Discovery of Potent and Broad-Spectrum Pyrazolopyridine-Containing Antivirals against Enteroviruses D68, A71, and Coxsackievirus B3 by Targeting the Viral 2C Protein

Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors

(2021) Chunlong Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiological dynamics of enterovirus D68 in the United States and implications for acute flaccid myelitis

(2021) Sang Woo Park et al.   Science Translational Medicine

Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses

(2021) Yanmei Hu et al.   ACS Infectious Diseases

Acute Flaccid Myelitis: A Clinical Review

(2020) Olwen C. Murphy et al.   SEMINARS IN NEUROLOGY

Enterovirus and Encephalitis

(2020) Bo-Shiun Chen et al.   Frontiers in Microbiology

Enterovirus D68 Antivirals: Past, Present, and Future

(2020) Yanmei Hu et al.   ACS Infectious Diseases

Development of broad-spectrum enterovirus antivirals based on quinoline scaffold

(2020) Rami Musharrafieh et al.   BIOORGANIC CHEMISTRY

Pharmacological Characterization of the Mechanism of Action of R523062, a Promising Antiviral for Enterovirus D68

(2020) Chunlong Ma et al.   ACS Infectious Diseases

The Structure, Function, and Mechanisms of Action of Enterovirus Non-structural Protein 2C

(2020) Shao-Hua Wang et al.   Frontiers in Microbiology

Recent advances in the understanding of enterovirus A71 infection: a focus on neuropathogenesis

(2020) Han Kang Tee et al.   Expert Review of Anti-Infective Therapy

Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2Apro Inhibitor

(2019) Rami Musharrafieh et al.   JOURNAL OF VIROLOGY

Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role

(2019) Jolene R. Bowers et al.   mBio

Discovery of quinoline analogs as potent antivirals against enterovirus D68 (EV-D68)

(2019) Rami Musharrafieh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Current Understanding of Human Enterovirus D68

(2019) Jing Sun et al.   Viruses-Basel

Acute Flaccid Myelitis: Something Old and Something New

(2019) David M. Morens et al.   mBio

Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

(2019) Lisa Bauer et al.   ACS Infectious Diseases

Recent progress and challenges in drug development to fight hand, foot and mouth disease

(2019) Ze Qin Lim et al.   Expert Opinion on Drug Discovery

Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review

(2019) Hixon et al.   Viruses-Basel

Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis

(2019) Nischay Mishra et al.   mBio

A Novel Capsid Binding Inhibitor Displays Potent Antiviral Activity against Enterovirus D68

(2019) Chunlong Ma et al.   ACS Infectious Diseases

The association between acute flaccid myelitis (AFM) and Enterovirus D68 (EV-D68) – what is the evidence for causation?

(2018) Amalie Dyda et al.   Eurosurveillance

Synthesis and Structure–Activity Relationship (SAR) Studies of Novel Pyrazolopyridine Derivatives as Inhibitors of Enterovirus Replication

(2018) Yanpeng Xing et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enterovirus D68 and acute flaccid myelitis—evaluating the evidence for causality

(2018) Kevin Messacar et al.   LANCET INFECTIOUS DISEASES

The life cycle of non-polio enteroviruses and how to target it

(2018) Jim Baggen et al.   NATURE REVIEWS MICROBIOLOGY

The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers

(2018) Margarita Pons-Salort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Causation of Acute Flaccid Paralysis by Myelitis and Myositis in Enterovirus-D68 Infected Mice Deficient in Interferon αβ/γ Receptor Deficient Mice

(2018) John Morrey et al.   Viruses-Basel

Crystal structure of a soluble fragment of poliovirus 2CATPase

(2018) Hongxin Guan et al.   PLoS Pathogens

Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis

(2018) Kevin Messacar et al.   NEUROLOGY

Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice

(2018) Brett L. Hurst et al.   VIROLOGY

Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells

(2018) David M. Brown et al.   mBio

Evaluating Treatment Efficacy in a Mouse Model of Enterovirus D68–Associated Paralytic Myelitis

(2017) Alison M Hixon et al.   JOURNAL OF INFECTIOUS DISEASES

Direct-acting antivirals and host-targeting strategies to combat enterovirus infections

(2017) Lisa Bauer et al.   Current Opinion in Virology

A mouse model of paralytic myelitis caused by enterovirus D68

(2017) Alison M. Hixon et al.   PLoS Pathogens

Crystal structure of 2C helicase from enterovirus 71

(2017) Hongxin Guan et al.   Science Advances

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C

(2016) Rachel Ulferts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

2-Year Efficacy, Immunogenicity, and Safety of Vigoo Enterovirus 71 Vaccine in Healthy Chinese Children: A Randomized Open-Label Study

(2016) Mingwei Wei et al.   JOURNAL OF INFECTIOUS DISEASES

Global emergence of enterovirus D68: a systematic review

(2016) Charlotte Carina Holm-Hansen et al.   LANCET INFECTIOUS DISEASES

EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases

(2016) Qunying Mao et al.   Emerging Microbes & Infections

Discovery of Structurally Diverse Small-Molecule Compounds with Broad Antiviral Activity against Enteroviruses

(2015) Jun Zuo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

(2013) Feng-Cai Zhu et al.   LANCET

Approach to the Library of Fused Pyridine-4-carboxylic Acids by Combes-Type Reaction of Acyl Pyruvates and Electron-Rich Amino Heterocycles

(2010) Dmitriy M. Volochnyuk et al.   JOURNAL OF COMBINATORIAL CHEMISTRY