Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations

FOXO4 Transactivation Domain Interaction with Forkhead DNA Binding Domain and Effect on Selective DNA Recognition for Transcription Initiation

(2021) Jinwoo Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of forkhead transcription factors binding to a novel palindromic DNA site

(2021) Jun Li et al.   NUCLEIC ACIDS RESEARCH

Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions

(2020) Ignacio L. Ibarra et al.   Nature Communications

FOXO transcription factor family in cancer and metastasis

(2020) Yannasittha Jiramongkol et al.   CANCER AND METASTASIS REVIEWS

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

(2020) Svetlana O. Dodonova et al.   NATURE

Mechanisms of OCT4-SOX2 motif readout on nucleosomes

(2020) Alicia K. Michael et al.   SCIENCE

The FOXO’s Advantages of Being a Family: Considerations on Function and Evolution

(2020) Michel Schmitt-Ney   Cells

FOXA1 Mutations Reveal Distinct Chromatin Profiles and Influence Therapeutic Response in Breast Cancer

(2020) Amaia Arruabarrena-Aristorena et al.   CANCER CELL

Structural basis for DNA recognition by FOXG1 and the characterization of disease-causing FOXG1 mutations

(2020) Shuyan Dai et al.   JOURNAL OF MOLECULAR BIOLOGY

Pioneer of prostate cancer: past, present and the future of FOXA1

(2020) Mona Teng et al.   Protein & Cell

Forkhead Transcription Factors in Health and Disease

(2020) Laetitia Herman et al.   TRENDS IN GENETICS

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

(2019) Paul Laissue   Molecular Cancer

Structural basis for DNA recognition by FOXC2

(2019) Xiaojuan Chen et al.   NUCLEIC ACIDS RESEARCH

Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes

(2019) Julia M. Rogers et al.   MOLECULAR CELL

An order-to-disorder structural switch activates the FoxM1 transcription factor

(2019) Aimee H Marceau et al.   eLife

Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression

(2019) Bohan Xu et al.   CELL RESEARCH

Forkhead domain mutations in FOXA1 drive prostate cancer progression

(2019) Shuai Gao et al.   CELL RESEARCH

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes

(2019) Elizabeth J. Adams et al.   NATURE

Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer

(2019) Abhijit Parolia et al.   NATURE

Cognition and Evolution of Movement Disorders of FOXG1-Related Syndrome

(2019) Lee-Chin Wong et al.   Frontiers in Neurology

Crystal Structure of FOXC2 in Complex with DNA Target

(2019) Shichang Li et al.   ACS Omega

Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics

(2019) Katarina Psenakova et al.   Cells

Conventional and unconventional interactions of the transcription factor FOXL2 uncovered by a proteome‐wide analysis

(2019) May Penrad‐Mobayed et al.   FASEB JOURNAL

FOXG1 Dose in Brain Development

(2019) Nuwan C. Hettige et al.   Frontiers in Pediatrics

The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity

(2019) Joseph A. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer

(2019) Xiaoyong Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression

(2018) Marten Hornsveld et al.   CANCER RESEARCH

The Human Transcription Factors

(2018) Samuel A. Lambert et al.   CELL

Axenfeld-Rieger syndrome

(2018) M. Seifi et al.   CLINICAL GENETICS

DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1

(2018) Xuecong Wang et al.   NUCLEIC ACIDS RESEARCH

The Dominant Role of Forkhead Box Proteins in Cancer

(2018) Duc-Hiep Bach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter

(2017) Puja Singh et al.   JOURNAL OF STRUCTURAL BIOLOGY

Emerging roles of linker histones in regulating chromatin structure and function

(2017) Dmitry V. Fyodorov et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FOXA1 inhibits prostate cancer neuroendocrine differentiation

(2017) J Kim et al.   ONCOGENE

Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes inS. cerevisiae

(2017) A. Zachary Ostrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXC1, the new player in the cancer sandbox

(2017) Fahed A. Elian et al.   Oncotarget

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation

(2016) Rosa Bacchetta et al.   Annals of the New York Academy of Sciences

Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/β-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia

(2016) Bei Jin et al.   CLINICAL CANCER RESEARCH

Mechanisms of DNA-binding specificity and functional gene regulation by transcription factors

(2016) Ngaio C Smith et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Forkhead box transcription factors in embryonic heart development and congenital heart disease

(2016) Hong Zhu   LIFE SCIENCES

FOXO transcription factors in cancer development and therapy

(2015) Alexandra Coomans de Brachène et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions

(2015) Yongheng Chen et al.   NUCLEIC ACIDS RESEARCH

Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling

(2015) F Kruiswijk et al.   ONCOGENE

Targeting forkhead box transcription factors FOXM1 and FOXO in leukemia (Review)

(2014) HONG ZHU   ONCOLOGY REPORTS

FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801

(2013) Fuminori Yamaguchi et al.   BMC CANCER

DNA-Binding Specificities of Human Transcription Factors

(2013) Arttu Jolma et al.   CELL

Comprehensive prediction in 78 human cell lines reveals rigidity and compactness of transcription factor dimers

(2013) A. Jankowski et al.   GENOME RESEARCH

Widespread evidence of cooperative DNA binding by transcription factors in Drosophila development

(2013) Majid Kazemian et al.   NUCLEIC ACIDS RESEARCH

DNA-binding specificity changes in the evolution of forkhead transcription factors

(2013) S. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple modes of chromatin remodeling by Forkhead box proteins

(2012) Avin S. Lalmansingh et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cancer genetics and genomics of human FOX family genes

(2012) Masuko Katoh et al.   CANCER LETTERS

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

(2012) Christopher E Barbieri et al.   NATURE GENETICS

Two Lysines in the Forkhead Domain of Foxp3 Are Key to T Regulatory Cell Function

(2012) Yujie Liu et al.   PLoS One

Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors

(2012) H. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXM1: From cancer initiation to progression and treatment

(2011) Chuay-Yeng Koo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

FoxM1: A Master Regulator of Tumor Metastasis

(2011) P. Raychaudhuri et al.   CANCER RESEARCH

FoxO6 Integrates Insulin Signaling With Gluconeogenesis in the Liver

(2011) Dae Hyun Kim et al.   DIABETES

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

(2011) Biswajyoti Sahu et al.   EMBO JOURNAL

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers

(2011) A. A. Serandour et al.   GENOME RESEARCH

Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells

(2011) Hozefa S. Bandukwala et al.   IMMUNITY

Evolutionary Origins of Transcription Factor Binding Site Clusters

(2011) Xin He et al.   MOLECULAR BIOLOGY AND EVOLUTION

Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: Insight into its domain swapping and DNA binding

(2011) Yuan-Ping Chu et al.   PROTEIN SCIENCE

Forkhead transcription factors in ovarian function

(2011) Nina Henriette Uhlenhaut et al.   REPRODUCTION

Forkhead transcription factors: key players in health and disease

(2011) Bérénice A. Benayoun et al.   TRENDS IN GENETICS

Structure of the human FOXO4-DBD–DNA complex at 1.9 Å resolution reveals new details of FOXO binding to the DNA

(2010) Evzen Boura et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers

(2010) V. Gotea et al.   GENOME RESEARCH

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence

(2010) D. R. Littler et al.   NUCLEIC ACIDS RESEARCH

High-resolution DNA-binding specificity analysis of yeast transcription factors

(2009) C. Zhu et al.   GENOME RESEARCH

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

Control of Regulatory T Cell Lineage Commitment and Maintenance

(2009) Steven Z. Josefowicz et al.   IMMUNITY

Stable Chromatin Binding Prevents FoxA Acetylation, Preserving FoxA Chromatin Remodeling

(2009) Sarah Kohler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evolution of Fox genes and their role in development and disease

(2009) Sridhar Hannenhalli et al.   NATURE REVIEWS GENETICS

Domain Requirements and Sequence Specificity of DNA Binding for the Forkhead Transcription Factor FOXP3

(2009) Kian Peng Koh et al.   PLoS One

Diversity and Complexity in DNA Recognition by Transcription Factors

(2009) G. Badis et al.   SCIENCE

FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription

(2008) Mathieu Lupien et al.   CELL

Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

(2008) Sarah De Val et al.   CELL

Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53

(2008) Feng Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

(2008) Rupesh H Amin et al.   NATURE IMMUNOLOGY

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

(2008) Hart S Dengler et al.   NATURE IMMUNOLOGY

Structure/function relationships underlying regulation of FOXO transcription factors

(2008) T Obsil et al.   ONCOGENE

FOXO-binding partners: it takes two to tango

(2008) K E van der Vos et al.   ONCOGENE

Activation of FOXO1 by Cdk1 in Cycling Cells and Postmitotic Neurons

(2008) Z. Yuan et al.   SCIENCE

Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification

(2008) Michael M. Brent et al.   STRUCTURE