Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

(2019) Rajbir Singh et al.   Nature Communications

Evidence-based severity assessment: Impact of repeated versus single open-field testing on welfare in C57BL/6J mice

(2018) Carina Bodden et al.   BEHAVIOURAL BRAIN RESEARCH

d -galactose induces premature senescence of lens epithelial cells by disturbing autophagy flux and mitochondrial functions

(2018) Yao Xu et al.   TOXICOLOGY LETTERS

Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in d-galactose-induced aging mice

(2018) Hong Zhou et al.   RSC Advances

Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose

(2018) Peng Chen et al.   Scientific Reports

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

(2018) Justin M. Long et al.   MOLECULAR PSYCHIATRY

Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells

(2017) Kwang-Youn Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain

(2017) Jie Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics

(2017) Xianjuan Kou et al.   JOURNAL OF APPLIED PHYSIOLOGY

Laquinimod has no effects on brain volume or cellular CNS composition in the F1 3xTg-AD/C3H mouse model of Alzheimer's disease

(2017) Rehana Z. Hussain et al.   JOURNAL OF NEUROIMMUNOLOGY

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Administrations of human adult ischemia-tolerant mesenchymal stem cells and factors reduce amyloid beta pathology in a mouse model of Alzheimer's disease

(2017) Taoufiq Harach et al.   NEUROBIOLOGY OF AGING

A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages

(2017) Saima Rathore et al.   NEUROIMAGE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

SIRT6: Novel Mechanisms and Links to Aging and Disease

(2017) Luisa Tasselli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Apigenin exhibits protective effects in a mouse model of d-galactose-induced aging via activating the Nrf2 pathway

(2017) Ying Sang et al.   Food & Function

MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background

(2016) Zhimin Ye et al.   CANCER LETTERS

Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway

(2016) Jin Gao et al.   METABOLIC BRAIN DISEASE

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms

(2016) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

(2016) Jessica H. Hall et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Stem Cell-Derived Exosomes, Autophagy, Extracellular Matrix Turnover, and miRNAs in Cardiac Regeneration during Stem Cell Therapy

(2016) Priyanka Prathipati et al.   Stem Cell Reviews and Reports

Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway

(2016) Xianjuan Kou et al.   Oncotarget

Stem Cell-Derived Exosomes, Autophagy, Extracellular Matrix Turnover, and miRNAs in Cardiac Regeneration during Stem Cell Therapy

(2016) Priyanka Prathipati et al.   Stem Cell Reviews and Reports

P7C3 Attenuates the Scopolamine-Induced Memory Impairments in C57BL/6J Mice

(2015) Bo Jiang et al.   NEUROCHEMICAL RESEARCH

A river runs through it: how autophagy, senescence, and phagocytosis could be linked to phospholipase D by Wnt signaling

(2014) Julian Gomez-Cambronero et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects

(2013) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients

(2012) Justin M. Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs as targets for dietary and pharmacological inhibitors of mutagenesis and carcinogenesis

(2012) Alberto Izzotti et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Ganoderma atrum polysaccharide attenuates oxidative stress induced by d-galactose in mouse brain

(2011) Wen-Juan Li et al.   LIFE SCIENCES

MicroRNAs as mediators and therapeutic targets in chronic kidney disease

(2011) Johan M. Lorenzen et al.   Nature Reviews Nephrology

SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2

(2010) Barrie Peck et al.   MOLECULAR CANCER THERAPEUTICS

SIRT1: Regulation of longevity via autophagy

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA