Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6

CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy

(2019) Hirokazu Kimura et al.   CLINICAL CANCER RESEARCH

Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug

(2018) Naoki Shinno et al.   ONCOGENE

p63-dependent Dickkopf3 expression promotes esophageal cancer cell proliferation via CKAP4

(2018) Chihiro Kajiwara et al.   CANCER RESEARCH

Wnt5b-associated exosomes promote cancer cell migration and proliferation

(2016) Takeshi Harada et al.   CANCER SCIENCE

CKAP4 is a Dickkopf1 receptor and is involved in tumor progression

(2016) Hirokazu Kimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of PSD-95 Depalmitoylating Enzymes

(2016) Norihiko Yokoi et al.   JOURNAL OF NEUROSCIENCE

Epigenetic upregulation of ARL4C, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis of lung squamous cell carcinoma

(2016) Shinsuke Fujii et al.   Oncotarget

The Physiology of Protein S-acylation

(2015) Luke H. Chamberlain et al.   PHYSIOLOGICAL REVIEWS

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

(2015) David Tse Shen Lin et al.   eLife

A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures

(2014) S. Matsumoto et al.   EMBO JOURNAL

Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target

(2014) S Fujii et al.   ONCOGENE

What does S-palmitoylation do to membrane proteins?

(2013) Sanja Blaskovic et al.   FEBS Journal

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6

(2013) Kubilay Demir et al.   Cell Reports

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

(2012) Yong Jiang et al.   EMBO JOURNAL

Human Dickkopf-1 (huDKK1) protein: Characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains

(2011) Mitsuru Haniu et al.   PROTEIN SCIENCE

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

(2010) H. Sakane et al.   JOURNAL OF CELL SCIENCE

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Palmitoylation of Cytoskeleton Associated Protein 4 by DHHC2 Regulates Antiproliferative Factor-mediated Signaling

(2009) Sonia L. Planey et al.   MOLECULAR BIOLOGY OF THE CELL

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

(2008) Benjamin C. Jennings et al.   JOURNAL OF LIPID RESEARCH

Identification of CKAP4/p63 as a Major Substrate of the Palmitoyl Acyltransferase DHHC2, a Putative Tumor Suppressor, Using a Novel Proteomics Method

(2008) Jun Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

(2008) L. Abrami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA