p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models

The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity

(2021) Jiadong Liu et al.   NATURE

Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells

(2020) Zhenhua Hu et al.   NATURE CELL BIOLOGY

ATR expands embryonic stem cell fate potential in response to replication stress

(2020) Sina Atashpaz et al.   eLife

Zscan4 binds nucleosomal microsatellite DNA and protects mouse two-cell embryos from DNA damage

(2020) Rajini Srinivasan et al.   Science Advances

Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment

(2020) Mélanie A. Eckersley-Maslin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dppa2 and Dppa4 directly regulate the Dux-driven zygotic transcriptional program

(2019) Mélanie Eckersley-Maslin et al.   GENES & DEVELOPMENT

The Genetics and Epigenetics of Facioscapulohumeral Muscular Dystrophy

(2019) Charis L. Himeda et al.   Annual Review of Genomics and Human Genetics

Comparison of genotoxic versus nongenotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks

(2019) Allison N. Catizone et al.   CELL CYCLE

Control of p53-dependent transcription and enhancer activity by the p53 family member p63

(2019) Gizem Karsli Uzunbas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular recording of mammalian embryogenesis

(2019) Michelle M. Chan et al.   NATURE

Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development

(2019) Zhiyuan Chen et al.   NATURE GENETICS

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

(2019) Alex R.D. Delbridge et al.   Cell Reports

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

(2018) Michelle Percharde et al.   CELL

Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation

(2018) Ximena Ibarra-Soria et al.   NATURE CELL BIOLOGY

An enhanced CRISPR repressor for targeted mammalian gene regulation

(2018) Nan Cher Yeo et al.   NATURE METHODS

NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins

(2018) Amy E Campbell et al.   eLife

A patient-derived iPSC model revealed oxidative stress increases facioscapulohumeral muscular dystrophy-causative DUX4

(2018) Mitsuru Sasaki-Honda et al.   HUMAN MOLECULAR GENETICS

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States

(2018) Jack-Christophe Cossec et al.   Cell Stem Cell

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

A molecular roadmap for the emergence of early-embryonic-like cells in culture

(2017) Diego Rodriguez-Terrones et al.   NATURE GENETICS

DUX-family transcription factors regulate zygotic genome activation in placental mammals

(2017) Alberto De Iaco et al.   NATURE GENETICS

Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

(2017) Peter G Hendrickson et al.   NATURE GENETICS

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

(2017) Sean C. Shadle et al.   PLoS Genetics

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs

(2016) Mélanie A. Eckersley-Maslin et al.   Cell Reports

p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation

(2016) Hanbing He et al.   Stem Cell Reports

Zygotic Genome Activation Triggers Chromosome Damage and Checkpoint Signaling in C. elegans Primordial Germ Cells

(2015) Melina Butuči et al.   DEVELOPMENTAL CELL

Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres

(2015) S. Tutton et al.   EMBO JOURNAL

Hallmarks of pluripotency

(2015) Alejandro De Los Angeles et al.   NATURE

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly

(2015) Takashi Ishiuchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Numb is required to prevent p53-dependent senescence following skeletal muscle injury

(2015) Isabelle Le Roux et al.   Nature Communications

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly

(2015) Takashi Ishiuchi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p53 Suppresses Tetraploid Development in Mice

(2015) Takuro Horii et al.   Scientific Reports

Histone Variant H2A.X Deposition Pattern Serves as a Functional Epigenetic Mark for Distinguishing the Developmental Potentials of iPSCs

(2014) Tao Wu et al.   Cell Stem Cell

Zscan4 Is Regulated by PI3-Kinase and DNA-Damaging Agents and Directly Interacts with the Transcriptional Repressors LSD1 and CtBP2 in Mouse Embryonic Stem Cells

(2014) Michael P. Storm et al.   PLoS One

The p53/miR-34 axis in development and disease

(2014) M. Rokavec et al.   Journal of Molecular Cell Biology

A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair

(2013) Sébastien Britton et al.   JOURNAL OF CELL BIOLOGY

Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells

(2013) Kathy K Niakan et al.   Nature Protocols

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells

(2013) Kadir C. Akdemir et al.   NUCLEIC ACIDS RESEARCH

Poxviruses Deploy Genomic Accordions to Adapt Rapidly against Host Antiviral Defenses

(2012) Nels C. Elde et al.   CELL

Evolution of DUX gene macrosatellites in placental mammals

(2012) Andreas Leidenroth et al.   CHROMOSOMA

Embryonic stem cell potency fluctuates with endogenous retrovirus activity

(2012) Todd S. Macfarlan et al.   NATURE

Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2

(2012) Richard J L F Lemmers et al.   NATURE GENETICS

CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle

(2011) P. Dent et al.   MOLECULAR INTERVENTIONS

FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst

(2010) Y. Yamanaka et al.   DEVELOPMENT

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes

(2010) Mark Wossidlo et al.   EMBO JOURNAL

Zscan4 regulates telomere elongation and genomic stability in ES cells

(2010) Michal Zalzman et al.   NATURE

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

A Unifying Genetic Model for Facioscapulohumeral Muscular Dystrophy

(2010) R. J. L. F. Lemmers et al.   SCIENCE

Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage

(2009) Celine Ziegler-Birling et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation

(2008) Marnie E Blewitt et al.   NATURE GENETICS