Spine dynamics in the brain, mental disorders and artificial neural networks

Structure and function of a neocortical synapse

(2021) Simone Holler et al.   NATURE

Dual-component structural plasticity mediated by αCaMKII-autophosphorylation on basal dendrites of cortical layer 2/3 neurones

(2020) Gillian Seaton et al.   JOURNAL OF NEUROSCIENCE

Activity dependent and independent determinants of synaptic size diversity

(2020) Liran Hazan et al.   JOURNAL OF NEUROSCIENCE

Twenty Years of SynGAP Research: From Synapses to Cognition

(2020) Timothy R. Gamache et al.   JOURNAL OF NEUROSCIENCE

Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking

(2020) Anne L. Collins et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Direct Fit to Nature: An Evolutionary Perspective on Biological and Artificial Neural Networks

(2020) Uri Hasson et al.   NEURON

Elevated PSD-95 Blocks Ion-flux Independent LTD: A Potential New Role for PSD-95 in Synaptic Plasticity

(2020) Kim Dore et al.   NEUROSCIENCE

The unreasonable effectiveness of deep learning in artificial intelligence

(2020) Terrence J. Sejnowski   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes and Microglia: In Sickness and in Health

(2020) Ilia D. Vainchtein et al.   TRENDS IN NEUROSCIENCES

Molecular Mechanisms of Non-ionotropic NMDA Receptor Signaling in Dendritic Spine Shrinkage

(2020) Ivar S. Stein et al.   JOURNAL OF NEUROSCIENCE

Dopamine D2 receptors in discrimination learning and spine enlargement

(2020) Yusuke Iino et al.   NATURE

The transition to compulsion in addiction

(2020) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Backpropagation and the brain

(2020) Timothy P. Lillicrap et al.   NATURE REVIEWS NEUROSCIENCE

Deep Reinforcement Learning and Its Neuroscientific Implications

(2020) Matthew Botvinick et al.   NEURON

Edge of Chaos and Avalanches in Neural Networks with Heavy-Tailed Synaptic Weight Distribution

(2020) Łukasz Kuśmierz et al.   PHYSICAL REVIEW LETTERS

Computational Characteristics of the Striatal Dopamine System Described by Reinforcement Learning With Fast Generalization

(2020) Yoshihisa Fujita et al.   Frontiers in Computational Neuroscience

Signaling models for dopamine-dependent temporal contiguity in striatal synaptic plasticity

(2020) Hidetoshi Urakubo et al.   PLoS Computational Biology

Regulation of actin dynamics in dendritic spines: nanostructure, molecular mobility, and signaling mechanisms

(2020) Shigeo Okabe   MOLECULAR AND CELLULAR NEUROSCIENCE

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

(2020) Courtney K. Walker et al.   NEUROSCIENTIST

Cortical response selectivity derives from strength in numbers of synapses

(2020) Benjamin Scholl et al.   NATURE

Cell-type-specific asynchronous modulation of PKA by dopamine in learning

(2020) Suk Joon Lee et al.   NATURE

Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms

(2019) Robert A. McCutcheon et al.   TRENDS IN NEUROSCIENCES

Theories of Error Back-Propagation in the Brain

(2019) James C.R. Whittington et al.   TRENDS IN COGNITIVE SCIENCES

Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia

(2019) Brandon C. McKinney et al.   NEUROPSYCHOPHARMACOLOGY

Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP

(2019) Takeo Saneyoshi et al.   NEURON

Sleep deprivation by exposure to novel objects increases synapse density and axon-spine interface in the hippocampal CA1 region of adolescent mice

(2019) Giovanna Maria Spano et al.   JOURNAL OF NEUROSCIENCE

The Stability of Glutamatergic Synapses Is Independent of Activity Level, but Predicted by Synapse Size

(2019) Dylan P. Quinn et al.   Frontiers in Cellular Neuroscience

Intrinsic Spine Dynamics Are Critical for Recurrent Network Learning in Models With and Without Autism Spectrum Disorder

(2019) James Humble et al.   Frontiers in Computational Neuroscience

Neuronal and synaptic protein lifetimes

(2019) Laurie D Cohen et al.   CURRENT OPINION IN NEUROBIOLOGY

Believing in dopamine

(2019) Samuel J. Gershman et al.   NATURE REVIEWS NEUROSCIENCE

Learning from Action: Reconsidering Movement Signaling in Midbrain Dopamine Neuron Activity

(2019) Luke T. Coddington et al.   NEURON

Dense connectomic reconstruction in layer 4 of the somatosensory cortex

(2019) Alessandro Motta et al.   SCIENCE

C. elegans neurons have functional dendritic spines

(2019) Andrea Cuentas-Condori et al.   eLife

Cortical dendritic spine development and plasticity: insights from in vivo imaging

(2018) Caitlin E Moyer et al.   CURRENT OPINION IN NEUROBIOLOGY

Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid

(2018) G. Murakami et al.   JOURNAL OF NEUROENDOCRINOLOGY

Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites

(2018) Erik B. Bloss et al.   NATURE NEUROSCIENCE

Dendritic structural plasticity and neuropsychiatric disease

(2018) Marc P. Forrest et al.   NATURE REVIEWS NEUROSCIENCE

Calcineurin knockout mice show a selective loss of small spines

(2018) Hitoshi Okazaki et al.   NEUROSCIENCE LETTERS

Interregional synaptic maps among engram cells underlie memory formation

(2018) Jun-Hyeok Choi et al.   SCIENCE

Synaptic Tenacity or Lack Thereof: Spontaneous Remodeling of Synapses

(2018) Noam E. Ziv et al.   TRENDS IN NEUROSCIENCES

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

(2018) Thomas Pfeiffer et al.   eLife

Inhibitory connectivity defines the realm of excitatory plasticity

(2018) Gianluigi Mongillo et al.   NATURE NEUROSCIENCE

Eligibility Traces and Plasticity on Behavioral Time Scales: Experimental Support of NeoHebbian Three-Factor Learning Rules

(2018) Wulfram Gerstner et al.   Frontiers in Neural Circuits

Deconstructing and Reconstructing the Dichotomy That Is Dopamine Receptor-1– and Dopamine Receptor-2–Expressing Neurons

(2018) Peter W. Kalivas   BIOLOGICAL PSYCHIATRY

The role of drebrin in neurons

(2017) Tomoaki Shirao et al.   JOURNAL OF NEUROCHEMISTRY

CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca 2+ Signals during LTP Induction, but Not Maintenance

(2017) Jui-Yun Chang et al.   NEURON

Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission

(2017) Richard Sando et al.   NEURON

Spine Dynamics: Are They All the Same?

(2017) Kalen P. Berry et al.   NEURON

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release

(2017) Albrecht Sigler et al.   NEURON

Neuroscience-Inspired Artificial Intelligence

(2017) Demis Hassabis et al.   NEURON

Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

(2017) Tara Keck et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Overcoming catastrophic forgetting in neural networks

(2017) James Kirkpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle

(2017) Luisa de Vivo et al.   SCIENCE

Cooperative stochastic binding and unbinding explain synaptic size dynamics and statistics

(2017) Aseel Shomar et al.   PLoS Computational Biology

Dendritic Spine Pathology in Neurodegenerative Diseases

(2016) Jochen Herms et al.   Annual Review of Pathology-Mechanisms of Disease

Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking

(2016) Bruce E. Herring et al.   Annual Review of Physiology

Schizophrenia

(2016) Michael J Owen et al.   LANCET

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

Selective synaptic remodeling of amygdalocortical connections associated with fear memory

(2016) Yang Yang et al.   NATURE NEUROSCIENCE

Integrins in synapse regulation

(2016) Yun Kyung Park et al.   NATURE REVIEWS NEUROSCIENCE

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

(2016) Taku Nagai et al.   NEURON

Excitation-Transcription Coupling in Parvalbumin-Positive Interneurons Employs a Novel CaM Kinase-Dependent Pathway Distinct from Excitatory Neurons

(2016) Samuel M. Cohen et al.   NEURON

Reappraising striatal D1- and D2-neurons in reward and aversion

(2016) Carina Soares-Cunha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Convolutional networks for fast, energy-efficient neuromorphic computing

(2016) Steven K. Esser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homeostatic Plasticity Achieved by Incorporation of Random Fluctuations and Soft-Bounded Hebbian Plasticity in Excitatory Synapses

(2016) Takashi Matsubara et al.   Frontiers in Neural Circuits

Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses

(2016) Roman Dvorkin et al.   PLOS BIOLOGY

Learning Reward Uncertainty in the Basal Ganglia

(2016) John G. Mikhael et al.   PLoS Computational Biology

Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo

(2016) Akira Nagaoka et al.   Scientific Reports

A biomechanical perspective on stress fiber structure and function

(2015) Elena Kassianidou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Saturated Reconstruction of a Volume of Neocortex

(2015) Narayanan Kasthuri et al.   CELL

Predicting the Dynamics of Network Connectivity in the Neocortex

(2015) Y. Loewenstein et al.   JOURNAL OF NEUROSCIENCE

Impermanence of dendritic spines in live adult CA1 hippocampus

(2015) Alessio Attardo et al.   NATURE

Labelling and optical erasure of synaptic memory traces in the motor cortex

(2015) Akiko Hayashi-Takagi et al.   NATURE

Functional organization of excitatory synaptic strength in primary visual cortex

(2015) Lee Cossell et al.   NATURE

A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII

(2015) Karam Kim et al.   NEURON

Distinct Eligibility Traces for LTP and LTD in Cortical Synapses

(2015) Kaiwen He et al.   NEURON

Remodeling and Tenacity of Inhibitory Synapses: Relationships with Network Activity and Neighboring Excitatory Synapses

(2015) Anna Rubinski et al.   PLoS Computational Biology

Network Plasticity as Bayesian Inference

(2015) David Kappel et al.   PLoS Computational Biology

Nanoconnectomic upper bound on the variability of synaptic plasticity

(2015) Thomas M Bartol et al.   eLife

The role of neuronal activity and transmitter release on synapse formation

(2014) Laura C Andreae et al.   CURRENT OPINION IN NEUROBIOLOGY

Spiking Deep Convolutional Neural Networks for Energy-Efficient Object Recognition

(2014) Yongqiang Cao et al.   INTERNATIONAL JOURNAL OF COMPUTER VISION

The Relationship between PSD-95 Clustering and Spine Stability In Vivo

(2014) M. Cane et al.   JOURNAL OF NEUROSCIENCE

Working Memory Contributions to Reinforcement Learning Impairments in Schizophrenia

(2014) Anne G.E. Collins et al.   JOURNAL OF NEUROSCIENCE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey

(2014) M.E. Young et al.   NEUROSCIENCE

Presynaptic and Postsynaptic Scaffolds

(2014) Noam E. Ziv et al.   NEUROSCIENTIST

PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence

(2014) A. Hayashi-Takagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep promotes branch-specific formation of dendritic spines after learning

(2014) G. Yang et al.   SCIENCE

A critical time window for dopamine actions on the structural plasticity of dendritic spines

(2014) S. Yagishita et al.   SCIENCE

Emerging role of CaMKII in neuropsychiatric disease

(2014) A.J. Robison   TRENDS IN NEUROSCIENCES

Dopaminergic basis of salience dysregulation in psychosis

(2014) Toby T. Winton-Brown et al.   TRENDS IN NEUROSCIENCES

Enhanced synapse remodelling as a common phenotype in mouse models of autism

(2014) Masaaki Isshiki et al.   Nature Communications

Synaptic Size Dynamics as an Effectively Stochastic Process

(2014) Adiel Statman et al.   PLoS Computational Biology

Motor Skill Training Induces Coordinated Strengthening and Weakening between Neighboring Synapses

(2013) K. J. Lee et al.   JOURNAL OF NEUROSCIENCE

Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities

(2013) I. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Dendritic Arborization and Spine Dynamics Are Abnormal in the Mouse Model of MECP2 Duplication Syndrome

(2013) M. Jiang et al.   JOURNAL OF NEUROSCIENCE

Altered Structural and Functional Synaptic Plasticity with Motor Skill Learning in a Mouse Model of Fragile X Syndrome

(2013) R. Padmashri et al.   JOURNAL OF NEUROSCIENCE

Mental health: On the spectrum

(2013) David Adam   NATURE

GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling

(2013) Tatsuya Hayama et al.   NATURE NEUROSCIENCE

Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance

(2013) Conor Liston et al.   NATURE NEUROSCIENCE

The Dynamic Synapse

(2013) Daniel Choquet et al.   NEURON

Long-term depression triggers the selective elimination of weakly integrated synapses

(2013) J. S. Wiegert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIα and Calcineurin

(2013) Hajime Fujii et al.   Cell Reports

Interpyramid Spike Transmission Stabilizes the Sparseness of Recurrent Network Activity

(2012) Y. Ikegaya et al.   CEREBRAL CORTEX

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

(2012) Jeremiah Y. Cohen et al.   NATURE

Neuromodulation of Neuronal Circuits: Back to the Future

(2012) Eve Marder   NEURON

Neuroligin-1 Loss Is Associated with Reduced Tenacity of Excitatory Synapses

(2012) Adel Zeidan et al.   PLoS One

Long-term Relationships between Cholinergic Tone, Synchronous Bursting and Synaptic Remodeling

(2012) Maya Kaufman et al.   PLoS One

Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening

(2012) Won Chan Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Striatal Projection Systems by Dopamine

(2011) Charles R. Gerfen et al.   Annual Review of Neuroscience

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

Multiplicative Dynamics Underlie the Emergence of the Log-Normal Distribution of Spine Sizes in the Neocortex In Vivo

(2011) Y. Loewenstein et al.   JOURNAL OF NEUROSCIENCE

Rapid and reversible formation of spine head filopodia in response to muscarinic receptor activation in CA1 pyramidal cells

(2011) Philipp Schätzle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

(2011) Hideji Murakoshi et al.   NATURE

Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo

(2011) C. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A few strong connections: optimizing information retention in neuronal avalanches

(2010) Wei Chen et al.   BMC NEUROSCIENCE

Learning rules and persistence of dendritic spines

(2010) Haruo Kasai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ultrastructural Analysis of Hippocampal Neuropil from the Connectomics Perspective

(2010) Yuriy Mishchenko et al.   NEURON

Myosin IIb Regulates Actin Dynamics during Synaptic Plasticity and Memory Formation

(2010) Christopher S. Rex et al.   NEURON

Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome

(2010) Feng Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII control of spine size and synaptic strength: Role of phosphorylation states and nonenzymatic action

(2010) H. J. Pi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

Structural dynamics of dendritic spines in memory and cognition

(2010) Haruo Kasai et al.   TRENDS IN NEUROSCIENCES

Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage

(2009) Kazumasa Matsumoto-Miyai et al.   CELL

A Simple Rule for Axon Outgrowth and Synaptic Competition Generates Realistic Connection Lengths and Filling Fractions

(2009) Marcus Kaiser et al.   CEREBRAL CORTEX

Characterization of dendritic spines in theDrosophilacentral nervous system

(2009) Florian Leiss et al.   Developmental Neurobiology

Two types of dopamine neuron distinctly convey positive and negative motivational signals

(2009) Masayuki Matsumoto et al.   NATURE

Activation of CaMKII in single dendritic spines during long-term potentiation

(2009) Seok-Jin R. Lee et al.   NATURE

Rapid formation and selective stabilization of synapses for enduring motor memories

(2009) Tonghui Xu et al.   NATURE

Stably maintained dendritic spines are associated with lifelong memories

(2009) Guang Yang et al.   NATURE

The probability of neurotransmitter release: variability and feedback control at single synapses

(2009) Tiago Branco et al.   NATURE REVIEWS NEUROSCIENCE

Rapid Functional Maturation of Nascent Dendritic Spines

(2009) Karen Zito et al.   NEURON

Long-Term Relationships between Synaptic Tenacity, Synaptic Remodeling, and Network Activity

(2009) Amir Minerbi et al.   PLOS BIOLOGY

Principles of Long-Term Dynamics of Dendritic Spines

(2008) N. Yasumatsu et al.   JOURNAL OF NEUROSCIENCE

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines

(2008) Naoki Honkura et al.   NEURON

Rapid enhancement of two-step wiring plasticity by estrogen and NMDA receptor activity

(2008) D. P. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

(2008) J.-i. Tanaka et al.   SCIENCE

Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

(2008) W. Shen et al.   SCIENCE