Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

(2019) Manoela V. Fogaça et al.   Frontiers in Cellular Neuroscience

Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders

(2019) Vikaas S. Sohal et al.   MOLECULAR PSYCHIATRY

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

(2019) Chloe E. Page et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mechanisms of ketamine action as an antidepressant

(2018) P Zanos et al.   MOLECULAR PSYCHIATRY

Region-specific Expression of NMDA Receptor GluN2C Subunit in Parvalbumin-Positive Neurons and Astrocytes: Analysis of GluN2C Expression using a Novel Reporter Model

(2018) Aparna Ravikrishnan et al.   NEUROSCIENCE

Disinhibition of CA1 pyramidal cells by low-dose ketamine and other antagonists with rapid antidepressant efficacy

(2018) Allie J. Widman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders

(2018) Brielle R. Ferguson et al.   Frontiers in Neural Circuits

Infralimbic prefrontal cortex structural and functional connectivity with the limbic forebrain: a combined viral genetic and optogenetic analysis

(2018) Miranda Wood et al.   Brain Structure & Function

Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

(2018) Yan Yang et al.   NATURE

GABAergic inhibition gates excitatory LTP in perirhinal cortex

(2017) Vibhakar C. Kotak et al.   HIPPOCAMPUS

Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine

(2017) Soichiro Ide et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Changes in the Prefrontal Glutamatergic and Parvalbumin Systems of Mice Exposed to Unpredictable Chronic Stress

(2017) Ryan Shepard et al.   MOLECULAR NEUROBIOLOGY

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models

(2016) E. Khlestova et al.   JOURNAL OF NEUROSCIENCE

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

(2016) G M I Chowdhury et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

(2016) Oliver H. Miller et al.   NEUROPHARMACOLOGY

Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders

(2016) Ryan Shepard et al.   NEUROSCIENCE

Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase

(2016) Toshifumi Yamamoto et al.   NEUROSCIENCE LETTERS

What Are We Learning From Early-Phase Clinical Trials With Glutamate Targeting Medications for the Treatment of Major Depressive Disorder

(2016) Gerard Sanacora   JAMA Psychiatry

Stress Effects on Neuronal Structure: Hippocampus, Amygdala and Prefrontal Cortex

(2015) Bruce S McEwen et al.   NEUROPSYCHOPHARMACOLOGY

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

(2015) Manabu Fuchikami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An excitatory synapse hypothesis of depression

(2015) Scott M. Thompson et al.   TRENDS IN NEUROSCIENCES

A blanket of inhibition: functional inferences from dense inhibitory connectivity

(2014) Mahesh M Karnani et al.   CURRENT OPINION IN NEUROBIOLOGY

Targeting of NMDA Receptors in the Treatment of Major Depression

(2014) Yong-Hui Dang et al.   CURRENT PHARMACEUTICAL DESIGN

Metaplastic effects of subanesthetic ketamine on CA1 hippocampal function

(2014) Yukitoshi Izumi et al.   NEUROPHARMACOLOGY

The Role of GluN2A and GluN2B Subunits on the Effects of NMDA Receptor Antagonists in Modeling Schizophrenia and Treating Refractory Depression

(2014) Laura Jiménez-Sánchez et al.   NEUROPSYCHOPHARMACOLOGY

Neuropathological and neuromorphometric abnormalities in bipolar disorder: View from the medial prefrontal cortical network

(2014) Jonathan B. Savitz et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The STAR*D Trial: Revealing the Need for Better Treatments

(2014) Thomas R. Insel et al.   PSYCHIATRIC SERVICES

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function

(2011) Chih-Chieh Wang et al.   NEURON

Synaptic Activity Controls Dendritic Spine Morphology by Modulating eEF2-Dependent BDNF Synthesis

(2010) C. Verpelli et al.   JOURNAL OF NEUROSCIENCE

NMDA Receptor Ablation on Parvalbumin-Positive Interneurons Impairs Hippocampal Synchrony, Spatial Representations, and Working Memory

(2010) Tatiana Korotkova et al.   NEURON

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Mechanisms underlying ketamine-induced synaptic depression in rat hippocampus-medial prefrontal cortex pathway

(2010) H. Kamiyama et al.   NEUROSCIENCE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Acute Psychological Stress Reduces Working Memory-Related Activity in the Dorsolateral Prefrontal Cortex

(2009) Shaozheng Qin et al.   BIOLOGICAL PSYCHIATRY

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

Parvalbumin neurons and gamma rhythms enhance cortical circuit performance

(2009) Vikaas S. Sohal et al.   NATURE

Gamma and Delta Neural Oscillations and Association with Clinical Symptoms under Subanesthetic Ketamine

(2009) L Elliot Hong et al.   NEUROPSYCHOPHARMACOLOGY

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Losing inhibition with ketamine

(2008) Jeremy Seamans   Nature Chemical Biology

Long-term potentiation-like facilitation through GABAA receptor blockade in the mouse dentate gyrus in vivo

(2008) Shogo Matsuyama et al.   NEUROREPORT

N-Methyl d-Aspartate Receptor Antagonists Ketamine and MK-801 Induce Wake-Related Aberrant γ Oscillations in the Rat Neocortex

(2007) Didier Pinault   BIOLOGICAL PSYCHIATRY