Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction

(2020) Wei Wen et al.   Frontiers in Immunology

Crystal Structures of the Full-Length Murine and Human Gasdermin D Reveal Mechanisms of Autoinhibition, Lipid Binding, and Oligomerization

(2019) Zhonghua Liu et al.   IMMUNITY

Nlrp3 inflammasome activation and Gasdermin D-driven pyroptosis are immunopathogenic upon gastrointestinal norovirus infection

(2019) Hanne Dubois et al.   PLoS Pathogens

Seneca Valley Virus 2C and 3Cpro Induce Apoptosis via Mitochondrion-Mediated Intrinsic Pathway

(2019) Tingting Liu et al.   Frontiers in Microbiology

NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology

(2019) Xiaolong He et al.   Cellular & Molecular Immunology

Seneca Valley virus 2C and 3C inhibit type I interferon production by inducing the degradation of RIG-I

(2019) Wei Wen et al.   VIROLOGY

Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease

(2018) Qiang Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Gasdermin D C-Terminal Domains Reveal Mechanisms of Autoinhibition

(2018) Zhonghua Liu et al.   STRUCTURE

Seneca Valley Virus 3C pro abrogates the IRF3- and IRF7-mediated innate immune response by degrading IRF3 and IRF7

(2018) Qiao Xue et al.   VIROLOGY

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

(2018) Alex C Stabell et al.   eLife

Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Cleaves Porcine DCP1a To Attenuate Its Antiviral Activity

(2018) Ran Tao et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage

(2017) Suhong Qian et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

(2017) Siyun Kuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Histopathological, immunohistochemical, and ultrastructural evidence of spontaneous Senecavirus A-induced lesions at the choroid plexus of newborn piglets

(2017) Thalita E. S. Oliveira et al.   Scientific Reports

AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71-Infected Neuronal Cells Restricts Viral Replication

(2017) Thinesshwary Yogarajah et al.   Scientific Reports

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Detection of the Emerging Picornavirus Senecavirus A in Pigs, Mice, and Houseflies

(2016) Lok R. Joshi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The First Identification and Complete Genome of Senecavirus A Affecting Pig with Idiopathic Vesicular Disease in China

(2016) Q. Wu et al.   Transboundary and Emerging Diseases

Isolation and full-genome sequencing of Seneca Valley virus in piglets from China, 2016

(2016) Suhong Qian et al.   Virology Journal

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Seneca Valley Virus 3Cpro Substrate Optimization Yields Efficient Substrates for Use in Peptide-Prodrug Therapy

(2015) Linde A. Miles et al.   PLoS One

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

Selective Tropism of Seneca Valley Virus for Variant Subtype Small Cell Lung Cancer

(2013) J. T. Poirier et al.   JNCI-Journal of the National Cancer Institute

A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models

(2010) L. Yu et al.   NEURO-ONCOLOGY

Initial testing of the replication competent Seneca Valley virus (NTX-010) by the pediatric preclinical testing program

(2010) Christopher L. Morton et al.   PEDIATRIC BLOOD & CANCER

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Complete genome sequence analysis of Seneca Valley virus-001, a novel oncolytic picornavirus

(2008) L. M. Hales et al.   JOURNAL OF GENERAL VIROLOGY