Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

PARPs and ADP-ribosylation in RNA biology: from RNA expression and processing to protein translation and proteostasis

(2020) Dae-Seok Kim et al.   GENES & DEVELOPMENT

Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family

(2020) Michael S. Cohen   GENES & DEVELOPMENT

Nuclear PARPs and genome integrity

(2020) Kameron Azarm et al.   GENES & DEVELOPMENT

PARP and PARG inhibitors in cancer treatment

(2020) Dea Slade   GENES & DEVELOPMENT

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

(2020) Marcin J. Suskiewicz et al.   NATURE

Genetic screens in isogenic mammalian cell lines without single cell cloning

(2020) Peter C. DeWeirdt et al.   Nature Communications

PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation

(2020) Zoltán G. Páhi et al.   Cancers

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

(2020) Hana Hanzlikova et al.   Nature Communications

Poly(ADP-ribose) glycohydrolase inhibition sequesters NAD+ to potentiate the metabolic lethality of alkylating chemotherapy in IDH mutant tumor cells

(2020) Hiroaki Nagashima et al.   Cancer Discovery

Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin

(2020) Silvija Bilokapic et al.   NATURE

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

(2020) Song My Hoang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping Physiological ADP-Ribosylation Using Activated Ion Electron Transfer Dissociation

(2020) Sara C. Buch-Larsen et al.   Cell Reports

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors

(2019) Nisha Pillay et al.   CANCER CELL

Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies

(2019) Shih-Hsun Chen et al.   Science Advances

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

(2019) Jerry H. Houl et al.   Nature Communications

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

(2018) Ewa Gogola et al.   CANCER CELL

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

Acetylation blocks DNA damage–induced chromatin ADP-ribosylation

(2018) Glen Liszczak et al.   Nature Chemical Biology

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Serine is the major residue for ADP-ribosylation upon DNA damage

(2018) Luca Palazzo et al.   eLife

Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome

(2018) Shereen G. Ghosh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Systems-wide Analysis of Serine ADP-Ribosylation Reveals Widespread Occurrence and Site-Specific Overlap with Phosphorylation

(2018) Sara C. Larsen et al.   Cell Reports

Interplay of Histone Marks with Serine ADP-Ribosylation

(2018) Edward Bartlett et al.   Cell Reports

Bi-allelic ADPRHL2 Mutations Cause Neurodegeneration with Developmental Delay, Ataxia, and Axonal Neuropathy

(2018) Katharina Danhauser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ADP-ribosylation: new facets of an ancient modification

(2017) Luca Palazzo et al.   FEBS Journal

PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes

(2017) Rebecca Gupte et al.   GENES & DEVELOPMENT

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

The role of poly ADP-ribosylation in the first wave of DNA damage response

(2017) Chao Liu et al.   NUCLEIC ACIDS RESEARCH

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase

(2017) Jeannette Abplanalp et al.   Nature Communications

Serine ADP-ribosylation reversal by the hydrolase ARH3

(2017) Pietro Fontana et al.   eLife

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib

(2016) Dominic I. James et al.   ACS Chemical Biology

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

(2016) Martijn S. Luijsterburg et al.   MOLECULAR CELL

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

(2016) Ian Gibbs-Seymour et al.   MOLECULAR CELL

Serine is a new target residue for endogenous ADP-ribosylation on histones

(2016) Orsolya Leidecker et al.   Nature Chemical Biology

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

Lateral Thinking: How Histone Modifications Regulate Gene Expression

(2016) Moyra Lawrence et al.   TRENDS IN GENETICS

Readers of poly(ADP-ribose): designed to be fit for purpose

(2015) Federico Teloni et al.   NUCLEIC ACIDS RESEARCH

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Poly(ADP-Ribosyl) Glycohydrolase Prevents the Accumulation of Unusual Replication Structures during Unperturbed S Phase

(2014) Arnab Ray Chaudhuri et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantification of Cellular Poly(ADP-ribosyl)ation by Stable Isotope Dilution Mass Spectrometry Reveals Tissue- and Drug-Dependent Stress Response Dynamics

(2013) Rita Martello et al.   ACS Chemical Biology

Improved workflows for high throughput library preparation using the transposome-based nextera system

(2013) Sarah Lamble et al.   BMC BIOTECHNOLOGY

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease

(2013) Reza Sharifi et al.   EMBO JOURNAL

ADP-ribosyl-acceptor hydrolase 3 regulates poly (ADP-ribose) degradation and cell death during oxidative stress

(2013) M. Mashimo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities

(2013) Eva Barkauskaite et al.   Nature Communications

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Herpes Simplex Virus 1 Infection Activates Poly(ADP-Ribose) Polymerase and Triggers the Degradation of Poly(ADP-Ribose) Glycohydrolase

(2012) S. L. Grady et al.   JOURNAL OF VIROLOGY

Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase

(2012) Mark S. Dunstan et al.   Nature Communications

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

(2011) Dea Slade et al.   NATURE

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE