kimura et al.   CLINICAL CANCER RESEARCH

Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6

(2019) Ryota Sada et al.   Science Signaling

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug

(2018) Naoki Shinno et al.   ONCOGENE

p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4

(2018) Chihiro Kajiwara et al.   CANCER RESEARCH

Fox transcription factors: from development to disease

(2016) Maria L. Golson et al.   DEVELOPMENT

CKAP4 is a Dickkopf1 receptor and is involved in tumor progression

(2016) Hirokazu Kimura et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2

(2016) Hao Zhang et al.   TUMOR BIOLOGY

Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis

(2015) T. S. Karin Eisinger-Mathason et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum dickkopf-1 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer

(2015) Su-xia Han et al.   Oncotarget

Esophageal Carcinoma

(2014) Anil K. Rustgi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

(2013) Y. Zhang et al.   CANCER RESEARCH

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D

(2013) I-C Wang et al.   ONCOGENE

WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma

(2013) M D Arensman et al.   ONCOGENE

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

(2011) Nu Zhang et al.   CANCER CELL

Artificially Induced Epithelial-Mesenchymal Transition in Surgical Subjects: Its Implications in Clinical and Basic Cancer Research

(2011) Kazuhiko Aoyagi et al.   PLoS One

Human Dickkopf-1 (huDKK1) protein: Characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains

(2011) Mitsuru Haniu et al.   PROTEIN SCIENCE

A 4-Gene Signature Predicts Survival of Patients With Resected Adenocarcinoma of the Esophagus, Junction, and Gastric Cardia

(2010) Christopher J. Peters et al.   GASTROENTEROLOGY

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

(2010) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells

(2009) M. Hussain et al.   CANCER RESEARCH

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

(2009) Theresa A. DiMeo et al.   CANCER RESEARCH

FoxM1, a critical regulator of oxidative stress during oncogenesis

(2009) Hyun Jung Park et al.   EMBO JOURNAL

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL