The transition to compulsion in addiction

Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic afferents to nucleus accumbens modulate depressive-like behavior

(2019) Chen-Jie Shen et al.   NATURE MEDICINE

Goal-Directed and Habitual Control in Smokers

(2019) Maartje Luijten et al.   NICOTINE & TOBACCO RESEARCH

Mu opioid receptors in the medial habenula contribute to naloxone aversion

(2019) L. J. Boulos et al.   NEUROPSYCHOPHARMACOLOGY

Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals

(2019) Yuzheng Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed rewards facilitate habit formation.

(2019) Gonzalo P. Urcelay et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit

(2019) Emily Roltsch Hellard et al.   NEUROPHARMACOLOGY

Time-dependent competition between goal-directed and habitual response preparation

(2019) Robert M. Hardwick et al.   Nature Human Behaviour

A cortical-brainstem circuit predicts and governs compulsive alcohol drinking

(2019) Cody A. Siciliano et al.   SCIENCE

Frontal cortex neuron types categorically encode single decision variables

(2019) Junya Hirokawa et al.   NATURE

Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine

(2019) Nicholas R. Wall et al.   NEURON

Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement

(2019) Gabriel Heymann et al.   NEURON

The Bilateral Prefronto-striatal Pathway Is Necessary for Learning New Goal-Directed Actions

(2018) Genevra Hart et al.   CURRENT BIOLOGY

Intact goal-directed control in treatment-seeking drug users indexed by outcome-devaluation and Pavlovian to instrumental transfer: Critique of habit theory

(2018) Lee Hogarth et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine

(2018) Ritchy Hodebourg et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mesencephalic dopamine neurons interfacing the shell of nucleus accumbens and the dorsolateral striatum in the rat

(2018) Floris G. Wouterlood et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Specializations for reward-guided decision-making in the primate ventral prefrontal cortex

(2018) Elisabeth A. Murray et al.   NATURE REVIEWS NEUROSCIENCE

Nucleus Accumbens Subnuclei Regulate Motivated Behavior via Direct Inhibition and Disinhibition of VTA Dopamine Subpopulations

(2018) Hongbin Yang et al.   NEURON

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

(2018) Tommaso Patriarchi et al.   SCIENCE

A molecular mechanism for choosing alcohol over an alternative reward

(2018) Eric Augier et al.   SCIENCE

Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits

(2018) Rafael Renteria et al.   Nature Communications

Hypersensitivity of Prelimbic Cortex Neurons Contributes to Aggravated Nociceptive Responses in Rats With Experience of Chronic Inflammatory Pain

(2018) Xiao-Cen Fan et al.   Frontiers in Molecular Neuroscience

Stochastic synaptic plasticity underlying compulsion in a model of addiction

(2018) Vincent Pascoli et al.   NATURE

Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement

(2018) Julie Corre et al.   eLife

Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits

(2017) Karina P. Abrahao et al.   NEURON

Evidence for a Long-Lasting Compulsive Alcohol Seeking Phenotype in Rats

(2017) Chiara Giuliano et al.   NEUROPSYCHOPHARMACOLOGY

Punishment of alcohol-reinforced responding in alcohol preferring P rats reveals a bimodal population: Implications for models of compulsive drug seeking

(2017) Nathan J. Marchant et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Trying to make sense of rodents' drug choice behavior

(2017) Serge H. Ahmed   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Behavioral and neural mechanisms underlying habitual and compulsive drug seeking

(2017) Rachel J. Smith et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Blunted Dopamine Transmission in Addiction: Potential Mechanisms and Implications for Behavior

(2017) Pierre Trifilieff et al.   SEMINARS IN NUCLEAR MEDICINE

Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

(2016) Barry J. Everitt et al.   Annual Review of Psychology

Psychology of Habit

(2016) Wendy Wood et al.   Annual Review of Psychology

Transcranial magnetic stimulation of dorsolateral prefrontal cortex reduces cocaine use: A pilot study

(2016) Alberto Terraneo et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A thalamic input to the nucleus accumbens mediates opiate dependence

(2016) Yingjie Zhu et al.   NATURE

Antagonistic negative and positive neurons of the basolateral amygdala

(2016) Joshua Kim et al.   NATURE NEUROSCIENCE

Lateral hypothalamic circuits for feeding and reward

(2016) Garret D Stuber et al.   NATURE NEUROSCIENCE

Synaptic mechanisms underlying persistent cocaine craving

(2016) Marina E. Wolf   NATURE REVIEWS NEUROSCIENCE

Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation

(2016) Christina M. Gremel et al.   NEURON

Lateral Habenula Involvement in Impulsive Cocaine Seeking

(2016) Agustin Zapata et al.   NEUROPSYCHOPHARMACOLOGY

A review of the literature on contingency management in the treatment of substance use disorders, 2009–2014

(2016) Danielle R. Davis et al.   PREVENTIVE MEDICINE

Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior

(2016) Alex B. Kawa et al.   PSYCHOPHARMACOLOGY

Carrots and sticks fail to change behavior in cocaine addiction

(2016) K. D. Ersche et al.   SCIENCE

In search of predictive endophenotypes in addiction: insights from preclinical research

(2015) D. Belin et al.   GENES BRAIN AND BEHAVIOR

The dopamine theory of addiction: 40 years of highs and lows

(2015) David J. Nutt et al.   NATURE REVIEWS NEUROSCIENCE

Post-training cocaine administration facilitates habit learning and requires the infralimbic cortex and dorsolateral striatum

(2015) Neil Schmitzer-Torbert et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Medial Orbitofrontal Cortex Mediates Outcome Retrieval in Partially Observable Task Situations

(2015) Laura A. Bradfield et al.   NEURON

Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction

(2015) Vincent Pascoli et al.   NEURON

Cell-Type Specific Insertion of GluA2-Lacking AMPARs with Cocaine Exposure Leading to Sensitization, Cue-Induced Seeking and Incubation of Craving

(2015) Jean Terrier et al.   NEUROPSYCHOPHARMACOLOGY

Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits

(2015) Jennifer E. Murray et al.   Nature Communications

Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories - indications for novel treatments of addiction

(2014) Barry J. Everitt   EUROPEAN JOURNAL OF NEUROSCIENCE

Disorders of compulsivity: a common bias towards learning habits

(2014) V Voon et al.   MOLECULAR PSYCHIATRY

Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers

(2014) N D Volkow et al.   MOLECULAR PSYCHIATRY

Contrasting forms of cocaine-evoked plasticity control components of relapse

(2014) Vincent Pascoli et al.   NATURE

Behavioral and Neural Substrates of Habit Formation in Rats Intravenously Self-Administering Nicotine

(2014) Kelly J Clemens et al.   NEUROPSYCHOPHARMACOLOGY

Deep brain stimulation for addiction: why the subthalamic nucleus should be favored

(2013) Yann Pelloux et al.   CURRENT OPINION IN NEUROBIOLOGY

Meta-analysis of structural brain abnormalities associated with stimulant drug dependence and neuroimaging of addiction vulnerability and resilience

(2013) Karen D Ersche et al.   CURRENT OPINION IN NEUROBIOLOGY

Negative reinforcement in drug addiction: the darkness within

(2013) George F Koob   CURRENT OPINION IN NEUROBIOLOGY

Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking

(2013) Billy T. Chen et al.   NATURE

Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake

(2013) Taban Seif et al.   NATURE NEUROSCIENCE

A Dual Operator View of Habitual Behavior Reflecting Cortical and Striatal Dynamics

(2013) Kyle S. Smith et al.   NEURON

From the ventral to the dorsal striatum: Devolving views of their roles in drug addiction

(2013) Barry J. Everitt et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Cocaine Disinhibits Dopamine Neurons by Potentiation of GABA Transmission in the Ventral Tegmental Area

(2013) C. Bocklisch et al.   SCIENCE

The Neurobiology of Opiate Motivation

(2013) R. Ting-A-Kee et al.   Cold Spring Harbor Perspectives in Medicine

Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients

(2013) Z Sjoerds et al.   Translational Psychiatry

Associative learning mechanisms underpinning the transition from recreational drug use to addiction

(2012) Lee Hogarth et al.   Annals of the New York Academy of Sciences

Habitual Alcohol Seeking: Time Course and the Contribution of Subregions of the Dorsal Striatum

(2012) Laura H. Corbit et al.   BIOLOGICAL PSYCHIATRY

Differential Roles of the Dorsolateral and Midlateral Striatum in Punished Cocaine Seeking

(2012) S. Jonkman et al.   JOURNAL OF NEUROSCIENCE

Amygdala Central Nucleus Interacts with Dorsolateral Striatum to Regulate the Acquisition of Habits

(2012) N. W. Lingawi et al.   JOURNAL OF NEUROSCIENCE

Input-specific control of reward and aversion in the ventral tegmental area

(2012) Stephan Lammel et al.   NATURE

Double Dissociation of the Dorsomedial and Dorsolateral Striatal Control Over the Acquisition and Performance of Cocaine Seeking

(2012) Jennifer E Murray et al.   NEUROPSYCHOPHARMACOLOGY

Drug Intake is Sufficient, but Conditioning is not Necessary for the Emergence of Compulsive Cocaine Seeking After Extended Self-Administration

(2012) Sietse Jonkman et al.   NEUROPSYCHOPHARMACOLOGY

Reversible online control of habitual behavior by optogenetic perturbation of medial prefrontal cortex

(2012) K. S. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use

(2012) I. Willuhn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compulsive drug use and its neural substrates

(2012) Heidi M.B. Lesscher et al.   REVIEWS IN THE NEUROSCIENCES

Abnormal Brain Structure Implicated in Stimulant Drug Addiction

(2012) K. D. Ersche et al.   SCIENCE

The orbitofrontal cortex, predicted value, and choice

(2011) Bernard W. Balleine et al.   Annals of the New York Academy of Sciences

Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence

(2011) K. D. Ersche et al.   BRAIN

The General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer Are Differentially Mediated by the Nucleus Accumbens Core and Shell

(2011) L. H. Corbit et al.   JOURNAL OF NEUROSCIENCE

Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour

(2011) Vincent Pascoli et al.   NATURE

Synaptic and Morphological Neuroadaptations in the Putamen Associated with Long-Term, Relapsing Alcohol Drinking in Primates

(2011) Verginia C Cuzon Carlson et al.   NEUROPSYCHOPHARMACOLOGY

Neurobiology of the incubation of drug craving

(2011) Charles L. Pickens et al.   TRENDS IN NEUROSCIENCES

Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum

(2010) Sabine Vollstädt-Klein et al.   ADDICTION

Choice and contingency in the development of behavioral autonomy during instrumental conditioning.

(2010) Yutaka Kosaki et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Shift from Goal-Directed to Habitual Cocaine Seeking after Prolonged Experience in Rats

(2010) A. Zapata et al.   JOURNAL OF NEUROSCIENCE

The central amygdala projection to the substantia nigra reflects prediction error information in appetitive conditioning

(2010) H. J. Lee et al.   LEARNING & MEMORY

Cocaine Is Low on the Value Ladder of Rats: Possible Evidence for Resilience to Addiction

(2010) Lauriane Cantin et al.   PLoS One

Effects of cocaine rewards on neural representations of cognitive demand in nonhuman primates

(2010) Robert E. Hampson et al.   PSYCHOPHARMACOLOGY

Transition to Addiction Is Associated with a Persistent Impairment in Synaptic Plasticity

(2010) F. Kasanetz et al.   SCIENCE

Compulsive alcohol drinking in rodents

(2009) Valentina Vengeliene et al.   ADDICTION BIOLOGY

Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc

(2009) Manuel Mameli et al.   NATURE NEUROSCIENCE

The glutamate homeostasis hypothesis of addiction

(2009) Peter W. Kalivas   NATURE REVIEWS NEUROSCIENCE

Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

(2009) Bernard W Balleine et al.   NEUROPSYCHOPHARMACOLOGY

New dimensions in human laboratory models of addiction

(2008) GEORGE F. KOOB   ADDICTION BIOLOGY

The integrative function of the basal ganglia in instrumental conditioning

(2008) Bernard W. Balleine et al.   BEHAVIOURAL BRAIN RESEARCH

Pattern of Intake and Drug Craving Predict the Development of Cocaine Addiction-like Behavior in Rats

(2008) David Belin et al.   BIOLOGICAL PSYCHIATRY

Brain dopamine response in human opioid addiction

(2008) Mark R.C. Daglish et al.   BRITISH JOURNAL OF PSYCHIATRY

Differential Involvement of the Basolateral Amygdala and Mediodorsal Thalamus in Instrumental Action Selection

(2008) S. B. Ostlund et al.   JOURNAL OF NEUROSCIENCE

Cocaine Seeking Habits Depend upon Dopamine-Dependent Serial Connectivity Linking the Ventral with the Dorsal Striatum

(2008) David Belin et al.   NEURON

Neurobiological substrates for the dark side of compulsivity in addiction

(2008) George F. Koob   NEUROPHARMACOLOGY

High Impulsivity Predicts the Switch to Compulsive Cocaine-Taking

(2008) D. Belin et al.   SCIENCE

The Role of Orbitofrontal Cortex in Drug Addiction: A Review of Preclinical Studies

(2007) Geoffrey Schoenbaum et al.   BIOLOGICAL PSYCHIATRY