Effect of Ellagic Acid on Seizure Threshold in Two Acute Seizure Tests in Mice

Neuroprotective Potential of Ellagic Acid: A Critical Review

(2021) Ashutosh Gupta et al.   Advances in Nutrition

Antioxidants Targeting Mitochondrial Oxidative Stress: Promising Neuroprotectants for Epilepsy

(2020) Nan Yang et al.   Oxidative Medicine and Cellular Longevity

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and apoptosis in the brains of male mice

(2019) Mohamed A. El-Missiry et al.   METABOLIC BRAIN DISEASE

Why we urgently need improved epilepsy therapies for adult patients

(2019) Santoshi Billakota et al.   NEUROPHARMACOLOGY

Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review

(2019) Silvana Alfei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis

(2018) Rebeca Busto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ellagic acid in suppressing in vivo and in vitro oxidative stresses

(2018) Alam Zeb   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ellagic acid: Insights into its neuroprotective and cognitive enhancement effects in sporadic Alzheimer's disease

(2018) Abhishek B. Jha et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The antidepressant-like activity of ellagic acid and its effect on hippocampal brain derived neurotrophic factor levels in mouse depression models

(2017) Hatice Asli Bedel et al.   NATURAL PRODUCT RESEARCH

Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer’s disease: an exploration of underlying mechanisms

(2017) Zahra Kiasalari et al.   PSYCHOPHARMACOLOGY

Insights Into Effects of Ellagic Acid on the Nervous System: A Mini Review

(2016) Touqeer Ahmed et al.   CURRENT PHARMACEUTICAL DESIGN

Glutamate Excitotoxicity and Oxidative Stress in Epilepsy: Modulatory Role of Melatonin

(2016) Shruti Vishnoi et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Monoaminergic Mechanisms in Epilepsy May Offer Innovative Therapeutic Opportunity for Monoaminergic Multi-Target Drugs

(2016) Dubravka Svob Strac et al.   Frontiers in Neuroscience

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

(2015) Tao Yuan et al.   ACS Chemical Neuroscience

Fate of Microbial Metabolites of Dietary Polyphenols in Rats: Is the Brain Their Target Destination?

(2015) Mattia Gasperotti et al.   ACS Chemical Neuroscience

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Ellagic acid prevents cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury

(2015) Yaghoob Farbood et al.   LIFE SCIENCES

Ellagic Acid Antiinflammatory and Antiapoptotic Potential Mediate Renoprotection in Cisplatin Nephrotoxic Rats

(2014) Amany M. El-Garhy et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Ellagic Acid Reduces L-type Ca2+ Current and Contractility Through Modulation of NO-GC-cGMP Pathways in Rat Ventricular Myocytes

(2014) Yusuf Olgar et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Method Development and Validation for Pharmacokinetic and Tissue Distributions of Ellagic Acid Using Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS)

(2014) Linlin Yan et al.   MOLECULES

Ellagic Acid Induces Novel and Atypical PKC Isoforms and Promotes Caspase-3 Dependent Apoptosis by Blocking Energy Metabolism

(2014) Sudha Mishra et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice

(2014) Dinesh Dhingra et al.   Pharmacological Reports

Involvement of L-arginine/NO/cGMP/KATP channel pathway in the peripheral antinociceptive actions of ellagic acid in the rat formalin test

(2014) Behnam Ghorbanzadeh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of ellagic acid in the rat formalin test

(2014) Mohammad Taghi Mansouri et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antiepileptic activity of ellagic acid, a naturally occurring polyphenolic compound, in mice

(2014) Dinesh Dhingra et al.   Journal of Functional Foods

Effects of raspberry fruit extracts and ellagic acid on respiratory burst in murine macrophages

(2014) Lina Raudone et al.   Food & Function

Punicalagin and Ellagic Acid Demonstrate Antimutagenic Activity and Inhibition of Benzo[a]pyrene Induced DNA Adducts

(2014) Maryam Zahin et al.   Biomed Research International

Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain

(2013) Mohammad Taghi Mansouri et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

Ellagic acid attenuates bleomycin and cyclophosphamide-induced pulmonary toxicity in Wistar rats

(2013) Saba et al.   FOOD AND CHEMICAL TOXICOLOGY

Pomegranate Polyphenols and Extract Inhibit Nuclear Factor of Activated T-Cell Activity and Microglial Activation In Vitro and in a Transgenic Mouse Model of Alzheimer Disease

(2013) Lalida Rojanathammanee et al.   JOURNAL OF NUTRITION

Ellagic Acid and Derivatives fromCochlospermum angolensisWelw. Extracts: HPLC-DAD-ESI/MSnProfiling, Quantification andIn VitroAnti-depressant, Anti-cholinesterase and Anti-oxidant Activities

(2013) Federico Ferreres et al.   PHYTOCHEMICAL ANALYSIS

Evaluation of the effects of ellagic acid (EA) on 7,12-dimethylbenz(α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo

(2013) Maria Rosaria Grossi et al.   TOXICOLOGY LETTERS

Nitric Oxide, Epileptic Seizures, and Action of Antiepileptic Drugs

(2012) Monika Banach et al.   CNS & Neurological Disorders-Drug Targets

Evidence for the involvement of the monoaminergic system, but not the opioid system in the antidepressant-like activity of ellagic acid in mice

(2012) Chandrashekaran Girish et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adverse effects of antiepileptic drugs

(2012) Piero Perucca et al.   LANCET NEUROLOGY

UV and MS Identification of Urolithins and Nasutins, the Bioavailable Metabolites of Ellagitannins and Ellagic Acid in Different Mammals

(2011) Rocío González-Barrio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cytokines and epilepsy

(2011) Gang Li et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Ellagic acid protects hepatocytes from damage by inhibiting mitochondrial production of reactive oxygen species

(2009) Jung Me Hwang et al.   BIOMEDICINE & PHARMACOTHERAPY

Preclinical assessment of proconvulsant drug activity and its relevance for predicting adverse events in humans

(2009) Wolfgang Löscher   EUROPEAN JOURNAL OF PHARMACOLOGY

High-Throughput Cell-Based Screen for Chemicals That Inhibit Infection by Simian Virus 40 and Human Polyomaviruses

(2009) E. C. Goodwin et al.   JOURNAL OF VIROLOGY

The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs

(2009) M.M. Castel-Branco et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Safety assessment of pomegranate fruit extract: Acute and subchronic toxicity studies

(2008) Chintan Patel et al.   FOOD AND CHEMICAL TOXICOLOGY