Resolvins as potential candidates for the treatment of major depressive disorder

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

(2021) Plinio C. Casarotto et al.   CELL

Effects of n-3 Polyunsaturated Fatty Acid Supplementation in the Prevention and Treatment of Depressive Disorders—A Systematic Review and Meta-Analysis

(2021) Maike Wolters et al.   Nutrients

Receptors for pro‐resolving mediators are increased in Alzheimer's disease brain

(2020) Ceren Emre et al.   BRAIN PATHOLOGY

Intravenous arketamine for treatment-resistant depression: open-label pilot study

(2020) Gustavo C. Leal et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome

(2020) Eric D. Hamlett et al.   GLIA

Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

(2020) Chadi G. Abdallah et al.   NEUROPSYCHOPHARMACOLOGY

Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain

(2020) Siresha Bathina et al.   ARCHIVES OF MEDICAL RESEARCH

Neuroinflammation and depression: A review

(2020) Romain Troubat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Design and Synthesis of Benzene Congeners of Resolvin E2, a Proresolving Lipid Mediator, as Its Stable Equivalents

(2020) Yuto Murakami et al.   ACS Medicinal Chemistry Letters

N-3 PUFA Have Antidepressant-like Effects Via Improvement of the HPA-Axis and Neurotransmission in Rats Exposed to Combined Stress

(2020) Eun-Young Kim et al.   MOLECULAR NEUROBIOLOGY

Hydroxynorketamine Blocks N-Methyl-d-Aspartate Receptor Currents by Binding to Closed Receptors

(2020) Jamie A. Abbott et al.   MOLECULAR PHARMACOLOGY

The efficacy and safety of omega-3 fatty acids on depressive symptoms in perinatal women: a meta-analysis of randomized placebo-controlled trials

(2020) Mi-Mi Zhang et al.   Translational Psychiatry

The duration of the antidepressant-like effects of a single infusion of brain-derived neurotrophic factor into the medial prefrontal cortex in mice

(2020) Satoshi Deyama et al.   BEHAVIOURAL BRAIN RESEARCH

Antidepressant actions of ketamine engage cell-specific translation via eIF4E

(2020) Argel Aguilar-Valles et al.   NATURE

Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation

(2020) Stefania Lamon-Fava et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine

(2019) Satoshi Deyama et al.   AMERICAN JOURNAL OF PSYCHIATRY

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

(2019) Taro Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Esketamine for Treatment-Resistant Depression — First FDA-Approved Antidepressant in a New Class

(2019) Jean Kim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resolvin E3 attenuates allergic airway inflammation via the interleukin-23–interleukin-17A pathway

(2019) Makiko Sato et al.   FASEB JOURNAL

Resolvin D1 as a novel anti-inflammatory marker in manic, depressive and euthymic states of bipolar disorder

(2019) Burcu Kok Kendirlioglu et al.   NORDIC JOURNAL OF PSYCHIATRY

Efficacy of omega-3 PUFAs in depression: A meta-analysis

(2019) Yuhua Liao et al.   Translational Psychiatry

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

(2019) Paraskevi Krashia et al.   Nature Communications

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites

(2019) Chun Yang et al.   Translational Psychiatry

Role of BDNF in the pathophysiology and treatment of depression: Activity‐dependent effects distinguish rapid‐acting antidepressants

(2019) Ronald S. Duman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

(2019) Danielle M. Gerhard et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine

(2019) Satoshi Deyama et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Esketamine is approved in Europe for treating resistant major depressive disorder

(2019) Elisabeth Mahase   BMJ-British Medical Journal

Mechanistic Target of Rapamycin–Independent Antidepressant Effects of ( R )-Ketamine in a Social Defeat Stress Model

(2018) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine

(2018) Sriparna Ghosal et al.   BIOLOGICAL PSYCHIATRY

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair

(2018) Jason Hellmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth

(2018) Christabel Fung-Yih Ho et al.   NEUROCHEMICAL RESEARCH

Resolvin D2 protects against cerebral ischemia/reperfusion injury in rats

(2018) Gang Zuo et al.   Molecular Brain

Resolvin E3 attenuates lipopolysaccharide-induced depression-like behavior in mice

(2018) Satoshi Deyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neurotrophic and Antidepressant Actions of Brain-Derived Neurotrophic Factor Require Vascular Endothelial Growth Factor

(2018) Satoshi Deyama et al.   BIOLOGICAL PSYCHIATRY

A new generation of antidepressants: an update on the pharmaceutical pipeline for novel and rapid-acting therapeutics in mood disorders based on glutamate/GABA neurotransmitter systems

(2018) Samuel T. Wilkinson et al.   DRUG DISCOVERY TODAY

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

(2018) Kenichi Fukumoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of specialized pro-resolving mediator clusters from healthy adults after intravenous low-dose endotoxin and omega-3 supplementation: a methodological validation

(2018) Paul C. Norris et al.   Scientific Reports

Fish oil supplementation attenuates neuroinflammation and alleviates depressive-like behavior in rats submitted to repeated lipopolysaccharide

(2017) Ruili Dang et al.   EUROPEAN JOURNAL OF NUTRITION

Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway

(2017) Satoshi Deyama et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Gax suppresses chemerin/CMKLR1-induced preadipocyte biofunctions through the inhibition of Akt/mTOR and ERK signaling pathways

(2017) Yunqi Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory

(2017) Suku-Maran Shalini et al.   MOLECULAR NEUROBIOLOGY

BDNF release and signaling are required for the antidepressant actions of GLYX-13

(2017) T Kato et al.   MOLECULAR PSYCHIATRY

Effects of a ketamine metabolite on synaptic NMDAR function

(2017) Kanzo Suzuki et al.   NATURE

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

(2017) Satoshi Deyama et al.   PSYCHOPHARMACOLOGY

Hippocampal VEGF is necessary for antidepressant-like behaviors but not sufficient for antidepressant-like effects of ketamine in rats

(2016) Miyeon Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study

(2016) Jaskaran B. Singh et al.   BIOLOGICAL PSYCHIATRY

Expression and cell distribution of leukotriene B4 receptor 1 in the rat brain cortex after experimental subarachnoid hemorrhage

(2016) Zhen-nan Ye et al.   BRAIN RESEARCH

Lipoxin A4 activates ALX/FPR2 receptor to regulate conjunctival goblet cell secretion

(2016) R R Hodges et al.   Mucosal Immunology

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Integrating neuroimmune systems in the neurobiology of depression

(2016) Eric S. Wohleb et al.   NATURE REVIEWS NEUROSCIENCE

GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine

(2016) Rong-Jian Liu et al.   NEUROPSYCHOPHARMACOLOGY

Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents

(2016) Hayato Fukuda et al.   ORGANIC LETTERS

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Activation of autophagy in macrophages by pro-resolving lipid mediators

(2015) Patricia Prieto et al.   Autophagy

Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis

(2015) Laila M. Poisson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)

(2015) Paul E. Greenberg et al.   JOURNAL OF CLINICAL PSYCHIATRY

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

(2015) C Yang et al.   Translational Psychiatry

BDNF Release Is Required for the Behavioral Actions of Ketamine

(2015) A. E. Lepack et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

(2014) Kuan-Pin Su et al.   BIOLOGICAL PSYCHIATRY

Resolvin D1, a Metabolite of Omega-3 Polyunsaturated Fatty Acid, Decreases Post-Myocardial Infarct Depression

(2014) Kim Gilbert et al.   Marine Drugs

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice

(2014) Caroline P. Klein et al.   NEUROPHARMACOLOGY

Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion

(2014) T Larrieu et al.   Translational Psychiatry

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

Proresolution Lipid Mediators in Multiple Sclerosis — Differential, Disease Severity-Dependent Synthesis — A Clinical Pilot Trial

(2013) Harald Prüss et al.   PLoS One

Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation

(2012) Olutayo Odusanwo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Acute Increases in Plasma Mammalian Target of Rapamycin, Glycogen Synthase Kinase-3β, and Eukaryotic Elongation Factor 2 Phosphorylation After Ketamine Treatment in Three Depressed Patients

(2012) Chun Yang et al.   BIOLOGICAL PSYCHIATRY

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region

(2012) Xiaoyun Guo et al.   NEUROSCIENCE LETTERS

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free Radical Oxidation of Polyunsaturated Lipids: New Mechanistic Insights and the Development of Peroxyl Radical Clocks

(2011) Derek A. Pratt et al.   ACCOUNTS OF CHEMICAL RESEARCH

Monitoring Ketamine Treatment Response in a Depressed Patient via Peripheral Mammalian Target of Rapamycin Activation

(2011) Magdalena C. Denk et al.   AMERICAN JOURNAL OF PSYCHIATRY

Brain-Derived Neurotrophic Factor Val66Met Allele Impairs Basal and Ketamine-Stimulated Synaptogenesis in Prefrontal Cortex

(2011) Rong-Jian Liu et al.   BIOLOGICAL PSYCHIATRY

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents

(2009) Tatjana Haitina et al.   BMC GENOMICS

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

(2009) Taisuke Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy

(2009) Kuan-Pin Su et al.   JOURNAL OF CLINICAL PSYCHIATRY

PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus

(2008) Venugopal Reddy Venna et al.   PSYCHONEUROENDOCRINOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY

Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin

(2007) Byung Woo Kim et al.   CELLULAR SIGNALLING