DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy

Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells

(2016) Sujatha Jagannathan et al.   HUMAN MOLECULAR GENETICS

Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure

(2016) Maxime Wery et al.   MOLECULAR CELL

Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults

(2016) Takahiko Yasuda et al.   NATURE GENETICS

Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia

(2016) Yuan-Fang Liu et al.   EBioMedicine

Influence of Repressive Histone and DNA Methylation upon D4Z4 Transcription in Non-Myogenic Cells

(2016) Sunny Das et al.   PLoS One

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

(2015) T. Li et al.   EMBO JOURNAL

Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways

(2015) Amanda M. Rickard et al.   HUMAN MOLECULAR GENETICS

A simple method for generating high-resolution maps of genome-wide protein binding

(2015) Peter J Skene et al.   eLife

A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy

(2015) Qing Feng et al.   eLife

TDP‐1, theCaenorhabditis elegansortholog of TDP‐43, limits the accumulation of double‐stranded RNA

(2014) Tassa K Saldi et al.   EMBO JOURNAL

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

(2014) Zizhen Yao et al.   HUMAN MOLECULAR GENETICS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

(2014) Matthias Wirth et al.   NUCLEIC ACIDS RESEARCH

An ancient defense system eliminates unfit cells from developing tissues during cell competition

(2014) S. N. Meyer et al.   SCIENCE

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

(2014) Darko Bosnakovski et al.   Skeletal Muscle

Facioscapulohumeral dystrophy: the path to consensus on pathophysiology

(2014) Rabi Tawil et al.   Skeletal Muscle

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis

(2013) Janet M. Young et al.   PLoS Genetics

Functional muscle impairment in facioscapulohumeral muscular dystrophy is correlated with oxidative stress and mitochondrial dysfunction

(2012) Ahmed Turki et al.   FREE RADICAL BIOLOGY AND MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

(2011) Linda N. Geng et al.   DEVELOPMENTAL CELL

Immunodetection of Human Double Homeobox 4

(2011) Linda N. Geng et al.   HYBRIDOMA

Overexpression of the c-mycOncogene Inhibits Nonsense-mediated RNA Decay in B Lymphocytes

(2011) Ding Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo

(2010) Lindsay M. Wallace et al.   ANNALS OF NEUROLOGY

Male germ cell apoptosis: regulation and biology

(2010) C. Shaha et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Facioscapulohumeral Dystrophy: Incomplete Suppression of a Retrotransposed Gene

(2010) Lauren Snider et al.   PLoS Genetics

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies

(2008) Darko Bosnakovski et al.   EMBO JOURNAL

ConsensusPathDB—a database for integrating human functional interaction networks

(2008) Atanas Kamburov et al.   NUCLEIC ACIDS RESEARCH

Apoptotic signaling by c-MYC

(2008) B Hoffman et al.   ONCOGENE