CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

(2021) Frances V. Hundley et al.   MOLECULAR CELL

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

(2021) Daniel Horn-Ghetko et al.   NATURE

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Structure and dynamics of the ASB9 CUL-RING E3 Ligase

(2020) Ryan J. Lumpkin et al.   Nature Communications

The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases

(2020) Ryan J. Lumpkin et al.   MOLECULAR & CELLULAR PROTEOMICS

NEDD8 and ubiquitin ligation by cullin-RING E3 ligases

(2020) Kheewoong Baek et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection

(2019) Ruth Hüttenhain et al.   Cell Host & Microbe

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

(2019) Shaheen Kabir et al.   eLife

Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism

(2019) Jennifer M. Binning et al.   Cell Host & Microbe

Structural basis of antagonism of human APOBEC3F by HIV-1 Vif

(2019) Yingxia Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Mechanism of parkin activation by phosphorylation

(2018) Véronique Sauvé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of parkin activation by phosphorylation

(2018) Véronique Sauvé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

(2018) Tara EC Condos et al.   EMBO JOURNAL

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

(2017) Atul Kumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

(2017) Katja K. Dove et al.   STRUCTURE

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI

(2017) Lingmin Yuan et al.   Nature Communications

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

(2017) Atul Kumar et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

(2016) Bernhard C. Lechtenberg et al.   NATURE

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

A neutron-diffraction study of the low-cycle fatigue behaviour of an austenitic stainless steel 316

(2015) Adelaide Dubreuil et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Density modification for macromolecular and small molecule phasing

(2015) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION A

New tools for structure refinement inPHENIX

(2015) Paul Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION A

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

(2014) Daniel C. Scott et al.   CELL

Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif

(2014) Yingying Guo et al.   NATURE

Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases

(2013) Jemima C. Thomas et al.   BIOCHEMISTRY

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes

(2013) Ian R Kelsall et al.   EMBO JOURNAL

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

(2013) David M. Duda et al.   STRUCTURE

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

(2013) David J. Stanley et al.   PLoS Pathogens

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

ARIH2 is essential for embryogenesis and its hematopoietic deficiency causes lethal activation of the immune system

(2012) Amy E Lin et al.   NATURE IMMUNOLOGY

The APOBEC3C crystal structure and the interface for HIV-1 Vif binding

(2012) Shingo Kitamura et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Autoregulation of Parkin activity through its ubiquitin-like domain

(2011) Viduth K Chaugule et al.   EMBO JOURNAL

T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction

(2011) Wenyan Zhang et al.   NATURE

Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection

(2011) Stefanie Jäger et al.   NATURE

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL