miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes

Modulation of miR-34a/SIRT1 signaling protects cochlear hair cells against oxidative stress and delays age-related hearing loss through coordinated regulation of mitophagy and mitochondrial biogenesis

(2019) Hao Xiong et al.   NEUROBIOLOGY OF AGING

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

(2019) Alessia Indrieri et al.   EMBO Molecular Medicine

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila

(2019) Simonetta Andreazza et al.   Nature Communications

Identification of an ATP-sensitive potassium channel in mitochondria

(2019) Angela Paggio et al.   NATURE

Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice

(2019) Peng Chen et al.   Neurotherapeutics

2, 2′, 4, 4′-tetrabromodiphenyl ether (BDE-47) induces mitochondrial dysfunction and related liver injury via eliciting miR-34a-5p-mediated mitophagy impairment

(2019) Feng Chen et al.   ENVIRONMENTAL POLLUTION

lncRNA C2dat1 Promotes Cell Proliferation, Migration, and Invasion by Targeting miR-34a-5p in Osteosarcoma Cells

(2018) Daofu Jia et al.   ONCOLOGY RESEARCH

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

(2018) Mengfan Pu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MicroRNA-410 is involved in mitophagy after cardiac ischemia/reperfusion injury by targeting high-mobility group box 1 protein

(2017) Fan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Activation of miR-34a impairs autophagic flux and promotes cochlear cell death via repressing ATG9A: implications for age-related hearing loss

(2017) Jiaqi Pang et al.   Cell Death & Disease

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

MicroRNA-21 Lowers Blood Pressure in Spontaneous Hypertensive Rats by Upregulating Mitochondrial TranslationClinical Perspective

(2016) Huaping Li et al.   CIRCULATION

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

(2016) Jaekwang Kim et al.   Molecular Neurodegeneration

Deciphering the Molecular Signals of PINK1/Parkin Mitophagy

(2016) Thanh N. Nguyen et al.   TRENDS IN CELL BIOLOGY

BECN1s, a short splice variant of BECN1, functions in mitophagy

(2015) Bing Cheng et al.   Autophagy

Dynamic tubulation of mitochondria drives mitochondrial network formation

(2015) Chong Wang et al.   CELL RESEARCH

The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

(2015) Feng Gao et al.   HUMAN MOLECULAR GENETICS

MiR-34a regulates blood–brain barrier permeability and mitochondrial function by targeting cytochrome c

(2015) Mimi Bukeirat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1

(2015) Kun Wang et al.   Nature Communications

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

MicroRNA-137 Is a Novel Hypoxia-responsive MicroRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX

(2014) Wen Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer

(2014) J Gao et al.   ONCOGENE

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

(2013) I. Barde et al.   SCIENCE

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes

(2011) X.-Y. Bai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

(2011) Lisa Woodbine et al.   NUCLEIC ACIDS RESEARCH

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

(2010) B Li et al.   CELL DEATH AND DIFFERENTIATION

Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy

(2010) Dong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH