Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury

Recruitment of γδ T cells to the lesion via the CCL2/CCR2 signaling after spinal cord injury

(2021) Ping Xu et al.   Journal of Neuroinflammation

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

(2020) Wei Liu et al.   Journal of Neuroinflammation

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury

(2020) Jiaxing Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

(2020) Dongdong Jiang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease

(2019) Jean-Christophe Delpech et al.   TRENDS IN NEUROSCIENCES

Harpagide inhibits neuronal apoptosis and promotes axonal regeneration after spinal cord injury in rats by activating the Wnt/β-catenin signaling pathway

(2019) Yuluo Rong et al.   BRAIN RESEARCH BULLETIN

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy

(2019) Yuluo Rong et al.   Cell Death & Disease

Decreased expression of lncRNA Malat1 in rat spinal cord contributes to neuropathic pain by increasing neuron excitability after brachial plexus avulsion

(2019) Chong Meng et al.   Journal of Pain Research

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a

(2019) Lin Song et al.   Nature Communications

Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1

(2019) Yuluo Rong et al.   Aging-US

Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival

(2019) Mary C. Patton et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice

(2019) Chao Wang et al.   Journal of Neuroinflammation

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

(2019) Yuqin Men et al.   Nature Communications

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Microenvironment Imbalance of Spinal Cord Injury

(2018) Baoyou Fan et al.   CELL TRANSPLANTATION

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

(2018) Shoubo Chen et al.   Journal of Neuroinflammation

Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation

(2018) Lin-Li Lv et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

(2018) Amrita Datta Chaudhuri et al.   Cell Death & Disease

Elevated Plasma MCP-1 Concentration Following Traumatic Brain Injury as a Potential “Predisposition” Factor Associated with an Increased Risk for Subsequent Development of Alzheimer's Disease

(2018) Lap Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology

(2018) Tore Skotland et al.   JOURNAL OF LIPID RESEARCH

Novel multi-drug delivery hydrogel using scar-homing liposomes improves spinal cord injury repair

(2018) Qingqing Wang et al.   Theranostics

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Truncated TrkB.T1-Mediated Astrocyte Dysfunction Contributes to Impaired Motor Function and Neuropathic Pain after Spinal Cord Injury

(2017) Jessica J. Matyas et al.   JOURNAL OF NEUROSCIENCE

Chemokine CCL2–CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus

(2017) Dai-Shi Tian et al.   JOURNAL OF NEUROSCIENCE

Traumatic Spinal Cord Injury—Repair and Regeneration

(2017) Christopher S. Ahuja et al.   NEUROSURGERY

Neuronal survival in the brain: neuron type-specific mechanisms

(2017) Ulrich Pfisterer et al.   Cell Death & Disease

Cerebral mast cells contribute to postoperative cognitive dysfunction by promoting blood brain barrier disruption

(2016) Susu Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1

(2016) Kenta Kawabata et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury

(2016) Soya Kawabata et al.   Stem Cell Reports

Macrophage activation and its role in repair and pathology after spinal cord injury

(2015) John C. Gensel et al.   BRAIN RESEARCH

Innate and adaptive immune responses in the CNS

(2015) Ari Waisman et al.   LANCET NEUROLOGY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

CCL2-CCR2 Signaling in Disease Pathogenesis

(2015) Tracy O’Connor et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

(2013) Shambhunath Bose et al.   ARCHIVES OF PHARMACAL RESEARCH

Monocyte chemoattractant protein-1 and the blood–brain barrier

(2013) Yao Yao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain

(2012) Zhi-Jun Zhang et al.   Journal of Neuroinflammation

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

(2011) S. Nori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of CCL2 (MCP-1) in Traumatic Brain Injury (TBI): Evidence from Severe TBI Patients and CCL2−/− Mice

(2010) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Role of Chemokines in CNS Health and Pathology: A Focus on the CCL2/CCR2 and CXCL8/CXCR2 Networks

(2009) Bridgette D Semple et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY