Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease

Optimized TrkB Agonist Ameliorates Alzheimer’s Disease Pathologies and Improves Cognitive Functions via Inhibiting Delta-Secretase

(2021) Chun Chen et al.   ACS Chemical Neuroscience

CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons

(2020) Eli-Eelika Esvald et al.   JOURNAL OF NEUROSCIENCE

Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer’s disease

(2019) Antoine Leuzy et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies

(2019) Jie Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease

(2019) Zhi-Hao Wang et al.   Cell Reports

Neuro-regeneration Therapeutic for Alzheimer’s Dementia: Perspectives on Neurotrophic Activity

(2019) Miao-Kun Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology

(2019) Kaj Blennow et al.   BRAIN

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer’s disease

(2018) Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer’s disease

(2018) Zhi-Hao Wang et al.   Nature Communications

Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer’s disease

(2017) Zhentao Zhang et al.   Nature Communications

Legumain is activated in macrophages during pancreatitis

(2016) Laura E. Edgington-Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Structure and function of legumain in health and disease

(2016) Elfriede Dall et al.   BIOCHIMIE

Self-amplified BDNF transcription is a regulatory system for synaptic maturation in cultured cortical neurons

(2015) Shingo Nakajima et al.   NEUROCHEMISTRY INTERNATIONAL

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

(2015) Zhentao Zhang et al.   Nature Communications

Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease

(2014) Zhentao Zhang et al.   NATURE MEDICINE

CCAAT-Enhancer Binding Protein-β Expression and Elevation in Alzheimer’s Disease and Microglial Cell Cultures

(2014) Ron Strohmeyer et al.   PLoS One

7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

(2013) Zhentao Zhang et al.   NEUROPSYCHOPHARMACOLOGY

7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, Reverses Memory Deficits and BACE1 Elevation in a Mouse Model of Alzheimer's Disease

(2011) Latha Devi et al.   NEUROPSYCHOPHARMACOLOGY

Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning

(2010) Raul Andero et al.   AMERICAN JOURNAL OF PSYCHIATRY

A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect

(2010) Xia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear

(2010) D. C. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone

(2010) S.-W. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-Derived Neurotrophic Factor Reduces Amyloidogenic Processing through Control of SORLA Gene Expression

(2009) M. Rohe et al.   JOURNAL OF NEUROSCIENCE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

(2008) Ryan G. Soderquist et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

NGF and BDNF signaling control amyloidogenic route and A  production in hippocampal neurons

(2008) C. Matrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA