Article
Medicine, Research & Experimental
Xiwei Fan, Reuben S. E. Young, Antonia Rujia Sun, Brett R. Hamilton, Udhaya Nedunchezhiyan, Ross Crawford, Stephen J. Blanksby, Indira Prasadam
Summary: This study used mass spectrometry imaging to visualize the distribution of lipase enzymes in bone and cartilage tissue sections and correlated them with immunohistochemistry staining results. The results showed that OA patients exhibited increased expression of PLA(2)G(2)A at the superficial and deep cartilage zones, indicating that tissue-specific inhibition of PLA(2)G(2)A may be a potential therapeutic target for OA.
Article
Environmental Sciences
Yanyan Chen, Lilong Jiang, Rong Zhang, Zhangsheng Shi, Chengyi Xie, Yanjun Hong, Jianing Wang, Zongwei Cai
Summary: This study used AP-MALDI MSI to reveal the spatial distributions of PFOS in mouse kidneys and its adverse effects on lipid metabolism. PFOS was found to accumulate mainly in the renal pelvis and outer cortex regions, causing damage to the kidneys. Significant down-regulation of certain lipids and up-regulation of others were observed in different regions of the kidneys between control and PFOS-exposed mice.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Medicinal
Ariful Islam, Takumi Sakamoto, Qing Zhai, Md Muedur Rahman, Md Al Mamun, Yutaka Takahashi, Tomoaki Kahyo, Mitsutoshi Setou
Summary: This study applied three different tools of mass spectrometry imaging (MSI) to visualize drugs and their metabolites in mice. Among the three MSI tools, iMScope QT demonstrated better detection capability and higher speed for rapid mapping of targeted drugs. The study found that imipramine and its metabolites predominantly accumulated in the renal cortex of mice, while chloroquine and its metabolites accumulated highly in the renal pelvis and renal medulla. In addition, different accumulation patterns were observed in various regions of the mouse brain. These findings contribute to the understanding of the clinical properties, efficacy, and potential side effects of these drugs, and demonstrate the potential of iMScope QT for rapid mapping of small drugs and their metabolites in biological samples.
Article
Biochemistry & Molecular Biology
Manoj Yadav, Prem Prashant Chaudhary, Brandon N. D'Souza, Jacquelyn Spathies, Ian A. Myles
Summary: The study found that different fixation methods significantly impact the analysis of metabolite content and distribution. Samples fixed in formalin and paraffin and fresh frozen samples showed substantial differences in the sharing of metabolites, but both methods allowed for downstream fluorescent staining.
Article
Food Science & Technology
Mudita Vats, Berta Cillero-Pastor, Bryn Flinders, Eva Cuypers, Ron M. A. Heeren
Summary: This study utilized MALDI-MSI to determine the spatial distribution of flavor compounds in edible button mushrooms and optimized the sample preparation protocol and investigated the effect of heat on the distribution.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Medicine, Legal
Marie Gorka, Aurelien Thomas, Andy Becue
Summary: Scientific developments have focused on using mass spectrometry to analyze fingermarks, with a dedicated quality control test strip developed to assess reproducibility and conduct inter-laboratory comparisons. The test strip combines visual templates with artificial fingerprint secretions and has shown potential for evaluating fingermark detection techniques and monitoring mass-spectrometry-based techniques over time.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Ana Claudia Hertel Pereira, Ana Carolina Auer, Lauro Biedel, Camila Medeiros de Almeida, Wanderson Romao, Denise Coutinho Endringer
Summary: The study investigates the potential use of Gliricidia sepium as a raw material for natural cosmetics. It examines the chemical composition, antioxidant potential, antimicrobial action, and toxicity of the plant. The study also explores the use of MALDI MS and MALDI MSI techniques to analyze the spatial distribution of phytochemicals on the leaf surface. The results show that G. sepium leaves contain polyphenols and tannins, with a higher flavonoid content in the methanolic extract. Several compounds with potential cosmetic applications, such as kaempferol, isorhamnetin, and fatty acids, are identified on the leaf surface. The extracts exhibit antioxidant and antimicrobial properties without cytotoxicity.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Engineering, Environmental
Xin Diao, Chengyi Xie, Guangshan Xie, Yuanyuan Song, Yanshan Liang, Ruijin Li, Chuan Dong, Lin Zhu, Jianing Wang, Zongwei Cai
Summary: This study utilized advanced techniques to investigate the spatial distribution of lipids in rat brains after exposure to high levels of PM2.5. The findings suggest a possible association between PM2.5 exposure and neurological damage, potentially mediated by reductions in sulfatides and subsequent neuroinflammation in the corpus callosum region.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Elvira Sgobba, Yohann Daguerre, Marco Giampa
Summary: Classic metabolomic methods have limitations in spatial localization within fine structures, while MALDI MSI provides high spatial resolution for analyzing the local complexity of biological samples. This technology has been widely used in medical sciences and is now expanding to various research areas, demonstrating its strength in characterizing spatial distributions of metabolites, lipids, and peptides in relation to biological questions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Yan-Xia Zhang, Yi-Da Zhang, Yan-Ping Shi
Summary: Exploring the spatial distribution alterations of metabolites during lentil germination is crucial for understanding its nutritional value, physiological function, and metabolic pathway. This study established an effective MALDI-MSI method to visualize the changes in spatial localization of 53 metabolites in lentils during germination. The results showed specific distribution patterns of different metabolites, with certain lipids mainly located in the cotyledons and others spreading throughout the lentil tissue during early germination. Heat map analysis demonstrated the correlation between lipid content changes and germination time, supporting the potential use of germinated lentils as nutraceutical or functional food.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agricultural Engineering
Jiao Wu, Chuang Cui, Hongwei Zhao, Guangzhen Zhou, Liang Qin, Xinyu Li, Lulu Chen, Xiaodong Wang, Yinglang Wan
Summary: Arecoline, a prevalent alkaloid in areca fruits, is considered the fourth most consumed addictive drug globally. This study utilized multiple techniques to analyze the alkaloids in areca fruits and provided information on their distribution in different tissues, contributing to the optimal utilization of areca fruits.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Chemistry, Physical
Paulina Kret, Anna Bodzon-Kulakowska, Anna Drabik, Joanna Ner-Kluza, Piotr Suder, Marek Smoluch
Summary: The science related to biomaterials and tissue engineering is expanding, with a focus on surface modifications and interactions with surrounding tissues. Mass Spectrometry Imaging (MSI) techniques can measure molecular composition from biomaterials and adjacent tissue simultaneously, without the need for antibodies or dyes that may affect the results.
Article
Environmental Sciences
Yu Bian, Mu-Yi He, Yun Ling, Xiu-Juan Wang, Feng Zhang, Xue-Song Feng, Yuan Zhang, Shi-Ge Xing, Jie Li, Xin Qiu, Yu-Rui Li
Summary: The study introduced a new strategy to investigate the distribution of PFOA in tissues and estimate the exposure stages, using MALDI-MSI method to monitor the spatio-temporal distribution of PFOA in zebrafish tissues. By analyzing the law of change obtained from high spatial resolution MSI data, two different enrichment trends in ten tissues were summarized by curve fitting, defining a new exposure curve to evaluate the exposure stages. With this model, three levels (mild, moderate, and deep pollution stage) of PFOA pollution in zebrafish can be simply evaluated.
ENVIRONMENTAL POLLUTION
(2022)
Article
Food Science & Technology
Maria Garcia-Martin, Lynn Huntsinger, Maria Jose Ibarrola-Rivas, Marianne Penker, Ugo D'Ambrosio, Thymios Dimopoulos, Maria E. Fernandez-Gimenez, Thanasis Kizos, Jose Munoz-Rojas, Osamu Saito, Karl S. Zimmerer, David J. Abson, Jianguo Liu, Cristina Quintas-Soriano, Irene Holm Sorensen, Peter H. Verburg, Tobias Plieninger
Summary: This article explores the multiple functions of seven landscape products worldwide, emphasizing that landscape products can improve food systems by promoting place-sensitive sustainability strategies and standards, thus addressing conflicts related to food production, social justice, and the environment.
Article
Biochemistry & Molecular Biology
Matthias Buerger, Oliver Klein, Sebastian Kapahnke, Verena Mueller, Jan Paul Frese, Safwan Omran, Andreas Greiner, Manuela Sommerfeld, Elena Kaschina, Anett Jannasch, Claudia Dittfeld, Adrian Mahlmann, Irene Hinterseher
Summary: The study utilized MALDI-MSI to identify peptide signatures in patients with TAA, AAA, and EVAR, revealing impaired contractility in vascular smooth muscle cells, lack of energy production due to mitochondrial dysfunction, and continuous degradation of extracellular matrix components leading to aortic wall destabilization.
Article
Multidisciplinary Sciences
Yuki Takemoto, Chihiro Kishi, Yuki Sugiura, Yuri Yoshioka, Shinichi Matsumura, Tatsuya Moriyama, Nobuhiro Zaima
Summary: The study found that inhaled volatile BCP is widely distributed in murine tissues and affects the dynamics of metabolites in the liver.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Eri Izumi, Shota Hidaka, Ayako Hiroi, Serina Kinugasa, Erika Yano, Nobuhiro Zaima, Tatsuya Moriyama
Summary: Recent studies have shown that food allergens can enter the skin and predispose individuals to food allergies by stimulating the production of IgE antibodies. A study on cherry allergens found that a thaumatin-like protein (Pru av 2) triggered percutaneous sensitization in mice, identifying it as a major cherry allergen affecting humans. This research provides new insights into cherry allergies and their mechanisms of sensitization.
Article
Biology
Hirona Kugo, Wanida Sukketsiri, Hiroki Tanaka, Rena Fujishima, Tatsuya Moriyama, Nobuhiro Zaima
Summary: Abdominal aortic aneurysm (AAA) involves gradual dilation of the abdominal aorta and has a high mortality due to rupture, with hypoperfusion being a key factor. Time-dependent analysis is crucial to understanding the pathological cascade following hypoperfusion, which may directly affect AAA development. Findings suggest that hypoperfusion-induced hypoxia plays a significant role in the activities of contractile smooth muscle cells, contributing to the progression of AAA.
Article
Biochemistry & Molecular Biology
Ayana Ieda, Maki Wada, Yuuki Moriyasu, Yuuko Okuno, Nobuhiro Zaima, Tatsuya Moriyama
Summary: The study found that ellagic acid (EA) can inhibit the secretion of apolipoprotein B from hepatic cells while enhancing the secretion of apolipoprotein A-1, benefiting lipoprotein metabolism and the prevention of lifestyle-related diseases. Further exploration of the detailed mechanisms behind these effects is needed, but EA shows promise as an antihyperlipidemic compound derived from food.
Article
Food Science & Technology
Yuki Takemoto, Tomoko Sumi, Chihiro Kishi, Shohei Makino, Yuri Yoshioka, Shinichi Matsumura, Tatsuya Moriyama, Nobuhiro Zaima
Summary: Turmerones, the main bioactive compounds in turmeric, are used as herbal medicines in Asia due to their strong flavor and volatility. This study found that inhaled volatile turmerones can be incorporated into the animal body with varying concentrations in different organs, indicating their distribution throughout the body.
Article
Medicine, General & Internal
Takanori Enomoto, Reina Sekiya, Hiroshi Sugimoto, Tomomi Terashita, Junya Yoshioka, Tatsuya Nagano, Yoshihiro Nishimura, Erika Yano, Tatsuya Moriyama, Kyosuke Nakata
Summary: This is a case of a 73-year-old woman who was admitted to the hospital for cough and dyspnea. High-resolution computed tomography revealed patchy ground-glass attenuation in the upper lung field. The patient was diagnosed with hypersensitivity pneumonitis related to exposure to a gray parrot based on immunoblotting analysis showing IgG-binding fractions to the gray parrot's feathers.
Letter
Dermatology
Shunsuke Miura, Tatsuya Moriyama, Junko Yoshimura, Kaichi Umehara, Haruko Hino, Takahiko Tsunoda, Shinji Kagami
JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eri Izumi, Nana Tanahashi, Serina Kinugasa, Shota Hidaka, Nobuhiro Zaima, Tatsuya Moriyama
Summary: The study revealed that tannic acid (TA) can prevent transdermal sensitization to ovalbumin (OVA) by its anti-inflammatory and astringent effects on the skin, as well as its binding ability with the protein. These findings suggest that TA may be applied in cosmetics and lotions to suppress transdermal sensitization to allergens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Hirona Kugo, Hiroki Tanaka, Tatsuya Moriyama, Nobuhiro Zaima
JOURNAL OF LIPID RESEARCH
(2022)
Article
Multidisciplinary Sciences
Atsushi Kurata, Shogo Kiyohara, Tomoya Imai, Shino Yamasaki-Yashiki, Nobuhiro Zaima, Tatsuya Moriyama, Noriaki Kishimoto, Koichi Uegaki
Summary: We investigated the characteristics and functionalities of Lactiplantibacillus plantarum extracellular vesicles (EVs) towards host immune cells and found that these EVs activate both innate and acquired immune responses. Additionally, we discovered a significant amount of EVs in the rat gastrointestinal tract, suggesting their role as modulators of intestinal immunity.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Chihiro Kishi, Mayo Higashihara, Yuki Takemoto, Moeka Kamei, Yuri Yoshioka, Shinichi Matsumura, Kazuya Yamada, Takanori Kobayashi, Yoshiharu Matahira, Tatsuya Moriyama, Nobuhiro Zaima
Summary: The study demonstrates that inhalation of volatile BCP can prevent nicotine-induced degeneration of the aorta, and this effect is mediated through the CB2 receptor.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hirona Kugo, Hirofumi Enomoto, Kenichi Yanagimoto, Hiroki Tanaka, Tatsuya Moriyama, Nobuhiro Zaima
Summary: This study visualized the distribution of EPA-containing phosphatidylcholine (EPA-PC) in the AAA wall and found that EPA is associated with the attenuation of MSC dysfunctions, which result in the suppression of AAA development.
Article
Chemistry, Applied
Kento Miyamoto, Sakura Hasuike, Hirona Kugo, Wanida Sukketsiri, Tatsuya Moriyama, Nobuhiro Zaima
Summary: Women are more resistant to vascular diseases, but this resistance decreases after menopause. Isoflavones from soybeans have been found to inhibit aortic wall degeneration in postmenopausal women, reducing the destruction of elastic fibers and decreasing the positive areas of matrix metalloproteinases.
JOURNAL OF OLEO SCIENCE
(2022)
Article
Endocrinology & Metabolism
Hirona Kugo, Wanida Sukketsiri, Kazuko Iwamoto, Satoki Suihara, Tatsuya Moriyama, Nobuhiro Zaima
Summary: This study investigated the changes in inflammation-related factors in adipocytes at low glucose and serum levels. The results indicated that low glucose and serum levels enhanced the production of AAA-related factors, and increased the levels of inflammatory factors through the activation of multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Rena Fujishima, Hirona Kugo, Kenichi Yanagimoto, Hirofumi Enomoto, Tatsuya Moriyama, Nobuhiro Zaima
Summary: The research suggests that eicosapentaenoic acid (EPA) may suppress the development of abdominal aortic aneurysm (AAA) by enhancing the anti-inflammatory properties of M2 macrophages.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
