The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila

Insulin-like growth factor 1 signaling in motor neuron and polyglutamine diseases: From molecular pathogenesis to therapeutic perspectives

(2020) Maria Pennuto et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Identifying Therapeutic Targets for Spinocerebellar Ataxia Type 3/Machado–Joseph Disease through Integration of Pathological Biomarkers and Therapeutic Strategies

(2020) Yu-Shuan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

(2020) Paula García-Huerta et al.   ACTA NEUROPATHOLOGICA

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

(2020) Anna Niewiadomska-Cimicka et al.   Frontiers in Neuroscience

Compromised IGF signaling causes caspase-6 activation in Huntington disease

(2020) Niels Henning Skotte et al.   EXPERIMENTAL NEUROLOGY

The Expanding Clinical Universe of Polyglutamine Disease

(2019) Shanshan Huang et al.   NEUROSCIENTIST

Insulin and Autophagy in Neurodegeneration

(2019) Natália Prudente de Mello et al.   Frontiers in Neuroscience

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

(2019) Hirokazu Ohata et al.   Cell Reports

From Pathogenesis to Novel Therapeutics for Spinocerebellar Ataxia Type 3: Evading Potholes on the Way to Translation

(2019) Jorge Diogo Da Silva et al.   Neurotherapeutics

Pathogenesis of SCA3 and implications for other polyglutamine diseases

(2019) Hayley S. McLoughlin et al.   NEUROBIOLOGY OF DISEASE

Tissue-Specific Upregulation of Drosophila Insulin Receptor (InR) Mitigates Poly(Q)-Mediated Neurotoxicity by Restoration of Cellular Transcription Machinery

(2018) Kritika Raj et al.   MOLECULAR NEUROBIOLOGY

Roles of the insulin signaling pathway in insect development and organ growth

(2018) Xianyu Lin et al.   PEPTIDES

Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies

(2018) Chunchen Xiang et al.   Frontiers in Molecular Neuroscience

Polyglutamine Repeats in Neurodegenerative Diseases

(2018) Andrew P. Lieberman et al.   Annual Review of Pathology-Mechanisms of Disease

Conserved insulin signaling in the regulation of oocyte growth, development, and maturation

(2017) Debabrata Das et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Polyglutamine spinocerebellar ataxias — from genes to potential treatments

(2017) Henry L. Paulson et al.   NATURE REVIEWS NEUROSCIENCE

Deregulation of autophagy in postmortem brains of Machado-Joseph disease patients

(2017) Annie Sittler et al.   NEUROPATHOLOGY

Essential Amino Acids Improve Insulin Activation of Akt/mTOR Signaling in Soleus Muscle of Aged Rats

(2017) V. Flati et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3β-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1)

(2016) Ivelisse Sánchez et al.   HUMAN MOLECULAR GENETICS

Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status

(2016) Klaus Juergen Schmitz et al.   World Journal of Surgical Oncology

ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation

(2016) Tina Zimmermann et al.   Stem Cell Reports

Insulin/IGF signaling and its regulation in Drosophila

(2015) Dick R. Nässel et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The Transgenic RNAi Project at Harvard Medical School: Resources and Validation

(2015) L. A. Perkins et al.   GENETICS

The S6K protein family in health and disease

(2015) Mariana R. Tavares et al.   LIFE SCIENCES

Acetylation site specificities of lysine deacetylase inhibitors in human cells

(2015) Christian Schölz et al.   NATURE BIOTECHNOLOGY

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

The expanding role for chromatin and transcription in polyglutamine disease

(2014) Ryan D Mohan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Evaluation of acridine orange, LysoTracker Red, and quinacrine as fluorescent probes for long-term tracking of acidic vesicles

(2014) Agnieszka Pierzyńska-Mach et al.   CYTOMETRY PART A

Insulin resistance, neuroinflammation, and Alzheimer’s disease

(2014) Dema Najem et al.   REVIEWS IN THE NEUROSCIENCES

Sirtuin 1 activator SRT2104 protects Huntington's disease mice

(2014) Mali Jiang et al.   Annals of Clinical and Translational Neurology

Drosophila Myc, a novel modifier suppresses the poly(Q) toxicity by modulating the level of CREB binding protein and histone acetylation

(2013) M. Dhruba Singh et al.   NEUROBIOLOGY OF DISEASE

Insulin signaling regulates neurite growth during metamorphic neuronal remodeling

(2013) T. Gu et al.   Biology Open

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction

(2013) Kavitha Kannan et al.   Frontiers in Physiology

Polyglutamine neurodegeneration: expanded glutamines enhance native functions

(2012) Harry T Orr   CURRENT OPINION IN GENETICS & DEVELOPMENT

Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells

(2012) Therese M. Roth et al.   MOLECULAR BIOLOGY OF THE CELL

The localisation of PtdIns3P in Drosophila fat responds to nutrients but not insulin: a role for Class III but not Class II phosphoinositide 3-kinases

(2011) Katie V. Powis et al.   CELLULAR SIGNALLING

Protein aggregates in Huntington's disease

(2011) Montserrat Arrasate et al.   EXPERIMENTAL NEUROLOGY

Huntingtin Aggregation Kinetics and Their Pathological Role in a Drosophila Huntington’s Disease Model

(2011) Kurt R. Weiss et al.   GENETICS

Protein interacting with C kinase (PICK1) is a suppressor of spinocerebellar ataxia 3-associated neurodegeneration in Drosophila

(2011) Leeanne McGurk et al.   HUMAN MOLECULAR GENETICS

Activation of the cardiac mTOR/p70S6K pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

(2010) Cossette Sanchez Canedo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease

(2010) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1

(2010) Nebojša M. Lalić et al.   MOVEMENT DISORDERS

Serum insulin-like system alterations in patients with spinocerebellar ataxia type 3

(2010) Jonas Alex Morales Saute et al.   MOVEMENT DISORDERS

The cleaved-Caspase-3 antibody is a marker of Caspase-9-like DRONC activity in Drosophila

(2009) Y Fan et al.   CELL DEATH AND DIFFERENTIATION

GSK-3β and control of glucose metabolism and insulin action in human skeletal muscle

(2009) T.P. Ciaraldi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation

(2009) An-Hsun Chou et al.   NEUROCHEMISTRY INTERNATIONAL

Multiple roles of HDAC inhibition in neurodegenerative conditions

(2009) De-Maw Chuang et al.   TRENDS IN NEUROSCIENCES

Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation

(2008) An-Hsun Chou et al.   NEUROBIOLOGY OF DISEASE

The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7

(2008) J. R. Gatchel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyglutamine Genes Interact to Modulate the Severity and Progression of Neurodegeneration in Drosophila

(2008) Derek Lessing et al.   PLOS BIOLOGY