Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular Inflammation

Intercellular Adhesion Molecule 1 Functions as an Efferocytosis Receptor in Inflammatory Macrophages

(2020) Hannah L. Wiesolek et al.   AMERICAN JOURNAL OF PATHOLOGY

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

(2020) Trinidad Montero-Melendez et al.   Nature Communications

Hematopoiesis and Cardiovascular Disease

(2020) Wolfram C. Poller et al.   CIRCULATION RESEARCH

Reducing Senescent Cell Burden in Aging and Disease

(2020) Robert J. Pignolo et al.   TRENDS IN MOLECULAR MEDICINE

Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression

(2020) Jesse W. Williams et al.   NATURE IMMUNOLOGY

Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

(2020) Daniel J. Tyrrell et al.   Nature Reviews Cardiology

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 promotes efferocytosis in aging by limiting senescent cell‐induced MerTK cleavage

(2019) Nicholas Rymut et al.   FASEB JOURNAL

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

(2018) Charles N. Serhan et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages in radiation injury: a new therapeutic target

(2018) Lydia Meziani et al.   OncoImmunology

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Age-associated vascular inflammation promotes monocytosis during atherogenesis

(2016) Wei Du et al.   AGING CELL

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

(2016) Christopher D. Wiley et al.   Cell Metabolism

Bone Marrow Takes Center Stage in Cardiovascular Disease

(2016) Filip K. Swirski et al.   CIRCULATION RESEARCH

Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review)

(2016) Bjorn Baselet et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging

(2016) Kira Young et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Quantitative and Qualitative Analysis of Bone Marrow CD8+ T Cells from Different Bones Uncovers a Major Contribution of the Bone Marrow in the Vertebrae

(2016) Sulima Geerman et al.   Frontiers in Immunology

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

(2016) Ana Teresa Pinto et al.   Scientific Reports

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner

(2014) L. Shao et al.   BLOOD

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Identification of a Tissue-Specific, C/EBP -Dependent Pathway of Differentiation for Murine Peritoneal Macrophages

(2013) D. W. Cain et al.   JOURNAL OF IMMUNOLOGY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer

(2013) Sarah C. Darby et al.   NEW ENGLAND JOURNAL OF MEDICINE

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque

(2010) Lesca Miriam Holdt et al.   ATHEROSCLEROSIS

Understanding Radiation-Induced Vascular Disease⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2010) Neal L. Weintraub et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Vascular Damage as an Underlying Mechanism of Cardiac and Cerebral Toxicity in Irradiated Cancer Patients

(2010) F. A. Stewart et al.   RADIATION RESEARCH

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Single-Dose and Fractionated Irradiation Promote Initiation and Progression of Atherosclerosis and Induce an Inflammatory Plaque Phenotype in ApoE−/− Mice

(2008) Saske Hoving et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cause-Specific Late Mortality Among 5-Year Survivors of Childhood Cancer: The Childhood Cancer Survivor Study

(2008) A. C. Mertens et al.   JNCI-Journal of the National Cancer Institute