EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

(2020) Yi Le et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis, and cytotoxicity screening of new synthesized imidazolidine‐2‐thiones as VEGFR‐2 enzyme inhibitors

(2020) Islam Zaki et al.   ARCHIV DER PHARMAZIE

Ligand-Based Pharmacophore Modeling, Molecular Docking, and Molecular Dynamic Studies of Dual Tyrosine Kinase Inhibitor of EGFR and VEGFR2

(2020) Frangky Sangande et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual EGFR/VEGF pathway inhibition: a promising strategy for patients with EGFR-mutant NSCLC

(2020) Xiuning Le et al.   Journal of Thoracic Oncology

Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors

(2019) Mahmoud S. Abdelbaset et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeted therapeutic effect against the breast cancer cell line MCF-7 with a CuFe2O4/silica/cisplatin nanocomposite formulation

(2019) B Rabindran Jermy et al.   Beilstein Journal of Nanotechnology

Design, synthesis and biological evaluation of chromenopyrimidines as potential cytotoxic agents

(2018) Nehal M El-Bakhshawangy et al.   Future Medicinal Chemistry

Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study

(2018) Walaa M. El-Husseiny et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Induction of Apoptosis in Human Breast Cancer MCF-7 Cells by a SemiSynthetic Derivative of Artemisinin: A Caspase-Related Mechanism

(2017) Leila Jamalzadeh et al.   Iranian Journal of Biotechnology

Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies

(2016) Alaa A.-M. Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological Evaluation of Some Imidazolidine-2,4-dione and 2-thioxoimidazolidin-4-one Derivatives as Anticoagulant Agents and Inhibition of MCF-7 Breast Cancer Cell Line

(2016) Ashraf A. Mostafa et al.   International Journal of Pharmacology

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting RTK Signaling Pathways in Cancer

(2015) Tarik Regad   Cancers

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach

(2013) Kingkan Sanphanya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors

(2013) Yi-Hui Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cellular Mechanisms Controlling Caspase Activation and Function

(2013) A. B. Parrish et al.   Cold Spring Harbor Perspectives in Biology

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGFR-1 Mediates Endothelial Differentiation and Formation of Blood Vessels in a Murine Model of Infantile Hemangioma

(2011) Elisa Boscolo et al.   AMERICAN JOURNAL OF PATHOLOGY

EGFR Mutations and Lung Cancer

(2011) Gilda da Cunha Santos et al.   Annual Review of Pathology-Mechanisms of Disease

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Synthesis and characterization of new types of halogenated and alkylated imidazolidineiminothiones and a comparative study of their antitumor, antibacterial, and antifungal activities

(2011) Ziad Moussa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bcl2 family proteins in carcinogenesis and the treatment of cancer

(2009) Anna Frenzel et al.   APOPTOSIS

Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agents

(2009) J. Thanusu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization and derivatization of some novel types of mono- and bis-imidazolidineiminothiones and imidazolidineiminodithiones with antitumor, antiviral, antibacterial and antifungal activities – part I

(2009) Ahmed M. Sh. El-Sharief et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Three-dimensional common-feature hypotheses for hypoglycemic flavonyl-2,4-thiazolidinedione derivatives

(2009) Ilkay Yildiz et al.   MEDICINAL CHEMISTRY RESEARCH

Evaluation of indazole-based compounds as a new class of potent KDR/VEGFR-2 inhibitors

(2008) David Bauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure and anti-proliferation function of 5,5-diphenyl-2-thiohydantoin (DPTH) derivatives in vascular endothelial cells

(2008) Cheng-Kuo Cheng et al.   VASCULAR PHARMACOLOGY