4.2 Review

Synthesis and Application of Iron Oxide Nanoparticles in Bone Tissue Repair

Journal

JOURNAL OF NANOMATERIALS
Volume 2021, Issue -, Pages -

Publisher

HINDAWI LTD
DOI: 10.1155/2021/3762490

Keywords

-

Funding

  1. National Natural Science Foundation of China [11972065]
  2. Beijing Natural Science Foundation [L202006]

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IONPs can accelerate biomineralization under a magnetic field, synthesize scaffolds that promote stem cell attachment, proliferation, and bone differentiation when combined with polymers, and mark the location of drugs in the body to track bone repair progress.
Nanoparticles play a vital role in bone tissue repair engineering, especially iron oxide nanoparticles (IONPs), which have magnetic properties, semiconductor properties, and nontoxicity at the same time, and their applications in biomedicine have received widespread attention. This review summarizes the excellent performance of IONPs in enhancing scaffold functions, promoting stem cell differentiation, and labeling positioning, in order to understand the research progress and future development trends of IONPs in bone tissue repair engineering, as well as the security issues. Firstly, IONPs can affect the expression of genes and proteins to accelerate the process of biomineralization under a magnetic field. Then, the composite of IONPs and polymers can synthesize a scaffold which can promote the attachment, proliferation, and bone differentiation of stem cells. Furthermore, IONPs can also mark the location of drugs in the body to follow up the process of bone repair. Therefore, extensive research on the manufacturing and application range of IONPs is of great significance to bone tissue repair engineering.

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