Cell fate coordinates mechano-osmotic forces in intestinal crypt formation

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

(2021) Carlos Pérez-González et al.   NATURE CELL BIOLOGY

Integration of luminal pressure and signalling in tissue self-organization

(2020) Chii J. Chan et al.   DEVELOPMENT

Curling of epithelial monolayers reveals coupling between active bending and tissue tension

(2020) Jonathan Fouchard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell mechanics of epithelial shells with organoid-like morphologies

(2020) Jan Rozman et al.   Nature Communications

Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis

(2019) Hendrik A. Messal et al.   NATURE

Apical constriction is necessary for crypt formation in small intestinal organoids

(2019) Leonie Hartl et al.   DEVELOPMENTAL BIOLOGY

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Hydraulic control of mammalian embryo size and cell fate

(2019) Chii Jou Chan et al.   NATURE

Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst

(2019) Julien G. Dumortier et al.   SCIENCE

Active cell migration is critical for steady-state epithelial turnover in the gut

(2019) Denis Krndija et al.   SCIENCE

The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells

(2018) Jiao Li et al.   DEVELOPMENTAL CELL

Morphogenesis and Compartmentalization of the Intestinal Crypt

(2018) Kaelyn D. Sumigray et al.   DEVELOPMENTAL CELL

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme

(2018) Alex J. Hughes et al.   DEVELOPMENTAL CELL

Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel

(2018) Li He et al.   NATURE

Blueprint for an intestinal villus: Species-specific assembly required

(2018) Katherine D. Walton et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo.

(2018) Matthew A Odenwald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer

(2018) Maureen Spit et al.   Open Biology

Differential lateral and basal tension drive folding of Drosophila wing discs through two distinct mechanisms

(2018) Liyuan Sui et al.   Nature Communications

BMP signaling controls buckling forces to modulate looping morphogenesis of the gut

(2017) Nandan L. Nerurkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of intestinal surface: an absorbing tale

(2016) Katherine D. Walton et al.   DEVELOPMENT

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium

(2016) Hiroyuki Miyoshi et al.   EMBO JOURNAL

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function

(2015) Christa N. Grant et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bending Gradients: How the Intestinal Stem Cell Gets Its Home

(2015) Amy E. Shyer et al.   CELL

The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells

(2015) Bing Zhao et al.   Nature Communications

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells

(2015) Mélanie Chabaud et al.   Nature Communications

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

MorphoGraphX: A platform for quantifying morphogenesis in 4D

(2015) Pierre Barbier de Reuille et al.   eLife

How to make an intestine

(2014) J. M. Wells et al.   DEVELOPMENT

Actomyosin networks and tissue morphogenesis

(2014) Akankshi Munjal et al.   DEVELOPMENT

Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

(2014) Sviatoslav N. Bagriantsev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Theory of epithelial sheet morphology in three dimensions

(2013) E. Hannezo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Forces Driving Epithelial Spreading in Zebrafish Gastrulation

(2012) M. Behrndt et al.   SCIENCE

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A

(2011) Y. Zhang et al.   BLOOD

Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia

(2011) B. K. Chauhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Lifeact mice for studying F-actin dynamics

(2010) Julia Riedl et al.   NATURE METHODS

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos

(2009) P.-A. Pouille et al.   Science Signaling

Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling

(2008) T. Nishimura et al.   DEVELOPMENT