Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

(2020) Tom G Richardson et al.   BMJ-British Medical Journal

The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population

(2020) Nathalie Chami et al.   PLOS MEDICINE

Factors associated with participation over time in the Avon Longitudinal Study of Parents and Children: a study using linked education and primary care data

(2020) Rosie P Cornish et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Assessing the Causal Role of Body Mass Index on Cardiovascular Health in Young Adults

(2019) Kaitlin H. Wade et al.   CIRCULATION

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

(2019) Amit V. Khera et al.   CELL

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

(2019) Luca A. Lotta et al.   CELL

Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes

(2018) Lise G. Bjerregaard et al.   NEW ENGLAND JOURNAL OF MEDICINE

MC4R Agonists: Structural Overview on Antiobesity Therapeutics

(2018) Juliana Pereira Lopes Gonçalves et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

(2017) Valérie Turcot et al.   NATURE GENETICS

Melanocortin-4 Receptor Gene Mutations in a Group of Turkish Obese Children and Adolescents

(2017) Selma Tunç et al.   Journal of Clinical Research in Pediatric Endocrinology

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

(2017) Tinh-Hai Collet et al.   Molecular Metabolism

Prospective functional classification of all possible missense variants in PPARG

(2016) Amit R Majithia et al.   NATURE GENETICS

The Obesity Epidemic — Understanding the Disease and the Treatment

(2016) Caroline M. Apovian   NEW ENGLAND JOURNAL OF MEDICINE

Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

(2012) A. Fraser et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

(2012) Andy Boyd et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians

(2011) M. S. Thearle et al.   DIABETES

Obesity due to Melanocortin 4 Receptor (MC4R) Deficiency Is Associated with Increased Linear Growth and Final Height, Fasting Hyperinsulinemia, and Incompletely Suppressed Growth Hormone Secretion

(2010) Carlos E. Martinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Changes in Ponderal Index and Body Mass Index across Childhood and Their Associations with Fat Mass and Cardiovascular Risk Factors at Age 15

(2010) Laura D. Howe et al.   PLoS One

Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant

(2008) J. Krakoff et al.   DIABETES

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

(2008) F. Stutzmann et al.   DIABETES

Modulation of Blood Pressure by Central Melanocortinergic Pathways

(2008) Jerry R. Greenfield et al.   NEW ENGLAND JOURNAL OF MEDICINE