Targeted and Untargeted Mass Spectrometry Reveals the Impact of High-Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer’s Disease

MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1

(2021) Tessa M Popay et al.   eLife

Placental Metabolomics for Assessment of Sex-specific Differences in Fetal Development During Normal Gestation

(2020) Michelle Saoi et al.   Scientific Reports

Targeted Strategy to Analyze Antiepileptic Drugs in Human Serum by LC-MS/MS and LC-Ion Mobility-MS

(2020) Don E. Davis et al.   ANALYTICAL CHEMISTRY

mzTab-M: A Data Standard for Sharing Quantitative Results in Mass Spectrometry Metabolomics

(2019) Nils Hoffmann et al.   ANALYTICAL CHEMISTRY

Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults

(2019) Minoo Bagheri et al.   Lipids in Health and Disease

Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells

(2019) Kate Elizabeth Hawkins et al.   World Journal of Stem Cells

Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly

(2019) Serena Lazzaro et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility-Imaging Mass Spectrometry and Unsupervised Segmentation

(2019) Berkley M. Ellis et al.   ANALYTICAL CHEMISTRY

Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

(2018) Huajie Li et al.   BIOSCIENCE REPORTS

Sustained high-fat diet modulates inflammation, insulin signalling and cognition in mice and a modified xenin peptide ameliorates neuropathology in a chronic high-fat model

(2018) Paul Denver et al.   DIABETES OBESITY & METABOLISM

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Using Skyline to Analyze Data-Containing Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry Dimensions

(2018) Brendan X. MacLean et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Metabolomic analysis of obesity, metabolic syndrome, and type 2 diabetes: amino acid and acylcarnitine levels change along a spectrum of metabolic wellness

(2018) Diane M. Libert et al.   PeerJ

Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate

(2017) Shilpy Dixit et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

The Skyline ecosystem: Informatics for quantitative mass spectrometry proteomics

(2017) Lindsay K. Pino et al.   MASS SPECTROMETRY REVIEWS

Reversal of high fat diet-induced obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse model of Alzheimer's disease

(2017) Jennifer M. Walker et al.   NEUROBIOLOGY OF DISEASE

Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

(2017) Ann-Charlotte Granholm et al.   JOURNAL OF ALZHEIMERS DISEASE

Challenges, solutions, and recommendations for Alzheimer's disease combination therapy

(2016) James A. Hendrix et al.   Alzheimers & Dementia

Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes

(2016) Sara Tulipani et al.   CLINICA CHIMICA ACTA

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer’s Disease

(2016) Isaura V.A. Martins et al.   JOURNAL OF ALZHEIMERS DISEASE

Untargeted Metabolomics Strategies—Challenges and Emerging Directions

(2016) Alexandra C. Schrimpe-Rutledge et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study

(2015) Therese Tillin et al.   DIABETOLOGIA

Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function

(2015) Miriam E. Bocarsly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma Free Amino Acid Profiles Predict Four-Year Risk of Developing Diabetes, Metabolic Syndrome, Dyslipidemia and Hypertension in Japanese Population

(2015) Minoru Yamakado et al.   Scientific Reports

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

(2014) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Predicting Network Activity from High Throughput Metabolomics

(2013) Shuzhao Li et al.   PLoS Computational Biology

Acylcarnitines

(2012) Marieke G. Schooneman et al.   DIABETES

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

Translational biomarker discovery in clinical metabolomics: an introductory tutorial

(2012) Jianguo Xia et al.   Metabolomics

HMDB 3.0—The Human Metabolome Database in 2013

(2012) David S. Wishart et al.   NUCLEIC ACIDS RESEARCH

Emerging Perspectives on Essential Amino Acid Metabolism in Obesity and the Insulin-Resistant State

(2012) Sean H. Adams   Advances in Nutrition

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Epidemiology of Alzheimer disease

(2011) Christiane Reitz et al.   Nature Reviews Neurology

Diet-induced effects on neuronal and glial elements in the middle-aged rat hippocampus

(2011) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

(2010) E. S. Tai et al.   DIABETOLOGIA

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women

(2009) Sean H. Adams et al.   JOURNAL OF NUTRITION

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

(2008) M. A. Beydoun et al.   Obesity Reviews