Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT

Integrin-linked kinase tunes cell-cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1

(2021) Ayse Nihan Kilinc et al.   MOLECULAR BIOLOGY OF THE CELL

Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer

(2020) Tian-Fu Li et al.   Cancer Cell International

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

Traction forces at the cytokinetic ring regulate cell division and polyploidy in the migrating zebrafish epicardium

(2019) Marina Uroz et al.   NATURE MATERIALS

Mechanochemical Signaling of the Extracellular Matrix in Epithelial-Mesenchymal Transition

(2019) Lewis E. Scott et al.   Frontiers in Cell and Developmental Biology

Proteomics Reveals Rictor as a Non-Canonical TGFB Signaling Target During Aneurysm Progression in Marfan Mice

(2018) Sarah J Parker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail

(2018) Allison K. Simi et al.   CANCER RESEARCH

Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells

(2018) Ryota Kawahara et al.   CANCER SCIENCE

Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis

(2018) Maria Kalli et al.   Frontiers in Oncology

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

(2018) Murugan Kalimutho et al.   EMBO Molecular Medicine

Integrin signaling potentiates transforming growth factor-beta 1 (TGF-β1) dependent down-regulation of E-Cadherin expression – Important implications for epithelial to mesenchymal transition (EMT) in renal cell carcinoma

(2017) B. Feldkoren et al.   EXPERIMENTAL CELL RESEARCH

Tissue Force Programs Cell Fate and Tumor Aggression

(2017) Jason J. Northey et al.   Cancer Discovery

Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin

(2017) Yi-Chun Yeh et al.   Scientific Reports

Anillin Phosphorylation Controls Timely Membrane Association and Successful Cytokinesis

(2017) Hyunjung Kim et al.   PLoS Genetics

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Stiffness-dependent motility and proliferation uncoupled by deletion of CD44

(2017) Ziba Razinia et al.   Scientific Reports

Essential role for a novel population of binucleated mammary epithelial cells in lactation

(2016) Anne C. Rios et al.   Nature Communications

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Aneuploidy and chromosomal instability in cancer: a jackpot to chaos

(2015) Maybelline Giam et al.   Cell Division

Matrix compliance and the regulation of cytokinesis

(2015) S. Sambandamoorthy et al.   Biology Open

New mechanistic insights of integrin β1 in breast cancer bone colonization

(2015) Laure Thibaudeau et al.   Oncotarget

Cytokinetic Abscission: Molecular Mechanisms and Temporal Control

(2014) Beata Mierzwa et al.   DEVELOPMENTAL CELL

A conserved role for Snail as a potentiator of active transcription

(2014) M. Rembold et al.   GENES & DEVELOPMENT

Kinesin Family Deregulation Coordinated by Bromodomain Protein ANCCA and Histone Methyltransferase MLL for Breast Cancer Cell Growth, Survival, and Tamoxifen Resistance

(2014) June X. Zou et al.   MOLECULAR CANCER RESEARCH

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Macroscopic Stiffness of Breast Tumors Predicts Metastasis

(2014) Joseph Fenner et al.   Scientific Reports

Anillin-dependent organization of septin filaments promotes intercellular bridge elongation and Chmp4B targeting to the abscission site

(2014) M. J. Renshaw et al.   Open Biology

Septin functions in organ system physiology and pathology

(2013) Lee Dolat et al.   BIOLOGICAL CHEMISTRY

ESCRT-III Assembly and Cytokinetic Abscission Are Induced by Tension Release in the Intercellular Bridge

(2013) J. Lafaurie-Janvore et al.   SCIENCE

Knowing when to cut and run: mechanisms that control cytokinetic abscission

(2013) Monica Agromayor et al.   TRENDS IN CELL BIOLOGY

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial–mesenchymal transition

(2012) KangAe Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Tumor Susceptibility Gene 101 (TSG101) Is a Novel Binding-Partner for the Class II Rab11-FIPs

(2012) Conor P. Horgan et al.   PLoS One

ESCRT-III Governs the Aurora B-Mediated Abscission Checkpoint Through CHMP4C

(2012) J. G. Carlton et al.   SCIENCE

Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β

(2011) Anna Bianchi et al.   CELL CYCLE

Identification and Characterization of a Novel Integrin-Linked Kinase Inhibitor

(2011) Su-Lin Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Citron kinase controls abscission through RhoA and anillin

(2011) Marta Gai et al.   MOLECULAR BIOLOGY OF THE CELL

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY