The Role of HIF1α-PFKFB3 Pathway in Diabetic Retinopathy

PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function

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Restoring vision to the blind

(2020) John E. Dowling   SCIENCE

Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy

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Basic and Therapeutic Aspects of Angiogenesis Updated

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STEAP4 Inhibits HIF-1α/PKM2 Signaling and Reduces High Glucose-Induced Apoptosis of Retinal Vascular Endothelial Cells

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Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy

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MicroRNA-135b-5p promotes endothelial cell proliferation and angiogenesis in diabetic retinopathy mice by inhibiting Von Hipp-el-Lindau and elevating hypoxia inducible factor α expression

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11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2021

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HIF-1α protects against oxidative stress by directly targeting mitochondria

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The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific

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Loss of MPC1 reprograms retinal metabolism to impair visual function

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Pharmacological HIF inhibition prevents retinal neovascularization with improved visual function in a murine oxygen-induced retinopathy model

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PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

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IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

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Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes

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PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production

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HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model

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Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

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IL-27 regulates HIF-1α-mediated VEGFA response in macrophages of diabetic retinopathy patients and healthy individuals

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Role of Inflammation in Diabetic Retinopathy

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Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells

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Identification of a functional antioxidant response element at the HIF1A locus

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Notch signaling suppresses glucose metabolism in mesenchymal progenitors to restrict osteoblast differentiation

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NAP counteracts hyperglycemia/hypoxia induced retinal pigment epithelial barrier breakdown through modulation of HIFs and VEGF expression

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Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy

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Lutein downregulates retinal vascular endothelial growth factor possibly via hypoxia inducible factor 1 alpha and X-box binding protein 1 expression in streptozotocin induced diabetic rats

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Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

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HIF-1α triggers long-lasting glutamate excitotoxicity via system xc − in cerebral ischaemia-reperfusion

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Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

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Diabetic retinopathy

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Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

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PFKFB3-mediated glycolysis is involved in reactive astrocyte proliferation after oxygen-glucose deprivation/reperfusion and is regulated by Cdh1

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Angiogenesis and Eye Disease

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Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

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Ocular Anti-VEGF Therapy for Diabetic Retinopathy: Overview of Clinical Efficacy and Evolving Applications

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Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

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The Morphological Features and Mitochondrial Oxidative Stress Mechanism of the Retinal Neurons Apoptosis in Early Diabetic Rats

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Role of Endothelial Cell Metabolism in Vessel Sprouting

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Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

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PFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in Cancer

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Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T Polymorphisms and Susceptibility to Type 2 Diabetes Mellitus: Case-Control Study and Meta-Analysis

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Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

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Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

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Mitochondrial Dysfunction in Retinal Diseases

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Diabetic Retinopathy

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Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Müller cells

(2011) M. Lin et al.   DIABETOLOGIA

LOH on 10p14-p15 targets the PFKFB3 gene locus in human glioblastomas

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Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)- -TrCP, sequentially regulate glycolysis during the cell cycle

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Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

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Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

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Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

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HIF at a glance

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Müller cell-derived VEGF is a significant contributor to retinal neovascularization

(2009) Yanyan Bai et al.   JOURNAL OF PATHOLOGY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

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Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina

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Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial--Revisited

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Intravitreous anti-VEGF for diabetic retinopathy: hopes and fears for a new therapeutic strategy

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The Angio-Fibrotic Switch of VEGF and CTGF in Proliferative Diabetic Retinopathy

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