Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4

Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength

(2021) Eric R. Samuels et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of Kpnβ1 mediated nuclear import enhances cisplatin chemosensitivity in cervical cancer

(2021) Ru-pin Alicia Chi et al.   BMC CANCER

An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4

(2020) Eric R. Samuels et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dual-Action Ru(II) Complexes with Bulky π-Expansive Ligands: Phototoxicity without DNA Intercalation

(2020) Nicholas P. Toupin et al.   INORGANIC CHEMISTRY

New Trends for Antimalarial Drugs: Synergism between Antineoplastics and Antimalarials on Breast Cancer Cells

(2020) Diana Duarte et al.   Biomolecules

Unusually Slow Internal Conversion in N-Heterocyclic Carbene/Carbanion Cyclometallated Ru(II) Complexes: A Hammett Relationship

(2019) William T. Kender et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules

(2019) Irina Sevrioukova   BIOCHEMISTRY

Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes

(2019) Maarten van Eijk et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model

(2019) Vincent H. S. van Rixel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoactivation of imatinib–antibody conjugate using low-energy visible light from Ru(ii)-polypyridyl cages

(2018) Thomas N. Rohrabaugh et al.   CHEMICAL COMMUNICATIONS

Ru(ii) polypyridyl complexes as photocages for bioactive compounds containing nitriles and aromatic heterocycles

(2018) Ao Li et al.   CHEMICAL COMMUNICATIONS

Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery

(2018) Ogheneochukome Lolodi et al.   CURRENT DRUG METABOLISM

New Ru(ii) complex for dual photochemotherapy: release of cathepsin K inhibitor and 1O2 production

(2018) Thomas N. Rohrabaugh et al.   DALTON TRANSACTIONS

Direct synthesis of α-thio aromatic acids from aromatic amino acids

(2018) Eric R. Samuels et al.   TETRAHEDRON LETTERS

Catch and Release Photosensitizers: Combining Dual-Action Ruthenium Complexes with Protease Inactivation for Targeting Invasive Cancers

(2018) Karan Arora et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An overview of photosubstitution reactions of Ru(II) imine complexes and their application in photobiology and photodynamic therapy

(2017) Jessica K. White et al.   INORGANICA CHIMICA ACTA

Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of the Side Group Functionalities

(2017) Eric R. Samuels et al.   MOLECULAR PHARMACEUTICS

Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition

(2016) Matthew Huisman et al.   CHEMICAL COMMUNICATIONS

New RuIIComplex for Dual Activity: Photoinduced Ligand Release and1O2Production

(2016) Lauren M. Loftus et al.   CHEMISTRY-A EUROPEAN JOURNAL

A ruthenium(ii) based photosensitizer and transferrin complexes enhance photo-physical properties, cell uptake, and photodynamic therapy safety and efficacy

(2016) Pavel Kaspler et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

New Ru(II) Complexes for Dual Photoreactivity: Ligand Exchange and 1O2 Generation

(2015) Jessica D. Knoll et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metabolism-related pharmacokinetic drug−drug interactions with tyrosine kinase inhibitors: current understanding, challenges and recommendations

(2015) Yi Ling Teo et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Excited state investigation of a new Ru(ii) complex for dual reactivity with low energy light

(2015) J. D. Knoll et al.   CHEMICAL COMMUNICATIONS

A luminescent ruthenium(ii) complex for light-triggered drug release and live cell imaging

(2015) Nora Karaoun et al.   CHEMICAL COMMUNICATIONS

Selective Release of Aromatic Heterocycles from Ruthenium Tris(2-pyridylmethyl)amine with Visible Light

(2015) Ao Li et al.   INORGANIC CHEMISTRY

Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model

(2015) Parminder Kaur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Energy Dependence of the Ruthenium(II)-Bipyridine Metal-to-Ligand-Charge-Transfer Excited State Radiative Lifetimes: Effects of ππ*(bipyridine) Mixing

(2015) Ryan A. Thomas et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A novel class of ruthenium-based photosensitizers effectively kills in vitro cancer cells and in vivo tumors

(2015) Jamie Fong et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Combination of Ru(ii) complexes and light: new frontiers in cancer therapy

(2015) Cristina Mari et al.   Chemical Science

Ritonavir-boosted protease inhibitor based therapy: a new strategy in chronic hepatitis C therapy

(2015) Samuel W Brayer et al.   Expert Review of Gastroenterology & Hepatology

Imaging Sites of Inhibition of Proteolysis in Pathomimetic Human Breast Cancer Cultures by Light-Activated Ruthenium Compound

(2015) Suelem D. Ramalho et al.   PLoS One

Inhibition of Cathepsin Activity in a Cell-Based Assay by a Light-Activated Ruthenium Compound

(2014) Tomasz Respondek et al.   ChemMedChem

Photoactive Ru(II) Complexes With Dioxinophenanthroline Ligands Are Potent Cytotoxic Agents

(2014) Achmad N. Hidayatullah et al.   INORGANIC CHEMISTRY

Synthesis, Characterization, and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy

(2014) Angelo Frei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unusually Efficient Pyridine Photodissociation from Ru(II) Complexes with Sterically Bulky Bidentate Ancillary Ligands

(2014) Jessica D. Knoll et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Marked Improvement in Photoinduced Cell Death by a New Tris-heteroleptic Complex with Dual Action: Singlet Oxygen Sensitization and Ligand Dissociation

(2014) Bryan A. Albani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spontaneous Formation in the Dark, and Visible Light-Induced Cleavage, of a Ru–S Bond in Water: A Thermodynamic and Kinetic Study

(2013) Azadeh Bahreman et al.   INORGANIC CHEMISTRY

Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir

(2013) Irina F. Sevrioukova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Photoactivatable metal complexes: from theory to applications in biotechnology and medicine

(2013) N. A. Smith et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Photodynamic inactivation of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with Ru(II)-based type I/type II photosensitizers

(2013) Yaxal Arenas et al.   Photodiagnosis and Photodynamic Therapy

Ruthenium Polypyridyl Complexes Hopping at Anionic Lipid Bilayers through a Supramolecular Bond Sensitive to Visible Light

(2012) Azadeh Bahreman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Luminescent Properties of Ruthenium(II) Complexes with Sterically Expansive Ligands Bound to DNA Defects

(2012) Anna J. McConnell et al.   INORGANIC CHEMISTRY

Excited State Dynamics of Two New Ru(II) Cyclometallated Dyes: Relation to Cells for Solar Energy Conversion and Comparison to Conventional Systems

(2012) Bruno Peña et al.   Journal of Physical Chemistry C

Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

(2012) Brock S. Howerton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer

(2011) Jean-Nicolas Gallant et al.   CANCER BIOLOGY & THERAPY

Effect of Electronic Structure on the Photoinduced Ligand Exchange of Ru(II) Polypyridine Complexes

(2011) Robert N. Garner et al.   INORGANIC CHEMISTRY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Photoactivated Biological Activity of Transition-Metal Complexes

(2010) Ulrich Schatzschneider   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates

(2010) Jiyong Lee et al.   Nature Chemical Biology

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

(2010) I. F. Sevrioukova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Photoactivated chemotherapy (PACT): the potential of excited-state d-block metals in medicine

(2009) Nicola J. Farrer et al.   DALTON TRANSACTIONS

Exploring the cellular accumulation of metal complexes

(2009) Cindy A. Puckett et al.   DALTON TRANSACTIONS

On the Viability of Cyclometalated Ru(II) Complexes for Light-Harvesting Applications

(2009) Paolo G. Bomben et al.   INORGANIC CHEMISTRY

Mechanism of Cellular Uptake of a Ruthenium Polypyridyl Complex†

(2008) Cindy A. Puckett et al.   BIOCHEMISTRY

Solid-Phase Synthesis of Tris-heteroleptic Ruthenium(II) Complexes and Application to Acetylcholinesterase Inhibition

(2008) Seann P. Mulcahy et al.   INORGANIC CHEMISTRY