Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)

Patient perspectives on the treatment burden of injectable medication for hereditary angioedema

(2021) Cristine Radojicic et al.   ALLERGY AND ASTHMA PROCEEDINGS

Physician and patient perspectives on the management of hereditary angioedema: a survey on treatment burden and needs

(2021) Marc A. Riedl et al.   ALLERGY AND ASTHMA PROCEEDINGS

Heterocyclic Compounds: Pharmacology of Pyrazole Analogs From Rational Structural Considerations

(2021) Rafael Fernades Costa et al.   Frontiers in Pharmacology

Randomized Trial of the Efficacy and Safety of Berotralstat (BCX7353) as an Oral Prophylactic Therapy for Hereditary Angioedema: Results of APeX-2 Through 48 Weeks (Part 2)

(2021) H. James Wedner et al.   Journal of Allergy and Clinical Immunology-In Practice

Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: a randomized, double-blind, placebo-controlled phase 3 trial

(2020) Bruce Zuraw et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

US HAEA Medical Advisory Board 2020 Guidelines for the Management of Hereditary Angioedema

(2020) Paula J. Busse et al.   Journal of Allergy and Clinical Immunology-In Practice

Structures of full-length plasma kallikrein bound to highly specific inhibitors describe a new mode of targeted inhibition

(2019) James R. Partridge et al.   JOURNAL OF STRUCTURAL BIOLOGY

Oral plasma kallikrein inhibitor BCX7353 for treatment of hereditary angioedema

(2019) Jacqueline R Hwang et al.   Immunotherapy

Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The OPuS-2 study

(2018) M. A. Riedl et al.   ALLERGY

The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review

(2018) Jaya Dwivedi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

(2018) Khalid Karrouchi et al.   MOLECULES

Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema

(2018) Emel Aygören-Pürsün et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Outlook of Pyrazole Analogs: A Mini Review

(2017) Swastika Ganguly et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study

(2016) M. Cornpropst et al.   ALLERGY

Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors

(2016) Zhe Li et al.   ACS Medicinal Chemistry Letters

Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor

(2015) Peng Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of hereditary angioedema: a review (CME)

(2014) Neeti Bhardwaj et al.   TRANSFUSION

BCX-4161, a Small Molecule and Orally Bioavailable Plasma Kallikrein Inhibitor for the Treatment of Hereditary Angioedema

(2013) Shanta Bantia et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The DINGO dataset: a comprehensive set of data for the SAMPL challenge

(2011) Janet Newman et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Factor Xa Inhibitors: Next-Generation Antithrombotic Agents

(2010) Donald J. P. Pinto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

(2010) Fraser F. Fleming et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores

(2009) Pravin L. Kotian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mutational spectrum of the C1INH (SERPING1) gene in patients with hereditary angioedema

(2008) T. Göβwein et al.   CYTOGENETIC AND GENOME RESEARCH