Targeting of lactate dehydrogenase C dysregulates the cell cycle and sensitizes breast cancer cells to DNA damage response targeted therapy

Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy

(2020) Remy Thomas et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition

(2020) Mónica Álvarez-Fernández et al.   CANCER CELL

Wee1 Inhibition Enhances the Anti-Tumor Effects of Capecitabine in Preclinical Models of Triple-Negative Breast Cancer

(2020) Todd M. Pitts et al.   Cancers

Targeting lactate dehydrogenase A ( LDHA ) exerts antileukemic effects on T‐cell acute lymphoblastic leukemia

(2020) Haizhi Yu et al.   Cancer Communications

Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment

(2020) Andrea Balboni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cancer/testis antigen LDHC promotes proliferation and metastasis by activating the PI3K/Akt/GSK-3β-signaling pathway and the in lung adenocarcinoma

(2020) Liangyuan Chen et al.   EXPERIMENTAL CELL RESEARCH

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer

(2019) Ghaneya Al-Khadairi et al.   Journal of Translational Medicine

Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics

(2019) Xiaofang Zeng et al.   Cell Death & Disease

Lactate Dehydrogenases as Metabolic Links between Tumor and Stroma in the Tumor Microenvironment

(2019) Deepshikha Mishra et al.   Cancers

Defining and Modulating ‘BRCAness’

(2019) Andrea K. Byrum et al.   TRENDS IN CELL BIOLOGY

A systematic review of the international prevalence of BRCA mutation in breast cancer

(2019) Nigel Armstrong et al.   Clinical Epidemiology

Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition

(2019) Cody W. Lewis et al.   CANCER RESEARCH

Diagnostic and prognostic value of the cancer-testis antigen lactate dehydrogenase C4 in breast cancer

(2019) Zhaolei Cui et al.   CLINICA CHIMICA ACTA

Neuropilin-1 promotes the oncogenic Tenascin-C/integrin β3 pathway and modulates chemoresistance in breast cancer cells

(2018) Adviti Naik et al.   BMC CANCER

Aurora A kinase activity is required to maintain an active spindle assembly checkpoint during prometaphase

(2018) Thibault Courtheoux et al.   JOURNAL OF CELL SCIENCE

New therapeutic strategies to treat human cancers expressing mutant p53 proteins

(2018) Giovanni Blandino et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The functional diversity of Aurora kinases: a comprehensive review

(2018) Estelle Willems et al.   Cell Division

Mutant p53 as a guardian of the cancer cell

(2018) Fiamma Mantovani et al.   CELL DEATH AND DIFFERENTIATION

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

(2018) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

Expression of lactate dehydrogenase C correlates with poor prognosis in renal cell carcinoma

(2017) Yibo Hua et al.   TUMOR BIOLOGY

BCIP: a gene-centered platform for identifying potential regulatory genes in breast cancer

(2017) Jiaqi Wu et al.   Scientific Reports

Neuropilin-1 Associated Molecules in the Blood Distinguish Poor Prognosis Breast Cancer: A Cross-Sectional Study

(2017) Adviti Naik et al.   Scientific Reports

Molecular Classification of Triple-Negative Breast Cancer

(2016) Sung Gwe Ahn et al.   Journal of Breast Cancer

Expression of lactate dehydrogenase C in MDA-MB-231 cells and its role in tumor invasion and migration

(2016) LINGYING KONG et al.   Molecular Medicine Reports

Safety and activity of alisertib, an investigational aurora kinase A inhibitor, in patients with breast cancer, small-cell lung cancer, non-small-cell lung cancer, head and neck squamous-cell carcinoma, and gastro-oesophageal adenocarcinoma: a five-arm phase 2 study

(2015) Bohuslav Melichar et al.   LANCET ONCOLOGY

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

Oncogenic cancer/testis antigens: prime candidates for immunotherapy

(2015) Morten F. Gjerstorff et al.   Oncotarget

Intrinsic Subtypes from the PAM50 Gene Expression Assay in a Population-Based Breast Cancer Survivor Cohort: Prognostication of Short- and Long-term Outcomes

(2014) B. J. Caan et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Combined Inhibition of Wee1 and PARP1/2 for Radiosensitization in Pancreatic Cancer

(2014) D. Karnak et al.   CLINICAL CANCER RESEARCH

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1

(2014) Monika Raab et al.   Molecular Oncology

BRCAness: a deeper insight into basal-like breast tumors

(2013) S. De Summa et al.   ANNALS OF ONCOLOGY

Mitosis and apoptosis: how is the balance set?

(2013) Caroline H Topham et al.   CURRENT OPINION IN CELL BIOLOGY

Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes

(2013) Brian D Lehmann et al.   JOURNAL OF PATHOLOGY

Sirtuins in stress response: guardians of the genome

(2013) L Bosch-Presegué et al.   ONCOGENE

Chromosomal instability and cancer: a complex relationship with therapeutic potential

(2012) Samuel F. Bakhoum et al.   JOURNAL OF CLINICAL INVESTIGATION

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

(2012) Sohrab P. Shah et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

(2012) Wanjuan Yang et al.   NUCLEIC ACIDS RESEARCH

Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination

(2012) M Krajewska et al.   ONCOGENE

Oxamic acid analogues as LDH-C4-specific competitive inhibitors

(2011) Lorena Rodríguez-Páez et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins

(2011) V. Liberal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Is the Difference Between Triple-Negative and Basal Breast Cancers?

(2010) Melanie D. Seal et al.   CANCER JOURNAL

LDHC: The Ultimate Testis-Specific Gene

(2010) E. Goldberg et al.   JOURNAL OF ANDROLOGY

Mutant p53 mediates survival of breast cancer cells

(2009) L Y Lim et al.   BRITISH JOURNAL OF CANCER

High Frequency of TP53 Mutation in BRCA1 and Sporadic Basal-like Carcinomas but not in BRCA1 Luminal Breast Tumors

(2009) E. Manie et al.   CANCER RESEARCH

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility1

(2008) Fanny Odet et al.   BIOLOGY OF REPRODUCTION

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Cyclin-Dependent Kinase-Associated Proteins Cks1 and Cks2 Are Essential during Early Embryogenesis and for Cell Cycle Progression in Somatic Cells

(2008) H.-S. Martinsson-Ahlzen et al.   MOLECULAR AND CELLULAR BIOLOGY

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE