Evaluating parameters affecting drug fate at the intramuscular injection site

Towards in vitro in vivo correlation for modified release subcutaneously administered insulins

(2020) Frederik Bock et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Novel Applications of an In Vitro Injection Model System to Study Bioperformance: Case Studies with Different Drug Modalities

(2020) Sharadvi Thati et al.   Journal of Pharmaceutical Innovation

Novel technology for storage and distribution of live vaccines and other biological medicines at ambient temperature

(2020) Irnela Bajrovic et al.   Science Advances

Predicting bioavailability of monoclonal antibodies after subcutaneous administration: Open innovation challenge

(2020) Manuel Sánchez-Félix et al.   ADVANCED DRUG DELIVERY REVIEWS

Comparative Clinical Pharmacokinetics a1 nd Pharmacodynamics of HIV-1 Integrase Strand Transfer Inhibitors: An Updated Review

(2020) Anthony T. Podany et al.   CLINICAL PHARMACOKINETICS

Comparison of intramuscular and intravenous pharmacokinetics of ginsenosides in humans after dosing XueShuanTong, a lyophilized extract of Panax notoginseng roots

(2020) Hai-Yan Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Higher plasma asparaginase activity after intramuscular than intravenous Erwinia asparaginase

(2020) John C. Panetta et al.   PEDIATRIC BLOOD & CANCER

An in vivo platform to select and evolve aggregation-resistant proteins

(2020) Jessica S. Ebo et al.   Nature Communications

A 96-well culture platform enables longitudinal analyses of engineered human skeletal muscle microtissue strength

(2020) Mohammad E. Afshar et al.   Scientific Reports

The Structure and Role of Intramuscular Connective Tissue in Muscle Function

(2020) Peter P. Purslow   Frontiers in Physiology

From micro to nano: evolution and impact of drug delivery in treating disease

(2020) Jeff Hrkach et al.   Drug Delivery and Translational Research

Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours

(2020) Aslan Mansurov et al.   Nature Biomedical Engineering

Harnessing nerve–muscle cell interactions for biomaterials‐based skeletal muscle regeneration

(2020) Naagarajan Narayanan et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Pharmacokinetics, safety and tolerability of long‐acting parenteral intramuscular injection formulations of doravirine

(2020) Ka Lai Yee et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Pharmacokinetics and bioavailability of tildipirosin in rabbits following single‐dose intravenous and intramuscular administration

(2020) Jincheng Xiong et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Historical development of simulated body fluids used in biomedical applications: A review

(2020) Bengi Yilmaz et al.   MICROCHEMICAL JOURNAL

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

(2019) Bahman Homayun et al.   Pharmaceutics

Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy

(2019) Koichi Sasaki et al.   Science Advances

Regulatory aspects and quality controls of polymer-based parenteral long-acting drug products: the challenge of approving copies

(2019) Francesca Selmin et al.   DRUG DISCOVERY TODAY

On the characterization of interstitial fluid flow in the skeletal muscle endomysium

(2019) Qiuyun Wang et al.   Journal of the Mechanical Behavior of Biomedical Materials

Strategic design of extracellular vesicle drug delivery systems

(2018) James P.K. Armstrong et al.   ADVANCED DRUG DELIVERY REVIEWS

Study on the in situ aggregation of liposomes with negatively charged phospholipids for use as injectable depot formulation

(2018) Lisa Rahnfeld et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Excipients in parenteral formulations: selection considerations and effective utilization with small molecules and biologics

(2018) Bindhu Madhavi Rayaprolu et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Cabotegravir in the treatment and prevention of Human Immunodeficiency Virus-1

(2018) Tristan D. McPherson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Intramuscular and subcutaneous drug depot characterization of a long-acting cabotegravir nanoformulation by MALDI IMS

(2018) M. Reid Groseclose et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies

(2018) Hanne Kinnunen Bown et al.   JOURNAL OF CONTROLLED RELEASE

The expanding role of prodrugs in contemporary drug design and development

(2018) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of Body Temperature by the Nervous System

(2018) Chan Lek Tan et al.   NEURON

Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

(2018) Chun-Woong Park et al.   Drug Design Development and Therapy

Polymeric Micelles of Biodegradable Diblock Copolymers: Enhanced Encapsulation of Hydrophobic Drugs

(2018) Yasser Hussein et al.   Materials

Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use

(2018) Ousama Rachid et al.   Pharmaceutics

Protein aggregation – Mechanisms, detection, and control

(2018) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

LB1552 Evaluation of local inflammatory reactions following subcutaneous injection of a pro-inflammatory cocktail in a fully human ex vivo skin model

(2018) C. Jardet et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Fascia thickness, aging and flexibility: is there an association?

(2018) Jan Wilke et al.   JOURNAL OF ANATOMY

The contribution of the in-vivo fate of an oil depot to drug absorption

(2017) R.W. Kalicharan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Factors affecting the physical stability (aggregation) of peptide therapeutics

(2017) Karolina L. Zapadka et al.   Interface Focus

Evaluation of dynamic changes in interstitial fluid proteome following microdialysis probe insertion trauma in trapezius muscle of healthy women

(2017) Maria V. Turkina et al.   Scientific Reports

Collagen interactions: Drug design and delivery

(2016) Bo An et al.   ADVANCED DRUG DELIVERY REVIEWS

Fundamental understanding of drug absorption from a parenteral oil depot

(2016) Raween W. Kalicharan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effectiveness of pegaspargase, gemcitabine, and oxaliplatin (P-GEMOX) chemotherapy combined with radiotherapy in newly diagnosed, stage IE to IIE, nasal-type, extranodal natural killer/T-cell lymphoma

(2016) Wen Wei et al.   Hematology

Spatial distribution of oil depots monitored in human muscle using MRI

(2016) R.W. Kalicharan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Synthesis, carbonic anhydrase I and II isoenzymes inhibition properties, and antibacterial activities of novel tetralone-based 1,4-benzothiazepine derivatives

(2016) Mustafa Ceylan et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Simultaneous magnetic resonance imaging and pharmacokinetic analysis of intramuscular depots

(2016) Mareike Probst et al.   JOURNAL OF CONTROLLED RELEASE

Subcutaneous Injection Volume of Biopharmaceuticals—Pushing the Boundaries

(2016) Roman Mathaes et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetic properties of intramuscular versus oral syrup paracetamol in Plasmodium falciparum malaria

(2016) Thanaporn Wattanakul et al.   MALARIA JOURNAL

Analysis of fluid movement in skeletal muscle using fluorescent microspheres

(2016) Loribeth Q. Evertz et al.   MUSCLE & NERVE

A collagen-binding EGFR antibody fragment targeting tumors with a collagen-rich extracellular matrix

(2016) Hui Liang et al.   Scientific Reports

Fascial Disorders: Implications for Treatment

(2016) Antonio Stecco et al.   PM&R

Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions

(2015) Jean W. Wassenaar et al.   BIOMATERIALS

Histological confirmation of needle tip position during ultrasound-guided interscalene block: a randomized comparison between the intraplexus and the periplexus approach

(2015) Jennifer J. Szerb et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Acid-Base Homeostasis

(2015) L. L. Hamm et al.   Clinical Journal of the American Society of Nephrology

Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy

(2015) Sima I. Patel et al.   CNS DRUGS

A review of aripiprazole long-acting injection

(2015) Pierre Chue et al.   CURRENT MEDICAL RESEARCH AND OPINION

Capreomycin oleate microparticles for intramuscular administration: Preparation, in vitro release and preliminary in vivo evaluation

(2015) Adrián Cambronero-Rojas et al.   JOURNAL OF CONTROLLED RELEASE

In vitro-in vivo correlation of parenteral risperidone polymeric microspheres

(2015) Jie Shen et al.   JOURNAL OF CONTROLLED RELEASE

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components

(2015) Hanne M. Kinnunen et al.   JOURNAL OF CONTROLLED RELEASE

Long-term distribution of biodegradable microparticles in rat muscle quantified noninvasively by MRI

(2015) Jacques Kameni Tcheudji et al.   MAGNETIC RESONANCE IN MEDICINE

Examination of Thermal Unfolding and Aggregation Profiles of a Series of Developable Therapeutic Monoclonal Antibodies

(2015) Mark L. Brader et al.   MOLECULAR PHARMACEUTICS

Long-Acting Injectable Hormonal Dosage Forms for Contraception

(2015) Linfeng Wu et al.   PHARMACEUTICAL RESEARCH

Modeling the Time Course of the Tissue Responses to Intramuscular Long-acting Paliperidone Palmitate Nano-/Microcrystals and Polystyrene Microspheres in the Rat

(2015) Nicolas Darville et al.   TOXICOLOGIC PATHOLOGY

Formulation and pharmacology of long-acting cabotegravir

(2015) Christine Trezza et al.   Current Opinion in HIV and AIDS

Simulated Biological Fluids with Possible Application in Dissolution Testing

(2015) Margareth R. C. Marques et al.   DISSOLUTION TECHNOLOGIES

Native metastable prefibrillar oligomers are the most neurotoxic species among amyloid aggregates

(2014) Marco Diociaiuti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy

(2014) Leslie A. Rowland et al.   BIOLOGICAL REVIEWS

Skeletal Muscle: A Brief Review of Structure and Function

(2014) Walter R. Frontera et al.   CALCIFIED TISSUE INTERNATIONAL

Injectable testosterone undecanoate for the treatment of hypogonadism

(2014) Giovanni Corona et al.   EXPERT OPINION ON PHARMACOTHERAPY

Pharmacokinetics of olanzapine long-acting injection

(2014) Stephan Heres et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Rituals in nursing: intramuscular injections

(2014) Kathleen Greenway   JOURNAL OF CLINICAL NURSING

Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site

(2014) Hanne M. Kinnunen et al.   JOURNAL OF CONTROLLED RELEASE

Intramuscular Administration of Paliperidone Palmitate Extended-Release Injectable Microsuspension Induces a Subclinical Inflammatory Reaction Modulating the Pharmacokinetics in Rats

(2014) Nicolas Darville et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Long-Acting Atypical Antipsychotics: Characterization of the Local Tissue Response

(2014) Sara Montminy Paquette et al.   PHARMACEUTICAL RESEARCH

Double trouble-Buffer selection and His-tag presence may be responsible for nonreproducibility of biomedical experiments

(2014) Karolina A. Majorek et al.   PROTEIN SCIENCE

Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers

(2014) Chuting Gong et al.   Acta Pharmaceutica Sinica B

Non-Arrhenius Protein Aggregation

(2013) Wei Wang et al.   AAPS Journal

Development and Validation of a Discriminative Dissolution Test for Betamethasone Sodium Phosphate and Betamethasone Dipropionate Intramuscular Injectable Suspension

(2013) Alice Simon et al.   AAPS PHARMSCITECH

Comparative pharmacokinetics of cefuroxime lysine after single intravenous, intraperitoneal and intramuscular administration to rats

(2012) Long-shan Zhao et al.   ACTA PHARMACOLOGICA SINICA

Injectable and implantable sustained release naltrexone in the treatment of opioid addiction

(2012) Nikolaj Kunøe et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Discomfort from an Alkaline Formulation Delivered Subcutaneously in Humans

(2012) W. Kenneth Ward et al.   CLINICAL DRUG INVESTIGATION

Accelerated in-vitro release testing methods for extended-release parenteral dosage forms

(2012) Jie Shen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

The Slowly Aggregating Salmon Calcitonin: A Useful Tool for the Study of the Amyloid Oligomers Structure and Activity

(2011) Marco Diociaiuti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Validation of USP apparatus 4 method for microsphere in vitro release testing using Risperdal® Consta®

(2011) Archana Rawat et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Interventions to Promote Adherence With Oral Agents

(2011) Susan M. Schneider et al.   Seminars in Oncology Nursing

Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation

(2010) Triantafyllos Stylianopoulos et al.   BIOPHYSICAL JOURNAL

Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix

(2010) Rolf K. Reed et al.   CARDIOVASCULAR RESEARCH

Olanzapine Long-Acting Injection

(2010) James E. Frampton   DRUGS

The microvacuolar system: how connective tissue sliding works

(2010) J. C. Guimberteau et al.   Journal of Hand Surgery-European Volume

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mind Your Salts: When the Inactive Constituent Isn't

(2010) R. R. Neubig   MOLECULAR PHARMACOLOGY

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Collagen Structure and Stability

(2009) Matthew D. Shoulders et al.   Annual Review of Biochemistry

Collagens

(2009) Marion K. Gordon et al.   CELL AND TISSUE RESEARCH

Pharmacokinetics of Biotech Drugs: Peptides, Proteins and Monoclonal Antibodies

(2009) Jiunn Lin   CURRENT DRUG METABOLISM

Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection

(2009) Ann L. Daugherty et al.   JOURNAL OF DRUG TARGETING

Impact of Warm Compresses on Local Injection-Site Reactions with Self-Administered Glatiramer Acetate

(2009) Helen Jolly et al.   JOURNAL OF NEUROSCIENCE NURSING

Control of Oxygen Uptake during Exercise

(2009) DAVID C. POOLE et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The Impact of PEGylation on Biological Therapies

(2008) Francesco M Veronese et al.   BIODRUGS

Comparison of Measured and Calculated Bicarbonate Values

(2008) V. Kumar et al.   CLINICAL CHEMISTRY

Effects of sodium phosphate buffer on horseradish peroxidase thermal stability

(2008) L. Haifeng et al.   JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY

Evaluating Drug Efficacy and Toxicology in Three Dimensions: Using Synthetic Extracellular Matrices in Drug Discovery

(2007) Glenn D. Prestwich   ACCOUNTS OF CHEMICAL RESEARCH