The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

Dinosaur Energetics: Setting the Bounds on Feasible Physiologies and Ecologies

(2013) Andrew Clarke   AMERICAN NATURALIST

Gene loss, thermogenesis, and the origin of birds

(2013) Stuart A. Newman et al.   Annals of the New York Academy of Sciences

New crystal structures of PII-type ATPases: excitement continues

(2013) Chikashi Toyoshima et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sarcolipin trumps β-adrenergic receptor signaling as the favored mechanism for muscle-based diet-induced thermogenesis

(2013) Eric Bombardier et al.   FASEB JOURNAL

Ablation of sarcolipin decreases the energy requirements for Ca2+transport by sarco(endo)plasmic reticulum Ca2+-ATPases in resting skeletal muscle

(2013) Eric Bombardier et al.   FEBS LETTERS

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Sarco(endo)plasmic Reticulum Calcium ATPase (SERCA) Inhibition by Sarcolipin Is Encoded in Its Luminal Tail

(2013) Przemek A. Gorski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarcolipin Protein Interaction with Sarco(endo)plasmic Reticulum Ca2+ATPase (SERCA) Is Distinct from Phospholamban Protein, and Only Sarcolipin Can Promote Uncoupling of the SERCA Pump

(2013) Sanjaya K. Sahoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio)

(2013) A. G. Little et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Endogenous and maximal sarcoplasmic reticulum calcium content and calsequestrin expression in type I and type II human skeletal muscle fibres

(2013) C. R. Lamboley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state

(2013) Chikashi Toyoshima et al.   NATURE

The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm

(2013) Anne-Marie L. Winther et al.   NATURE

EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

(2013) Haruya Ohno et al.   NATURE

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

Development of the Mouse Dermal Adipose Layer Occurs Independently of Subcutaneous Adipose Tissue and Is Marked by Restricted Early Expression of FABP4

(2013) Kamila Wojciechowicz et al.   PLoS One

Maximal Aerobic and Anaerobic Power Generation in Large Crocodiles versus Mammals: Implications for Dinosaur Gigantothermy

(2013) Roger S. Seymour   PLoS One

Co-Expression of SERCA Isoforms, Phospholamban and Sarcolipin in Human Skeletal Muscle Fibers

(2013) Val A. Fajardo et al.   PLoS One

The radiation of cynodonts and the ground plan of mammalian morphological diversity

(2013) M. Ruta et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Brown fat in a protoendothermic mammal fuels eutherian evolution

(2013) Rebecca Oelkrug et al.   Nature Communications

Ca2+/H+ exchange, lumenal Ca2+ release and Ca2+/ATP coupling ratios in the sarcoplasmic reticulum ATPase

(2013) Giuseppe Inesi et al.   Journal of Cell Communication and Signaling

Uncoupling of sarcoplasmic reticulum Ca2+-ATPase by N-arachidonoyl dopamine. Members of the endocannabinoid family as thermogenic drugs

(2012) YA Mahmmoud et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PTEN Loss in the Myf5 Lineage Redistributes Body Fat and Reveals Subsets of White Adipocytes that Arise from Myf5 Precursors

(2012) Joan Sanchez-Gurmaches et al.   Cell Metabolism

Specific effects of endurance and sprint training on protein expression of calsequestrin and SERCA in mouse skeletal muscle

(2012) Sanni Kinnunen et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Seasonal bone growth and physiology in endotherms shed light on dinosaur physiology

(2012) Meike Köhler et al.   NATURE

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

Wnt signaling in myogenesis

(2012) Julia von Maltzahn et al.   TRENDS IN CELL BIOLOGY

Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice

(2011) A. Russell Tupling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Thermogenesis, muscle hyperplasia, and the origin of birds

(2011) Stuart A. Newman   BIOESSAYS

Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/PiTransporter) Reduces Physical Endurance and Metabolic Efficiency in Mice

(2011) Rea P. Anunciado-Koza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiber Types in Mammalian Skeletal Muscles

(2011) Stefano Schiaffino et al.   PHYSIOLOGICAL REVIEWS

Developmental Origins of the Adipocyte Lineage: New Insights from Genetics and Genomics Studies

(2011) Nathalie Billon et al.   Stem Cell Reviews and Reports

Using new tools to solve an old problem: the evolution of endothermy in vertebrates

(2011) Roberto F. Nespolo et al.   TRENDS IN ECOLOGY & EVOLUTION

Distribution Pattern of Muscle Fiber Types in the Perivertebral Musculature of Two Different Sized Species of Mice

(2010) Bettina Hesse et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Distribution and Development of Brown Adipocytes in the Murine and Human Adipose Organ

(2010) Andrea Frontini et al.   Cell Metabolism

Brown adipose tissue in humans

(2010) Kirsi A Virtanen et al.   CURRENT OPINION IN LIPIDOLOGY

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Metabolic rates, genetic constraints, and the evolution of endothermy

(2010) J. P. HAYES   JOURNAL OF EVOLUTIONARY BIOLOGY

Cold-acclimation-induced non-shivering thermogenesis in birds is associated with upregulation of avian UCP but not with innate uncoupling or altered ATP efficiency

(2010) L. Teulier et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis

(2009) David A Hughes et al.   BMC EVOLUTIONARY BIOLOGY

Proteome Differences between Brown and White Fat Mitochondria Reveal Specialized Metabolic Functions

(2009) Francesca Forner et al.   Cell Metabolism

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Thermodynamic constraints on neural dimensions, firing rates, brain temperature and size

(2009) Jan Karbowski   JOURNAL OF COMPUTATIONAL NEUROSCIENCE

Evidence for cranial endothermy in the opah (Lampris guttatus)

(2009) R. M. Runcie et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Endothermy in birds: underlying molecular mechanisms

(2009) I. Walter et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Biomechanics of Running Indicates Endothermy in Bipedal Dinosaurs

(2009) Herman Pontzer et al.   PLoS One

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mass of Slow-Type Skeletal Muscles and Depressed Myostatin Gene Expression in Cold-Tolerant Chicks

(2009) Daichi Ijiri et al.   ZOOLOGICAL SCIENCE

The brown adipocyte differentiation pathway in birds: An evolutionary road not taken

(2008) Nadejda V Mezentseva et al.   BMC BIOLOGY

Brown Fat and Skeletal Muscle: Unlikely Cousins?

(2008) Stephen R. Farmer   CELL

Ontogeny and phylogeny of endothermy and torpor in mammals and birds

(2008) Fritz Geiser   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis

(2008) N. Gensch et al.   DEVELOPMENT

Cold Tolerance in Hypothyroid Rabbits: Role of Skeletal Muscle Mitochondria and Sarcoplasmic Reticulum Ca2+ATPase Isoform 1 Heat Production

(2008) Ana Paula Arruda et al.   ENDOCRINOLOGY

Is the Ca2+-ATPase from sarcoplasmic reticulum also a heat pump?

(2008) Signe Kjelstrup et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Nonshivering thermogenesis protects against defective calcium handling in muscle

(2008) Jan Aydin et al.   FASEB JOURNAL

Capsaicin Stimulates Uncoupled ATP Hydrolysis by the Sarcoplasmic Reticulum Calcium Pump

(2008) Yasser A. Mahmmoud   JOURNAL OF BIOLOGICAL CHEMISTRY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals

(2007) Shigeru Saito et al.   GENE

Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis

(2007) M. Jastroch et al.   PHYSIOLOGICAL GENOMICS